2026 ICD-10-CM Diagnosis Code E08.52Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene

ICD-10-CM Codes›E00–E89›E08-E13›E08

ICD-10-CM E08.52
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E08.52 is a billable ICD-10-CM diagnosis code for diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 299 through 301. The code is a manifestation code that cannot be reported as the principal diagnosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diabetes mellitus with complication; Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type; and Gangrene.

Code Identity

ICD-10-CM Code
E08.52
Billable Status
Yes — Valid for Submission
Code Describes
Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene
Short Description
Diab due to undrl cond w diabetic prph angiopath w gangrene
Parent Code
E08.5
Diabetes mellitus due to underlying condition with circulatory complications

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE08-E13Diabetes mellitus
CategoryE08Diabetes mellitus due to underlying condition
This CodeE08.52Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene

Code EditsBilling

Medicare Code Editor checks that affect claim validity for E08.52.

Manifestation diagnoses
Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis.

Coding GuidelinesGuidance

The diabetes mellitus codes are combination codes that include the type of diabetes mellitus, the body system affected, and the complications affecting that body system. As many codes within a particular category as are necessary to describe all of the complications of the disease may be used. They should be sequenced based on the reason for a particular encounter. Assign as many codes from categories E08 - E13 as needed to identify all of the associated conditions that the patient has.

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Diabetes mellitus due to underlying condition with diabetic gangrene

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Diabetes, diabetic(mellitus) (sugar)
      • due to underlying condition
        • with
          • gangrene
    • Diabetes, diabetic(mellitus) (sugar)
      • due to underlying condition
        • with
          • peripheral angiopathy
            • with gangrene

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END003
Diabetes mellitus with complication
Default principal diagnosis: inpatient No · outpatient No
CCSR END006
Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type
Default principal diagnosis: inpatient No · outpatient No
CCSR CIR028
Gangrene
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Diabetes

Diabetes, also known as diabetes mellitus, is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose is your body's main source of energy. Your body can make glucose, but it also comes from the food you eat. Insulin is a hormone made by your pancreas.

The full article covers:

  • What is diabetes?
  • What are the types of diabetes?
  • What causes diabetes?
  • Who is more likely to develop diabetes?
  • What are the symptoms of diabetes?
  • How is diabetes diagnosed?
  • What are the treatments for diabetes?
  • Can diabetes be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E08.52 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
249.70 Sec DM circ nt st uncntr
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
443.81 Angiopathy in other dis
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
785.4 Gangrene
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E08.52Overview

Is E08.52 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E08.52 group to?

On inpatient claims, diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene maps to MS-DRG 299, 300, 301, with relative weights from 0.7197 to 1.6327 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E08.52 be a principal diagnosis?

No. This is a manifestation code: diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.

What is the ICD-9 equivalent of E08.52?

Under the General Equivalence Mappings, diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene converts to ICD-9-CM 249.70 (sec DM circ nt st uncntr), 443.81 (angiopathy in other dis), and 785.4 (gangrene). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.