2026 ICD-10-CM Diagnosis Code D61.03Fanconi anemia

ICD-10-CM Codes›D50–D89›D60-D64›D61

ICD-10-CM D61.03
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D61.03 is a billable ICD-10-CM diagnosis code for fanconi anemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Aplastic anemia.

Code Identity

ICD-10-CM Code
D61.03
Billable Status
Yes — Valid for Submission
Code Describes
Fanconi anemia
Short Description
Fanconi anemia
Same as the full description in the CMS dataset.
Parent Code
D61.0
Constitutional aplastic anemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD60-D64Aplastic and other anemias and other bone marrow failure syndromes
CategoryD61Other aplastic anemias and other bone marrow failure syndromes
This CodeD61.03Fanconi anemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Fanconi pancytopenia
  • Fanconi's anemia

Type 1 Excludes

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • Fanconi ('s)
    • Disease, diseased
      • Fanconi ('s)
    • Fanconi('s) anemia
    • Fanconi hypoplastic anemia
    • Fanconi panmyelopathy
    • Pancytopenia(acquired)
      • Fanconi

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD003
Aplastic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • BRCA2 Protein

    a large, nuclear protein, encoded by the brca2 gene (gene, brca2). mutations in this gene predispose humans to breast and ovarian cancer. the brca2 protein is an essential component of dna repair pathways, suppressing the formation of gross chromosomal rearrangements. (from genes dev. 2000;14(11):1400-6)

  • Fanconi Anemia

    congenital disorder affecting all bone marrow elements, resulting in anemia; leukopenia; and thrombopenia, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. spontaneous chromosome breakage is a feature of this disease along with predisposition to leukemia. there are at least 7 complementation groups in fanconi anemia: fanca, fancb, fancc, fancd1, fancd2, fance, fancf, fancg, and fancl. (from online mendelian inheritance in man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, august 20, 2004)

  • Fanconi Anemia Complementation Group A Protein

    a fanconi anemia complementation group protein that is the most commonly mutated protein in fanconi anemia. it undergoes phosphorylation by protein kinase b and forms a complex with fancc protein in the cell nucleus.

  • Fanconi Anemia Complementation Group C Protein

    a fanconi anemia complementation group protein that regulates the activities of cytochrome p450 reductase and glutathione s-transferase. it is found predominately in the cytoplasm, but moves to the cell nucleus in response to fance protein.

  • Fanconi Anemia Complementation Group D2 Protein

    a fanconi anemia complementation group protein that undergoes mono-ubiquitination by fancl protein in response to dna damage. also, in response to ionizing radiation it can undergo phosphorylation by ataxia telangiectasia mutated protein. modified fancd2 interacts with brca2 protein in a stable complex with chromatin, and it is involved in dna repair by homologous recombination.

  • Fanconi Anemia Complementation Group E Protein

    a fanconi anemia complementation group protein that interacts with fancc protein and fancd2 protein. it promotes the accumulation of fancc protein in the cell nucleus.

  • Fanconi Anemia Complementation Group F Protein

    a fanconi anemia complementation group protein. it is an essential component of a nuclear core complex that protects the genome against chromosomal instability. it interacts directly with fancg protein and helps stabilize a complex with fanca protein and fancc protein.

  • Fanconi Anemia Complementation Group G Protein

    a fanconi anemia complementation group protein that undergoes phosphorylation by cdc2 protein kinase during mitosis. it forms a complex with other fanconi anemia proteins and helps protect cells from dna damage by genotoxic agents.

  • Fanconi Anemia Complementation Group L Protein

    an e3 ubiquitin ligase that plays a key role in the dna damage response pathway of fanconi anemia proteins. it is associated with mono-ubiquitination of fancd2 protein and the redistribution of fancd2 to nuclear foci containing brca1 protein.

  • Fanconi Anemia Complementation Group N Protein

    a fanconi anemia complementation group protein that contains an n-terminal dna-binding region and seven, c-terminal, wd repeats. it is an essential factor in homologous recombination dna repair through its interactions with brca2 protein; rad51 recombinase; and brca1 protein. it functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. mutations in the palb2 gene are associated with fanconi anemia complementation group n; type 3 pancreatic neoplasms; and susceptibility to breast cancer.

  • Fanconi Anemia Complementation Group Proteins

    a diverse group of proteins whose genetic mutations have been associated with the chromosomal instability syndrome fanconi anemia. many of these proteins play important roles in protecting cells against oxidative stress.

Code History & ChangesHistory

Replacement D61.03 replaces the following previously assigned code(s):

  • D61.09 - Other constitutional aplastic anemia
FY 2025AddedAdded to the ICD-10-CM code setEffective October 1, 2024.
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D61.03Overview

Is D61.03 (Constitutional aplastic anemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report fanconi anemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D61.03 group to?

When fanconi anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.