2027 ICD-10-CM Diagnosis Code I25.10Atherosclerotic heart disease of native coronary artery without angina pectoris

ICD-10-CM Codes›I00–I99›I20-I25›I25

ICD-10-CM I25.10
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

I25.10 is a billable ICD-10-CM diagnosis code for atherosclerotic heart disease of native coronary artery without angina pectoris. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 302 through 303. The code is restricted by the Medicare Code Editor to adult patients (age 15 through 124). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coronary atherosclerosis and other heart disease.

I25.10 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 188 for payment year 2027.

This medical diagnosis code is frequently used in Cardiology medical specialties to designate conditions such selected atherosclerosis, ischemia, and infarction.

Code Identity

ICD-10-CM Code
I25.10
Billable Status
Yes — Valid for Submission
Code Describes
Atherosclerotic heart disease of native coronary artery without angina pectoris
Short Description
Athscl heart disease of native coronary artery w/o ang pctrs
Parent Code
I25.1
Atherosclerotic heart disease of native coronary artery

Code Classification

ChapterI00–I99Diseases of the circulatory system
SectionI20-I25Ischemic heart diseases
CategoryI25Chronic ischemic heart disease
This CodeI25.10Atherosclerotic heart disease of native coronary artery without angina pectoris

Code EditsBilling

Medicare Code Editor checks that affect claim validity for I25.10.

Adult diagnoses
The Medicare Code Editor detects inconsistencies in adult cases by checking a patient's age and any diagnosis on the patient's record. The adult code edits apply to patients age range is 15–124 years inclusive (e.g., senile delirium, mature cataract).

