2026 ICD-10-CM Diagnosis Code L27.0Generalized skin eruption due to drugs and medicaments taken internally

ICD-10-CM Codes›L00–L99›L20-L30›L27

ICD-10-CM L27.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

L27.0 is a billable ICD-10-CM diagnosis code for generalized skin eruption due to drugs and medicaments taken internally. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 606 through 607. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Allergic reactions and Other specified inflammatory condition of skin.

Code Identity

ICD-10-CM Code
L27.0
Billable Status
Yes — Valid for Submission
Code Describes
Generalized skin eruption due to drugs and medicaments taken internally
Short Description
Gen skin eruption due to drugs and meds taken internally
Parent Code
L27
Dermatitis due to substances taken internally

Code Classification

ChapterL00–L99Diseases of the skin and subcutaneous tissue
SectionL20-L30Dermatitis and eczema
CategoryL27Dermatitis due to substances taken internally
This CodeL27.0Generalized skin eruption due to drugs and medicaments taken internally

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adverse reaction to ampicillin and/or cloxacillin
  • Adverse reaction to ampicillin and/or floxacillin
  • Ampicillin adverse reaction
  • Broad spectrum penicillins adverse reaction
  • Drug exanthem
  • Drug-induced ichthyosiform reaction
  • Epstein-Barr virus infectious mononucleosis
  • Eruption caused by drug
  • Eruption of skin caused by antiretroviral drug
  • Exanthematous disorder
  • Generalized rash
  • Generalized skin eruption caused by drug and medicament
  • Halogen eruption
  • Infectious mononucleosis ampicillin reaction
  • Infectious mononucleosis exanthem
  • Injection site eruption
  • Maculopapular drug eruption
  • Maculopapular eruption
  • Maculopapular rash caused by fluoroquinolone
  • Pseudolymphomatous eruption caused by drug
  • Retinoid dermatitis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dermatitis(eczematous)
      • due to
        • drugs and medicaments (generalized) (internal use)
    • Dermatitis(eczematous)
      • due to
        • vaccine or vaccination
    • Eruption
      • drug (generalized) (taken internally)
    • Eruption
      • skin (nonspecific)
        • due to inoculation/vaccination (generalized)
    • Rash(toxic)
      • drug (internal use)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ031
Allergic reactions
Default principal diagnosis: inpatient No · outpatient No
CCSR SKN002
Other specified inflammatory condition of skin
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert L27.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
693.0 Drug dermatitis NOS
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About L27.0Overview

Is L27.0 (Dermatitis due to substances taken internally) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report generalized skin eruption due to drugs and medicaments taken internally on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does L27.0 group to?

When generalized skin eruption due to drugs and medicaments taken internally is the principal diagnosis on an inpatient stay, it groups to MS-DRG 606, 607, with relative weights from 0.9064 to 1.5132 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of L27.0?

Under the General Equivalence Mappings, generalized skin eruption due to drugs and medicaments taken internally converts to ICD-9-CM 693.0 (drug dermatitis NOS). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.