R65.1 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Version 2023
No Valid Principal Dx
ICD-10:R65.1
Short Description:SIRS of non-infectious origin
Long Description:Systemic inflammatory response syndrome (SIRS) of non-infectious origin
Status: Not Valid for Submission
Version:ICD-10-CM 2023
Code Classification:
  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99)
    • General symptoms and signs (R50-R69)
      • Symp and signs specifically assoc w sys inflam and infct (R65)

R65.1 is a non-specific and non-billable ICD-10 code code, consider using a code with a higher level of specificity for a diagnosis of systemic inflammatory response syndrome (sirs) of non-infectious origin. The code is not specific and is NOT valid for the year 2023 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.

Specific Coding for SIRS of non-infectious origin

Non-specific codes like R65.1 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for sirs of non-infectious origin:

  • BILLABLE CODE - Use R65.10 for Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
  • BILLABLE CODE - Use R65.11 for Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to this diagnosis code:


Code First

Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

Code History