Medicare Risk Adjustment (HCC)Billing

I25.10 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
no payment category in the model that pays 100% of MA risk scores
Prior Model (CMS-HCC V24)
Not mapped under V24
this diagnosis newly risk-adjusts under the V28 model
Part D (RxHCC)
RxHCC 188 — Coronary Artery Disease
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Asymptomatic coronary heart disease
  • Atheroma of artery
  • Atherosclerosis of anterior descending branch of left coronary artery
  • Atherosclerosis of circumflex branch of left coronary artery
  • Atherosclerosis of coronary artery without angina pectoris
  • Atherosclerosis of distal portion of right coronary artery
  • Atherosclerosis of left coronary artery
  • Atherosclerosis of left coronary artery main stem
  • Atherosclerosis of mid portion of anterior descending branch of left coronary artery
  • Atherosclerosis of mid portion of circumflex branch of left coronary artery
  • Atherosclerosis of mid portion of right coronary artery
  • Atherosclerosis of proximal portion of anterior descending branch of left coronary artery
  • Atherosclerosis of proximal portion of circumflex branch of left coronary artery
  • Atherosclerosis of proximal portion of right coronary artery
  • Atherosclerosis of right coronary artery
  • Calcific coronary arteriosclerosis
  • Coronary arteriosclerosis
  • Coronary arteriosclerosis caused by ionizing radiation
  • Coronary arteriosclerosis in patient with history of previous myocardial infarction
  • Coronary artery atheroma
  • Coronary artery disease due to type 1 diabetes mellitus
  • Coronary artery disease due to type 2 diabetes mellitus
  • Coronary atherosclerosis
  • Coronary ostium stenosis
  • Coronary stricture
  • Disorder of artery caused by ionizing radiation
  • Double coronary vessel disease
  • Heart disease caused by ionizing radiation
  • Heart failure with normal ejection fraction
  • Heart failure with reduced ejection fraction
  • Heart failure with reduced ejection fraction due to coronary artery disease
  • Ischemic congestive cardiomyopathy
  • Ischemic dilated cardiomyopathy due to coronary artery disease
  • Left main coronary artery disease
  • Left ventricular failure with normal ejection fraction due to coronary artery disease
  • Lipid-rich atherosclerosis of coronary artery
  • Multi vessel coronary artery disease
  • Myocardial infarction due to atherothrombotic coronary artery disease
  • Myocardial ischemia due to coronary arteriosclerosis
  • Non-obstructive atherosclerosis of coronary artery
  • Obliterative coronary artery disease
  • Patient post angioplasty
  • Patient post percutaneous transluminal coronary angioplasty
  • Premature coronary artery disease
  • Recurrent coronary arteriosclerosis after percutaneous transluminal coronary angioplasty
  • Single coronary vessel disease
  • Stenosis of anterior descending branch of left coronary artery
  • Stenosis of circumflex branch of left coronary artery
  • Stenosis of coronary artery
  • Stenosis of coronary intermediate artery
  • Stenosis of diagonal branch of anterior descending branch of left coronary artery
  • Stenosis of distal portion of anterior descending branch of left coronary artery
  • Stenosis of distal portion of circumflex branch of left coronary artery
  • Stenosis of distal portion of right coronary artery
  • Stenosis of distal segment of coronary intermediate artery
  • Stenosis of distal segment of left coronary artery main stem
  • Stenosis of first diagonal branch of anterior descending branch of left coronary artery
  • Stenosis of first left posterolateral branch of circumflex branch of left coronary artery
  • Stenosis of first marginal branch of right coronary artery
  • Stenosis of first obtuse marginal branch of circumflex branch of left coronary artery
  • Stenosis of first right posterolateral branch of posterior descending branch of right coronary artery
  • Stenosis of first septal perforator branch of anterior descending branch of left coronary artery
  • Stenosis of left coronary artery main stem
  • Stenosis of left posterior descending circumflex coronary artery
  • Stenosis of left posterior lateral branch of circumflex branch of left coronary artery
  • Stenosis of marginal branch of right coronary artery
  • Stenosis of mid portion of anterior descending branch of left coronary artery
  • Stenosis of mid portion of circumflex branch of left coronary artery
  • Stenosis of mid portion of right coronary artery
  • Stenosis of mid segment of coronary intermediate artery
  • Stenosis of mid segment of left coronary artery main stem
  • Stenosis of obtuse marginal branch of circumflex branch of left coronary artery
  • Stenosis of ostium of anterior descending branch of left coronary artery
  • Stenosis of ostium of circumflex branch of left coronary artery
  • Stenosis of ostium of coronary intermediate artery
  • Stenosis of ostium of left main coronary artery
  • Stenosis of ostium of right coronary artery
  • Stenosis of posterior descending branch of right coronary artery
  • Stenosis of posterior lateral branch of right coronary artery
  • Stenosis of proximal portion of anterior descending branch of left coronary artery
  • Stenosis of proximal portion of circumflex branch of left coronary artery
  • Stenosis of proximal portion of right coronary artery
  • Stenosis of proximal segment of coronary intermediate artery
  • Stenosis of right coronary artery
  • Stenosis of second diagonal branch of anterior descending branch of left coronary artery
  • Stenosis of second left posterolateral branch of circumflex branch of left coronary artery
  • Stenosis of second marginal branch of right coronary artery
  • Stenosis of second obtuse marginal branch of circumflex branch of left coronary artery
  • Stenosis of second right posterolateral branch of posterior descending branch of right coronary artery
  • Stenosis of second septal perforator branch of anterior descending branch of left coronary artery
  • Stenosis of septal branch of anterior descending branch of left coronary artery
  • Stenosis of third diagonal branch of anterior descending branch of left coronary artery
  • Stenosis of third left posterolateral branch of circumflex branch of left coronary artery
  • Stenosis of third marginal branch of right coronary artery
  • Stenosis of third obtuse marginal branch of circumflex branch of left coronary artery
  • Stenosis of third right posterolateral branch of posterior descending branch of right coronary artery
  • Stenosis of third septal perforator branch of anterior descending branch of left coronary artery
  • Stenosis of thoracic aorta
  • Stenotic coronary artery
  • Stricture of artery
  • Subclinical atherosclerosis of artery
  • Subclinical atherosclerosis of coronary artery
  • Subclinical disease AND/OR syndrome
  • Triple vessel disease of the heart

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to I25.10: its own notes plus those printed at I25.1, I25, block I20-I25, and Chapter 9. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Atherosclerotic heart disease NOS

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From I25.1 Atherosclerotic heart disease of native coronary artery applies to 6 codes
  • atheroembolism (I75.-)
  • atherosclerosis of coronary artery bypass graft(s) and transplanted heart (I25.7-)
From I25 Chronic ischemic heart disease applies to 56 codes
  • non-ischemic myocardial injury (I5A)
From Chapter 9 (I00-I99) Diseases of the circulatory system applies to 1,433 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
  • systemic connective tissue disorders (M30-M36)
  • transient cerebral ischemic attacks and related syndromes (G45.-)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From I25.1 Atherosclerotic heart disease of native coronary artery applies to 6 codes
  • code, if applicable, to identify:
  • coronary atherosclerosis due to calcified coronary lesion (I25.84)
  • coronary atherosclerosis due to lipid rich plaque (I25.83)
From I25 Chronic ischemic heart disease applies to 56 codes
  • code to identify:
  • chronic total occlusion of coronary artery (I25.82)
  • exposure to environmental tobacco smoke (Z77.22)
  • history of tobacco dependence (Z87.891)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

From Block I20-I25 Ischemic heart diseases applies to 94 codes
  • the presence of hypertension (I10-I1A)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name I25.10, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming I25.10: they are not reported together with it, unless the two conditions are unrelated.

