2027 ICD-10-CM Diagnosis Code L27.0Generalized skin eruption due to drugs and medicaments taken internally
ICD-10-CM Codes›L00–L99›L20-L30›L27
- Billable — Valid for Submission
- Not Chronic
L27.0 is a billable ICD-10-CM diagnosis code for generalized skin eruption due to drugs and medicaments taken internally. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 606 through 607, 791, 793. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Allergic reactions and Other specified inflammatory condition of skin.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to ampicillin and/or cloxacillin
- Adverse reaction to ampicillin and/or floxacillin
- Ampicillin adverse reaction
- Broad spectrum penicillins adverse reaction
- Drug exanthem
- Drug-induced ichthyosiform reaction
- Epstein-Barr virus infectious mononucleosis
- Eruption caused by drug
- Eruption of skin caused by antiretroviral drug
- Exanthematous disorder
- Fixed drug eruption
- Fixed drug reaction
- Generalized bullous fixed drug eruption
- Generalized rash
- Generalized skin eruption caused by drug and medicament
- Halogen eruption
- Infectious mononucleosis ampicillin reaction
- Infectious mononucleosis exanthem
- Injection site eruption
- Maculopapular drug eruption
- Maculopapular eruption
- Maculopapular rash caused by fluoroquinolone
- Pseudolymphomatous eruption caused by drug
- Retinoid dermatitis
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to L27.0: its own notes plus those printed at L27, block L20-L30, and Chapter 12. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- lipomelanotic reticulosis (I89.8)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- systemic connective tissue disorders (M30-M36)
- viral warts (B07.-)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Notes
General instructions on how these codes are used.
- In this block the terms dermatitis and eczema are used synonymously and interchangeably.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name L27.0, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming L27.0: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 7
These codes carry an Excludes2 note naming L27.0: its condition is not part of those codes, and both may be reported when the patient has both.
- L23.3 Allergic contact dermatitis due to drugs in contact with skin
- L25.1 Unspecified contact dermatitis due to drugs in contact with skin
- T81 Complications of procedures, not elsewhere classified
- T88 Other complications of surgical and medical care, not elsewhere classified
- L23 Allergic contact dermatitisdermatitis due to substances taken internally (L27.-) names L27.-, which includes this code
- L24 Irritant contact dermatitisdermatitis due to substances taken internally (L27.-) names L27.-, which includes this code
- L25 Unspecified contact dermatitisdermatitis due to ingested substances (L27.-) names L27.-, which includes this code
Code First 1
These codes say to code first a condition named in the note, and L27.0 is one of the conditions named.
- Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substancesdermatitis due to substances taken internally (L27.-) names L27.-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
due to inoculation/vaccination (generalized) See Also: Dermatitis, due to, vaccine; L27.0
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert L27.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About L27.0Overview
Is L27.0 (Dermatitis due to substances taken internally) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report generalized skin eruption due to drugs and medicaments taken internally on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does L27.0 group to?
When generalized skin eruption due to drugs and medicaments taken internally is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 607, 606, with relative weights from 0.8772 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.
Can L27.0 be reported with T78.40?
Not as a rule. The Excludes1 note at L27, which applies to L27.0, lists "allergy NOS (T78.40)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does L27.0 need an additional code?
When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after L27.0.
What is the ICD-9 equivalent of L27.0?
Under the General Equivalence Mappings, generalized skin eruption due to drugs and medicaments taken internally converts to ICD-9-CM 693.0 (drug dermatitis NOS). The mapping is approximate, so confirm the match fits the documentation.
