2027 ICD-10-CM Diagnosis Code L53.0Toxic erythema

ICD-10-CM Codes›L00–L99›L49-L54›L53

ICD-10-CM L53.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

L53.0 is a billable ICD-10-CM diagnosis code for toxic erythema. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 595 through 596, 791, 793. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 27 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other specified inflammatory condition of skin.

Code Identity

ICD-10-CM Code
L53.0
Billable Status
Yes — Valid for Submission
Code Describes
Toxic erythema
Short Description
Toxic erythema
Same as the full description in the CMS dataset.
Parent Code
L53
Other erythematous conditions

Code Classification

ChapterL00–L99Diseases of the skin and subcutaneous tissue
SectionL49-L54Urticaria and erythema
CategoryL53Other erythematous conditions
This CodeL53.0Toxic erythema

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acral erythema due to cytotoxic therapy
  • Annular erythema
  • Annular erythema caused by drug
  • Contact dermatitis caused by hydrocarbon
  • Contact dermatitis caused by ketone
  • Danthron erythema
  • Dermatosis due to cytotoxic therapy
  • Diffuse inflammatory erythema
  • Drug exanthem
  • Exanthematous disorder
  • Palmar erythema
  • Toxic erythema caused by drug
  • Toxic urticated erythema
  • Toxic urticated erythema caused by drug

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to L53.0: its own notes plus those printed at L53, block L49-L54, and Chapter 12. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On L53.0 itself
  • neonatal erythema toxicum (P83.1)
From L53 Other erythematous conditions applies to 6 codes
  • erythema ab igne (L59.0)
  • erythema due to external agents in contact with skin (L23-L25)
  • erythema intertrigo (L30.4)
From Block L49-L54 Urticaria and erythema applies to 33 codes

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 12 (L00-L99) Diseases of the skin and subcutaneous tissue applies to 1,001 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • lipomelanotic reticulosis (I89.8)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
  • systemic connective tissue disorders (M30-M36)
  • viral warts (B07.-)

Code First

The underlying condition named in the note is sequenced before this code.

  • poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient No · outpatient No
CCSR SKN002
Other specified inflammatory condition of skin
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Skin Conditions

Your skin is your body's largest organ. It covers the entire outside of your body. There are many ways that your skin protects your body and helps keep you healthy. For example, it:

The full article covers:

  • What does your skin do?
  • What problems and conditions can affect your skin?
  • How can I keep my skin healthy?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert L53.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
695.0 Toxic erythema
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About L53.0Overview

What is the ICD-10 code for toxic erythema?

The ICD-10-CM code for toxic erythema is L53.0 (sometimes written as L530). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is L53.0 (Other erythematous conditions) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report toxic erythema on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does L53.0 group to?

When toxic erythema is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 596, 595, with relative weights from 1.1067 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.

Is L53.0 a CC or MCC?

CMS lists L53.0 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 27 closely related codes in its exclusion list.

Can L53.0 be reported with P83.1?

Not as a rule. The Excludes1 note on L53.0 lists "neonatal erythema toxicum (P83.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).