  • I20 Angina pectoris
    angina pectoris with atherosclerotic heart disease of native coronary arteries (I25.1-) names I25.1-, which includes this code
  • I24.0 Acute coronary thrombosis not resulting in myocardial infarction
    atherosclerotic heart disease (I25.1-) names I25.1-, which includes this code

Excludes2 7

These codes carry an Excludes2 note naming I25.10: its condition is not part of those codes, and both may be reported when the patient has both.

  • I25.81 Atherosclerosis of other coronary vessels without angina pectoris
    atherosclerotic heart disease of native coronary artery without angina pectoris (I25.10)
  • I25.5 Ischemic cardiomyopathy
    coronary atherosclerosis (I25.1-, I25.7-) names I25.1-, which includes this code
  • I70 Atherosclerosis
    arteriosclerotic cardiovascular disease (I25.1-) names I25.1-, which includes this code
  • I70 Atherosclerosis
    arteriosclerotic heart disease (I25.1-) names I25.1-, which includes this code
  • I70 Atherosclerosis
    coronary atherosclerosis (I25.1-) names I25.1-, which includes this code
  • I74 Arterial embolism and thrombosis
    coronary embolism and thrombosis (I21-I25) names I21-I25, which includes this code
  • I82 Other venous embolism and thrombosis
    coronary (I21-I25) names I21-I25, which includes this code

Code First 3

These codes say to code first a condition named in the note, and I25.10 is one of the conditions named.

  • I25.82 Chronic total occlusion of coronary artery
    coronary atherosclerosis (I25.1-, I25.7-, I25.81-) names I25.1-, which includes this code
  • I25.83 Coronary atherosclerosis due to lipid rich plaque
    coronary atherosclerosis (I25.1-, I25.7-, I25.81-) names I25.1-, which includes this code
  • I25.84 Coronary atherosclerosis due to calcified coronary lesion
    coronary atherosclerosis (I25.1-, I25.7-, I25.81-) names I25.1-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR CIR011
Coronary atherosclerosis and other heart disease
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Atherosclerosis

Atherosclerosis is a condition in which plaque builds up inside your arteries. Plaque is a sticky substance made up of cholesterol, fat, blood cells, calcium, and other substances found in the blood. Over time, plaque hardens and causes your arteries to narrow. That limits the flow of oxygen-rich blood to your body.

The full article covers:

  • What is atherosclerosis?
  • What causes atherosclerosis?
  • Who is more likely to develop atherosclerosis?
  • What are the symptoms of atherosclerosis?
  • What other problems can atherosclerosis cause?
  • How is atherosclerosis diagnosed?
  • What are the treatments for atherosclerosis?
  • Can atherosclerosis be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert I25.10 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
414.01 Crnry athrscl natve vssl
Approximate The match is approximate rather than exact.
ICD-9-CM
429.2 Ascvd
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About I25.10Overview

Is I25.10 (Atherosclerotic heart disease of native coronary artery) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report atherosclerotic heart disease of native coronary artery without angina pectoris on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does I25.10 group to?

When atherosclerotic heart disease of native coronary artery without angina pectoris is the principal diagnosis on an inpatient stay, it groups to MS-DRG 302, 303, with relative weights from 0.6610 to 1.1993 depending on complications. Higher weights mean higher Medicare reimbursement.

Who can I25.10 be reported for?

The Medicare Code Editor checks atherosclerotic heart disease of native coronary artery without angina pectoris against patient demographics: this code is intended for adult patients (age 15 through 124). Claims outside these limits are flagged as inconsistent.

Does I25.10 need an additional code?

When the condition applies, yes. The Use Additional Code note at I25.1, which applies to I25.10, reads: code, if applicable, to identify: coronary atherosclerosis due to calcified coronary lesion (I25.84); coronary atherosclerosis due to lipid rich plaque (I25.83). The additional code is reported after I25.10.

What is the ICD-9 equivalent of I25.10?

Under the General Equivalence Mappings, atherosclerotic heart disease of native coronary artery without angina pectoris converts to ICD-9-CM 414.01 (crnry athrscl natve vssl) and 429.2 (ascvd). The mapping is approximate, so confirm the match fits the documentation.

Does I25.10 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage: I25.10 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 188 (Coronary Artery Disease).