Acute myocardial infarction (I21) ICD-10-CM
The I21 code range covers acute myocardial infarction with 18 ICD-10-CM diagnosis codes. 13 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- cardiac infarction
- coronary (artery) embolism
- coronary (artery) occlusion
- coronary (artery) rupture
- coronary (artery) thrombosis
- infarction of heart, myocardium, or ventricle
- myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
- code, if applicable, to identify:
- exposure to environmental tobacco smoke Z77.22
- history of tobacco dependence Z87.891
- occupational exposure to environmental tobacco smoke Z57.31
- status post administration of tPA rtPA in a different facility within the last 24 hours prior to admission to current facility Z92.82
- tobacco dependence F17
- tobacco use Z72.0
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Codes in the I21 Range 18 codes · 13 billable
- I21 Acute myocardial infarctionNon-billable
- I21.0 ST elevation (STEMI) myocardial infarction of anterior wallNon-billable
- I21.01 ST elevation (STEMI) myocardial infarction involving left main coronary artery
- I21.02 ST elevation (STEMI) myocardial infarction involving left anterior descending coronary artery
- I21.09 ST elevation (STEMI) myocardial infarction involving other coronary artery of anterior wall
- I21.1 ST elevation (STEMI) myocardial infarction of inferior wallNon-billable
- I21.11 ST elevation (STEMI) myocardial infarction involving right coronary artery
- I21.19 ST elevation (STEMI) myocardial infarction involving other coronary artery of inferior wall
- I21.2 ST elevation (STEMI) myocardial infarction of other sitesNon-billable
- I21.21 ST elevation (STEMI) myocardial infarction involving left circumflex coronary artery
- I21.29 ST elevation (STEMI) myocardial infarction involving other sites
- I21.3 ST elevation (STEMI) myocardial infarction of unspecified site
- I21.4 Non-ST elevation (NSTEMI) myocardial infarction
- I21.9 Acute myocardial infarction, unspecified
- I21.A Other type of myocardial infarctionNon-billable
- I21.A1 Myocardial infarction type 2
- I21.A9 Other myocardial infarction type
- I21.B Myocardial infarction with coronary microvascular dysfunction
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the I21 range.
Acute Myocardial Infarction
Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations.
Non-ST Elevated Myocardial Infarction
A myocardial infarction that does not produce elevations in the ST segments of the ELECTROCARDIOGRAM. ST segment elevation of the ECG is often used in determining the treatment protocol (see also ST Elevation Myocardial Infarction).
ST Elevation Myocardial Infarction
A clinical syndrome defined by MYOCARDIAL ISCHEMIA symptoms; persistent elevation in the ST segments of the ELECTROCARDIOGRAM; and release of BIOMARKERS of myocardial NECROSIS (e.g., elevated TROPONIN levels). ST segment elevation in the ECG is often used in determining the treatment protocol (see also NON-ST ELEVATION MYOCARDIAL INFARCTION).
About the I21 Code Range
An acute myocardial infarction means heart muscle dies when its blood supply is interrupted.
The subdivisions distinguish ST-elevation (STEMI), non-ST-elevation (NSTEMI), other types, and unspecified acute infarction. STEMI codes separate the anterior wall, inferior wall, other sites, and unspecified site. More specific codes within the named sites identify an involved coronary artery. I21.4 identifies NSTEMI, while I21.9 leaves the acute infarction type unspecified.
I21.A separates type 2 from other myocardial infarction types. I21.B identifies myocardial infarction with coronary microvascular dysfunction.
Questions About This Page
How many billable codes are in the I21 range?
Of the 18 codes in this range, 13 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the I21 range classify?
The range classifies acute myocardial infarction. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.