2027 ICD-10-CM Diagnosis Code G93.49Other encephalopathy
ICD-10-CM Codes›G00–G99›G89-G99›G93
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
G93.49 is a billable ICD-10-CM diagnosis code for other encephalopathy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 70 through 72, 974 through 976. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 9 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other nervous system disorders (neither hereditary nor degenerative).
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- 4H leukodystrophy
- Acute encephalopathy with biphasic seizures and late reduced diffusion
- Adult-onset progressive leukoencephalopathy, early-onset deafness
- Amino acid below reference range
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea
- Autosomal recessive leukoencephalopathy, ischemic stroke, retinitis pigmentosa syndrome
- Autosomal recessive spastic ataxia with leukoencephalopathy
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
- Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
- Cerebral degeneration due to cerebrovascular disease
- Cerebral degeneration in childhood
- CLCN2-related leukoencephalopathy
- COL4A1-related familial vascular leukoencephalopathy
- Cystic leukoencephalopathy without megalencephaly
- Developmental delay, immunodeficiency, leukoencephalopathy, hypohomocysteinemia syndrome
- Distal spinal muscular atrophy
- Early-onset calcifying leukoencephalopathy, skeletal dysplasia
- Early-onset progressive encephalopathy, hearing loss, pons hypoplasia, brain atrophy syndrome
- Early-onset progressive encephalopathy, spastic ataxia, distal spinal muscular atrophy syndrome
- Encephalopathy caused by Influenza A virus
- Encephalopathy caused by ionizing radiation
- Familial encephalopathy with neuroserpin inclusion bodies
- Hereditary diffuse leukoencephalopathy with spheroids
- Human immunodeficiency virus leukoencephalopathy
- Hypomyelination and congenital cataract
- Infantile encephalopathy AND lactic acidosis
- Late tooth eruption
- Leukoencephalopathy
- Leukoencephalopathy co-occurrent with bilateral anterior temporal lobe cysts
- Leukoencephalopathy due to copper deficiency
- Leukoencephalopathy with brain stem and spinal cord involvement and high lactate syndrome
- Leukoencephalopathy with calcifications and cysts
- Leukoencephalopathy with metaphyseal chondrodysplasia syndrome
- Leukoencephalopathy, ataxia, hypodontia, hypomyelination syndrome
- Leukoencephalopathy, dystonia, motor neuropathy syndrome
- Leukoencephalopathy, palmoplantar keratoderma syndrome
- Leukoencephalopathy, thalamus and brainstem anomalies, high lactate syndrome
- Macroencephaly
- Megalencephalic leukoencephalopathy with subcortical cysts
- Multifactorial encephalopathy
- Progressive cavitating leukoencephalopathy
- Progressive encephalopathy with edema, hypsarrhythmia and optic atrophy syndrome
- Progressive muscular atrophy
- Punctate palmoplantar keratoderma
- PYCR2-related microcephaly, progressive leukoencephalopathy
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
- SCN2A encephalopathy
- Second cranial nerve finding
- Small vessel cerebrovascular disease
- STXBP1 developmental and epileptic encephalopathy
- Subcortical dementia
- Subcortical leukoencephalopathy
- Subcortical vascular dementia
- White matter disorder caused by infection
- White matter disorder co-occurrent and due to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to G93.49: its own notes plus those printed at G93.4 and Chapter 6. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Encephalopathy NEC
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name G93.49, its category, or a range that includes it.
Code Also 2
These codes say G93.49 may also be needed to fully describe the condition. The note gives no sequencing direction.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Leukoencephalopathy See Also: Encephalopathy; G93.49
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Leukoencephalopathies
any of various diseases affecting the white matter of the central nervous system.
Patient EducationClinical
Brain Diseases
Your brain is the control center of your body. It controls your thoughts, memory, speech, and movement. It regulates the function of many organs. It's part of your nervous system, which also includes your spinal cord and peripheral nerves. The nervous system sends signals between your brain and the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert G93.49 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About G93.49Overview
What is the ICD-10 code for other encephalopathy?
The ICD-10-CM code for other encephalopathy is G93.49 (sometimes written as G9349). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is G93.49 (Other and unspecified encephalopathy) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other encephalopathy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does G93.49 group to?
When other encephalopathy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 974, 976, 72, 975, 70, 71, with relative weights from 0.7344 to 3.0488 depending on complications. Higher weights mean higher Medicare reimbursement.
Is G93.49 a CC or MCC?
CMS lists G93.49 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 9 closely related codes in its exclusion list.
What is the ICD-9 equivalent of G93.49?
Under the General Equivalence Mappings, other encephalopathy converts to ICD-9-CM 348.39 (encephalopathy NEC). The mapping is approximate, so confirm the match fits the documentation.
