2026 ICD-10-CM Diagnosis Code D55.29Anemia due to other disorders of glycolytic enzymes
ICD-10-CM Codes›D50–D89›D55-D59›D55
- Billable — Valid for Submission
- Chronic Condition
D55.29 is a billable ICD-10-CM diagnosis code for anemia due to other disorders of glycolytic enzymes. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as hemolytic anemia due to glyceraldehyde-3-phosphate dehydrogenase deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Hemolytic anemia due to glyceraldehyde-3-phosphate dehydrogenase deficiency
- Hemolytic anemia due to hexokinase deficiency
- Hemolytic anemia due to red cell enolase deficiency
- Hemolytic anemia due to triose phosphate isomerase deficiency
- HNSHA due to glucose phosphate isomerase deficiency
- HNSHA due to hexokinase deficiency
- HNSHA due to NADH diaphorase deficiency
- HNSHA due to phosphofructokinase deficiency
- HNSHA due to phosphoglycerate kinase deficiency
- HNSHA due to triosephosphate isomerase deficiency
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Hexokinase deficiency anemia
- Triose-phosphate isomerase deficiency anemia
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) - D64.9
- anaerobic glycolysis - D55.29
- deficiency - D53.9
- 2, 3 diphosphoglycurate mutase - D55.29
- 2, 3 PG - D55.29
- glycolytic - D55.29
- glyceraldehyde phosphate dehydrogenase - D55.29
- hexokinase - D55.29
- phosphofructo-aldolase - D55.29
- phosphoglycerate kinase - D55.29
- triose-phosphate isomerase - D55.29
- hexokinase deficiency - D55.29
- Disorder (of) - See Also: Disease;
- anaerobic glycolysis with anemia - D55.29
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- with (due to) (in)
- disorder of
- anaerobic glycolysis
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- 2, 3 diphosphoglycurate mutase
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- 2, 3 PG
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- enzyme
- glycolytic
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- glyceraldehyde phosphate dehydrogenase
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- hexokinase
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- phosphofructo-aldolase
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- phosphoglycerate kinase
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- deficiency
- triose-phosphate isomerase
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- hemolytic
- nonspherocytic
- congenital or hereditary NEC
- type
- II
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- hemolytic
- nonspherocytic
- type
- II
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- hexokinase deficiency
- Disorder(of)
- anaerobic glycolysis with anemia
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement D55.29 replaces the following previously assigned code(s):
- D55.2 - Anemia due to disorders of glycolytic enzymes
Questions About D55.29Overview
Is D55.29 (Anemia due to disorders of glycolytic enzymes) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report anemia due to other disorders of glycolytic enzymes on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D55.29 group to?
When anemia due to other disorders of glycolytic enzymes is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
