2026 ICD-10-CM Diagnosis Code D36.10Benign neoplasm of peripheral nerves and autonomic nervous system, unspecified

AHRQ’s CCSR groups this code into broader clinical categories.

• Ganglioneuroma

  a benign neoplasm that usually arises from the sympathetic trunk in the mediastinum. histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. the tumor may present clinically with horner syndrome or diarrhea due to ectopic production of vasoactive intestinal peptide. (from devita et al., cancer: principles and practice of oncology, 5th ed, p966)

• Genes, Neurofibromatosis 1

  tumor suppressor genes located on the long arm of human chromosome 17 in the region 17q11.2. mutation of these genes is thought to cause neurofibromatosis 1, watson syndrome, and leopard syndrome.

• Genes, Neurofibromatosis 2

  tumor suppressor genes located on the long arm of human chromosome 22. mutation or loss of these genes causes neurofibromatosis 2.

• Neurofibroma

  a moderately firm, benign, encapsulated tumor resulting from proliferation of schwann cells and fibroblasts that includes portions of nerve fibers. the tumors usually develop along peripheral or cranial nerves and are a central feature of neurofibromatosis 1, where they may occur intracranially or involve spinal roots. pathologic features include fusiform enlargement of the involved nerve. microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (from adams et al., principles of neurology, 6th ed, p1016)

• Neurofibroma, Plexiform

  a type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. the tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. this process is almost always a manifestation of neurofibromatosis 1. (from adams et al., principles of neurology, 6th ed, p1016; j pediatr 1997 nov;131(5):678-82)

• Neurofibromatoses

  a group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. neurofibromatosis 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., neurofibromatosis 2, neurofibromatosis 3, etc.) have been described. (from neurochirurgie 1998 nov;44(4):267-72)

• Neurofibromatosis 1

  an autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic neural crest. multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. peripheral and central nervous system neoplasms occur frequently, especially optic nerve glioma and neurofibrosarcoma. nf1 is caused by mutations which inactivate the nf1 gene (genes, neurofibromatosis 1) on chromosome 17q. the incidence of learning disabilities is also elevated in this condition. (from adams et al., principles of neurology, 6th ed, pp1014-18) there is overlap of clinical features with noonan syndrome in a syndrome called neurofibromatosis-noonan syndrome. both the ptpn11 and nf1 gene products are involved in the signal transduction pathway of ras (ras proteins).

• Neurofibromatosis 2

  an autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (neurilemmoma) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. the disease has been linked to mutations of the nf2 gene (genes, neurofibromatosis 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.

• Neurofibromin 1

  a protein found most abundantly in the nervous system. defects or deficiencies in this protein are associated with neurofibromatosis 1, watson syndrome, and leopard syndrome. mutations in the gene (gene, neurofibromatosis 1) affect two known functions: regulation of ras-gtpase and tumor suppression.

• Neurofibromin 2

  a membrane protein homologous to the erm (ezrin-radixin-moesin) family of cytoskeleton-associated proteins which regulate physical properties of membranes. alterations in neurofibromin 2 are the cause of neurofibromatosis 2.

• Cranial Nerve Neoplasms

  benign and malignant neoplasms that arise from one or more of the twelve cranial nerves.

• Morton Neuroma

  a nerve inflammation in the foot caused by chronic compression of the plantar nerve between the metatarsal bones.

• Multiple Endocrine Neoplasia Type 2b

  similar to men2a, it is also caused by mutations of the men2 gene, also known as the ret proto-oncogene. its clinical symptoms include medullary carcinoma (carcinoma, medullary) of thyroid gland and pheochromocytoma of adrenal medulla (50%). unlike men2a, men2b does not involve parathyroid neoplasms. it can be distinguished from men2a by its neural abnormalities such as mucosal neuromas on eyelids; lip; and tongue, and ganglioneuromatosis of gastrointestinal tract leading to megacolon. it is an autosomal dominant inherited disease.

• Neuroma

  a tumor made up of nerve cells and nerve fibers. (dorland, 27th ed)

• Neuroma, Acoustic

  a benign schwannoma of the eighth cranial nerve (vestibulocochlear nerve), mostly arising from the vestibular branch (vestibular nerve) during the fifth or sixth decade of life. clinical manifestations include hearing loss; headache; vertigo; tinnitus; and facial pain. bilateral acoustic neuromas are associated with neurofibromatosis 2. (from adams et al., principles of neurology, 6th ed, p673)

• Horner Syndrome

  a syndrome associated with defective sympathetic innervation to one side of the face, including the eye. clinical features include miosis; mild blepharoptosis; and hemifacial anhidrosis (decreased sweating)(see hypohidrosis). lesions of the brain stem; cervical spinal cord; first thoracic nerve root; apex of the lung; carotid artery; cavernous sinus; and apex of the orbit may cause this condition. (from miller et al., clinical neuro-ophthalmology, 4th ed, pp500-11)

• Metatarsal Bones

  the five long bones of the metatarsus, articulating with the tarsal bones proximally and the phalanges of toes distally.

• Lipomatosis of Nerve|Fibrolipomatous Hamartoma of Peripheral Nerve|Neural Fibrolipoma|Peripheral Nerve Fibrolipomatous Hamartoma

  a tumor composed of mature adipocytes and fibrous tissue infiltrating the epineurium and peripheral nerves. it is often seen at birth or during childhood and may be associated with macrodactyly.

• Lipomatous Hamartoma

  a benign hamartomatous lesion composed predominantly of adipose tissue.

• Thymolipoma|Thymolipomatous Hamartoma

  a well-circumscribed tumor of the thymus composed of islands of normal thymic parenchyma and mature adipose tissue. it is not clear if thymolipoma is a neoplastic or non-neoplastic lesion.

• Epithelioid Neurofibroma

  a rare neurofibroma with epithelioid morphology.

• Cellular Neurofibroma

  a neurofibroma characterized by the presence of areas with increased cellularity.

• Microcystic/Reticular Schwannoma

  the rarest histopathologic subtype of schwannoma. the reported cases have been located in the gastrointestinal submucosa or subcutaneous tissue. morphologically it is characterized by the presence of a microcyst-rich network of spindle cells with minimal amount of cytoplasm and antoni a tissue.

• Epithelioid Schwannoma

  a schwannoma characterized by the presence of epithelioid cells with eosinophilic cytoplasm, within a myxoid and/or hyalinized stroma.

• Solitary Neurofibroma

  a neurofibroma that manifests as a single mass.

• Dermal Nerve Sheath Myxoma

  a benign neoplasm with nerve sheath features that arises from the dermis and subcutaneous tissue. it manifests as an asymptomatic nodule and most often arises from the extremities. it is composed of spindle and epithelioid cells in a myxoid stroma.

Anatomical sites in the Table of Neoplasms that reference this code family.

Autonomic Nervous System Disorders

Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.