2026 ICD-10-CM Diagnosis Code K72.01Acute and subacute hepatic failure with coma

ICD-10-CM Codes›K00–K95›K70-K77›K72

ICD-10-CM K72.01
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

K72.01 is a billable ICD-10-CM diagnosis code for acute and subacute hepatic failure with coma. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 441 through 443. Coders also document this condition as hepatic coma due to acute hepatic failure. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coma; stupor; and brain damage and Hepatic failure.

Code Identity

ICD-10-CM Code
K72.01
Billable Status
Yes — Valid for Submission
Code Describes
Acute and subacute hepatic failure with coma
Short Description
Acute and subacute hepatic failure with coma
Same as the full description in the CMS dataset.
Parent Code
K72.0
Acute and subacute hepatic failure

Code Classification

ChapterK00–K95Diseases of the digestive system
SectionK70-K77Diseases of liver
CategoryK72Hepatic failure, not elsewhere classified
This CodeK72.01Acute and subacute hepatic failure with coma

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hepatic coma due to acute hepatic failure
  • Hepatic coma due to subacute liver failure

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Atrophy, atrophic(of)
      • liver (yellow)
        • acute, subacute
          • with coma
    • Degeneration, degenerative
      • liver (diffuse) NEC
        • parenchymatous, acute or subacute
          • with coma
    • Failure, failed
      • hepatic
        • acute or subacute
          • with coma
    • Hepatitis
      • acute
        • with coma

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS013
Coma; stupor; and brain damage
Default principal diagnosis: inpatient No · outpatient No
CCSR DIG018
Hepatic failure
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Coma

A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert K72.01 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
570 Acute necrosis of liver
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
572.2 Hepatic encephalopathy
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About K72.01Overview

Is K72.01 (Acute and subacute hepatic failure) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acute and subacute hepatic failure with coma on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does K72.01 group to?

When acute and subacute hepatic failure with coma is the principal diagnosis on an inpatient stay, it groups to MS-DRG 441, 442, 443, with relative weights from 0.6997 to 1.7947 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of K72.01?

Under the General Equivalence Mappings, acute and subacute hepatic failure with coma converts to ICD-9-CM 570 (acute necrosis of liver) and 572.2 (hepatic encephalopathy). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.