2027 ICD-10-CM Diagnosis Code E16.8Other specified disorders of pancreatic internal secretion
ICD-10-CM Codes›E00–E89›E15-E16›E16
- Billable — Valid for Submission
- Chronic Condition
E16.8 is a billable ICD-10-CM diagnosis code for other specified disorders of pancreatic internal secretion. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
E16.8 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 66 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E16.8 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Abnormal hormone secretion
- Abnormality of bombesin secretion
- Abnormality of cholecystokinin-pancreozymin secretion
- Abnormality of gastric inhibitory peptide secretion
- Abnormality of glicentin secretion
- Abnormality of motilin secretion
- Abnormality of pancreatic polypeptide secretion
- Abnormality of secretin secretion
- Abnormality of secretion of gastrin
- Abnormality of secretion of glucagon
- Abnormality of somatostatin secretion
- Abnormality of vasoactive intestinal peptide secretion
- Diminished gastrin secretion
- Excessive bombesin secretion
- Excessive cholecystokinin-pancreozymin secretion
- Excessive gastric inhibitory peptide secretion
- Excessive glicentin secretion
- Excessive motilin secretion
- Excessive pancreatic polypeptide secretion
- Excessive secretin secretion
- Excessive somatostatin secretion
- Glucagon deficiency
- Hypoinsulinemic hypoglycemia and body hemihypertrophy
- Hypoinsulinism
- Neonatal hypoglycemia
- Non-diabetic disorder of endocrine pancreas
- Verner-Morrison syndrome
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E16.8: its own notes plus those printed at Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Increased secretion from endocrine pancreas of growth hormone-releasing hormone
- Increased secretion from endocrine pancreas of pancreatic polypeptide
- Increased secretion from endocrine pancreas of somatostatin
- Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E16.8, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming E16.8: they are not reported together with it, unless the two conditions are unrelated.
- E22.0 Acromegaly and pituitary gigantismincreased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
Code First 1
These codes say to code first a condition named in the note, and E16.8 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E16.8.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disorder (of) See Also: Disease;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Pancreatic Diseases
The pancreas is a gland behind your stomach and in front of your spine. It produces juices that help break down food and hormones that help control blood sugar levels. Problems with the pancreas can lead to many health problems. These include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E16.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E16.8Overview
What is the ICD-10 code for other specified disorders of pancreatic internal secretion?
The ICD-10-CM code for other specified disorders of pancreatic internal secretion is E16.8 (sometimes written as E168). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E16.8 (Other disorders of pancreatic internal secretion) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders of pancreatic internal secretion on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E16.8 group to?
When other specified disorders of pancreatic internal secretion is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E16.8?
Under the General Equivalence Mappings, other specified disorders of pancreatic internal secretion converts to ICD-9-CM 251.8 (pancreatic disorder NEC). The mapping is approximate, so confirm the match fits the documentation.
Does E16.8 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage: E16.8 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 66 (Pancreatic Disorders and Intestinal Malabsorption, Except Pancreatitis).
