2026 ICD-10-CM Diagnosis Code E08.641Diabetes mellitus due to underlying condition with hypoglycemia with coma

ICD-10-CM Codes›E00–E89›E08-E13›E08

ICD-10-CM E08.641
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E08.641 is a billable ICD-10-CM diagnosis code for diabetes mellitus due to underlying condition with hypoglycemia with coma. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 637 through 639. The code is a manifestation code that cannot be reported as the principal diagnosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coma; stupor; and brain damage; Diabetes mellitus with complication; and Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type.

Code Identity

ICD-10-CM Code
E08.641
Billable Status
Yes — Valid for Submission
Code Describes
Diabetes mellitus due to underlying condition with hypoglycemia with coma
Short Description
Diabetes due to underlying condition w hypoglycemia w coma
Parent Code
E08.64
Diabetes mellitus due to underlying condition with hypoglycemia

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE08-E13Diabetes mellitus
CategoryE08Diabetes mellitus due to underlying condition
This CodeE08.641Diabetes mellitus due to underlying condition with hypoglycemia with coma

Code EditsBilling

Medicare Code Editor checks that affect claim validity for E08.641.

Manifestation diagnoses
Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis.

Coding GuidelinesGuidance

The diabetes mellitus codes are combination codes that include the type of diabetes mellitus, the body system affected, and the complications affecting that body system. As many codes within a particular category as are necessary to describe all of the complications of the disease may be used. They should be sequenced based on the reason for a particular encounter. Assign as many codes from categories E08 - E13 as needed to identify all of the associated conditions that the patient has.

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Diabetes, diabetic(mellitus) (sugar)
      • due to underlying condition
        • with
          • hypoglycemia
            • with coma

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS013
Coma; stupor; and brain damage
Default principal diagnosis: inpatient No · outpatient No
CCSR END003
Diabetes mellitus with complication
Default principal diagnosis: inpatient No · outpatient No
CCSR END006
Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Coma

A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E08.641 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
249.30 Sec DM ot cma nt st uncn
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E08.641Overview

Is E08.641 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report diabetes mellitus due to underlying condition with hypoglycemia with coma on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E08.641 group to?

On inpatient claims, diabetes mellitus due to underlying condition with hypoglycemia with coma maps to MS-DRG 637, 638, 639, with relative weights from 0.6212 to 1.4367 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E08.641 be a principal diagnosis?

No. This is a manifestation code: diabetes mellitus due to underlying condition with hypoglycemia with coma describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.

What is the ICD-9 equivalent of E08.641?

Under the General Equivalence Mappings, diabetes mellitus due to underlying condition with hypoglycemia with coma converts to ICD-9-CM 249.30 (sec DM ot cma nt st uncn). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.