2026 ICD-10-CM Diagnosis Code D82.3Immunodeficiency following hereditary defective response to Epstein-Barr virus

ICD-10-CM Codes›D50–D89›D80-D89›D82

ICD-10-CM D82.3
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D82.3 is a billable ICD-10-CM diagnosis code for immunodeficiency following hereditary defective response to Epstein-Barr virus. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D82.3
Billable Status
Yes — Valid for Submission
Code Describes
Immunodeficiency following hereditary defective response to Epstein-Barr virus
Short Description
Immunodef fol heredit defctv response to Epstein-Barr virus
Parent Code
D82
Immunodeficiency associated with other major defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD82Immunodeficiency associated with other major defects
This CodeD82.3Immunodeficiency following hereditary defective response to Epstein-Barr virus

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Immunodeficiency following hereditary defective response to Epstein-Barr virus
  • X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
  • X-linked lymphoproliferative disease due to SH2D1A deficiency
  • X-linked lymphoproliferative disease due to XIAP deficiency
  • X-linked lymphoproliferative syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • X-linked lymphoproliferative disease

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Disease, diseased
      • lymphoproliferative
        • X-linked
    • Immunodeficiency
      • following hereditary defective response to Epstein-Barr virus (EBV)
    • Lymphoproliferation, X-linked disease

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D82.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.8 Immune mechanism dis NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D82.3Overview

Is D82.3 (Immunodeficiency associated with other major defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report immunodeficiency following hereditary defective response to Epstein-Barr virus on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D82.3 group to?

When immunodeficiency following hereditary defective response to Epstein-Barr virus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D82.3?

Under the General Equivalence Mappings, immunodeficiency following hereditary defective response to Epstein-Barr virus converts to ICD-9-CM 279.8 (immune mechanism dis NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.