2027 ICD-10-CM Diagnosis Code E16.1Other hypoglycemia
ICD-10-CM Codes›E00–E89›E15-E16›E16
- Billable — Valid for Submission
- Not Chronic
E16.1 is a billable ICD-10-CM diagnosis code for other hypoglycemia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Alimentary hyperinsulinemia
- Alimentary hypoglycemia
- Autoimmune hypoglycemia
- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Autosomal recessive hyperinsulinism due to Kir6.2 deficiency
- Autosomal recessive hyperinsulinism due to SUR1 deficiency
- Complication following bariatric surgery
- Diazoxide-resistant diffuse hyperinsulinism
- Diazoxide-resistant focal hyperinsulinism
- Diazoxide-resistant focal hyperinsulinism due to Kir6.2 deficiency
- Diazoxide-resistant focal hyperinsulinism due to SUR1 deficiency
- Diazoxide-resistant hyperinsulinism
- Diazoxide-sensitive diffuse hyperinsulinism
- Ectopic hyperinsulinism
- Ectopic IGF hypoglycemia
- Ectopic IGF-1 hypoglycemia
- Ectopic IGF-2 hypoglycemia
- Exercise-induced hyperinsulinism
- Familial hyperinsulinemic hypoglycemia
- Fasting hypoglycemia
- Functional hyperinsulinism
- Hyperammonemia
- Hyperglycemia due to diabetes mellitus
- Hyperinsulinemia due to malignant insulinoma
- Hyperinsulinism
- Hyperinsulinism and hyperammonemia syndrome
- Hyperinsulinism due to deficiency of glucokinase
- Hyperinsulinism due to focal adenomatous hyperplasia
- Hyperinsulinism due to HNF1A deficiency
- Hyperinsulinism due to HNF4A deficiency
- Hyperinsulinism due to insulin receptor deficiency
- Hyperinsulinism due to short chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
- Hyperinsulinism due to uncoupling protein 2 deficiency
- Hyperplasia of pancreatic islet beta cell
- Hypoglycemia
- Hypoglycemia due to neoplasm
- Hypoglycemia of childhood
- Iatrogenic hyperinsulinism
- Idiopathic postprandial hypoglycemia
- Impaired glucose tolerance with hyperinsulism
- Islet cell hyperplasia
- Ketotic hypoglycemia
- Metabolic complication of procedures
- Mixed hypoglycemia
- Neuroglycopenia
- Non-diabetic disorder of endocrine pancreas
- Non-diabetic hypoglycemia
- Post gastrointestinal tract surgery hypoglycemia
- Post-bariatric hypoglycemia
- Post-prandial hypoglycemia
- Reactive hypoglycemia
- Recurrent hypoglycemia
- Recurrent hypoglycemia in infancy
- Recurrent severe hypoglycemia
- Somogyi phenomenon
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E16.1: its own notes plus those printed at Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Functional hyperinsulinism
- Functional nonhyperinsulinemic hypoglycemia
- Hyperinsulinism NOS
- Hyperplasia of pancreatic islet beta cells NOS
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code for hypoglycemia level, if applicable (E16.A-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E16.1, its category, or a range that includes it.
Code First 1
These codes say to code first a condition named in the note, and E16.1 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E16.1.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
hyperinsulinism E16.1
posthypoglycemic (coma) E16.1
Hyperinsulinism (functional) E16.1
encephalopathy E16.1
ectopic E16.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hyperinsulinism
a syndrome with excessively high insulin levels in the blood. it may cause hypoglycemia. etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (insulinoma); autoantibodies against insulin (insulin antibodies); defective insulin receptor (insulin resistance); or overuse of exogenous insulin or hypoglycemic agents.
Patient EducationClinical
Hypoglycemia
Blood glucose, or blood sugar, is the main sugar found in your blood. It is your body's primary source of energy. It comes from the food you eat. Your body breaks down most of that food into glucose and releases it into your bloodstream. When your blood glucose goes up, it signals your pancreas to release insulin.
The full article covers:
- What is blood glucose?
- What is hypoglycemia?
- What causes hypoglycemia?
- What are the symptoms of hypoglycemia?
- How is hypoglycemia diagnosed?
- What are the treatments for hypoglycemia?
- Can hypoglycemia be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E16.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E16.1Overview
What is the ICD-10 code for other hypoglycemia?
The ICD-10-CM code for other hypoglycemia is E16.1 (sometimes written as E161). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E16.1 (Other disorders of pancreatic internal secretion) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other hypoglycemia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E16.1 group to?
When other hypoglycemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E16.1 be reported with E08.649?
Not as a rule. The Excludes1 note on E16.1 lists "diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E16.1 need an additional code?
When the condition applies, yes. The Use Additional Code note reads: code for hypoglycemia level, if applicable (E16.A-). The additional code is reported after E16.1.
