2026 ICD-10-CM Diagnosis Code E16.3Increased secretion of glucagon
ICD-10-CM Codes›E00–E89›E15-E16›E16
- Billable — Valid for Submission
- Chronic Condition
E16.3 is a billable ICD-10-CM diagnosis code for increased secretion of glucagon. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Abnormality of secretion of glucagon
- Excessive glucagon secretion
- GCGR-related hyperglucagonemia
- Glucagon resistance
- Hyperplasia of islet alpha cells with glucagon excess
- Islet cell hyperplasia
- Non-diabetic disorder of endocrine pancreas
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Hyperplasia of pancreatic endocrine cells with glucagon excess
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Abnormal, abnormality, abnormalities - See Also: Anomaly;
- glucagon secretion - E16.3
- glucagon - E16.3
- Excess, excessive, excessively
- glucagon - E16.3
- pancreatic islet cells - E16.9
- glucagon - E16.3
- glucagon - E16.3
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Abnormal, abnormality, abnormalities
- glucagon secretion
- Abnormal, abnormality, abnormalities
- secretion
- glucagon
- Excess, excessive, excessively
- glucagon
- Hyperplasia, hyperplastic
- pancreatic islet cells
- alpha
- with excess
- glucagon
- Hypersecretion
- glucagon
- Increase, increased
- secretion
- glucagon
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Pancreatic Diseases
The pancreas is a gland behind your stomach and in front of your spine. It produces juices that help break down food and hormones that help control blood sugar levels. Problems with the pancreas can lead to many health problems. These include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E16.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E16.3Overview
Is E16.3 (Other disorders of pancreatic internal secretion) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report increased secretion of glucagon on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E16.3 group to?
When increased secretion of glucagon is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E16.3?
Under the General Equivalence Mappings, increased secretion of glucagon converts to ICD-9-CM 251.4 (abn secretion glucagon). The mapping is a direct match.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
