2026 ICD-10-CM Diagnosis Code D21Other benign neoplasms of connective and other soft tissue

ICD-10-CM Codes›C00–D49›D10-D36›D21

ICD-10-CM D21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D21 is a non-billable ICD-10-CM category code for other benign neoplasms of connective and other soft tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as D21.0, D21.10, D21.11, and D21.12.

Code Identity

ICD-10-CM Code
D21
Billable Status
No — Non-Billable Category
Code Describes
Other benign neoplasms of connective and other soft tissue
Chapter
D10-D36
Benign neoplasms, except benign neuroendocrine tumors

Code Classification

ChapterC00–D49Neoplasms
SectionD10-D36Benign neoplasms, except benign neuroendocrine tumors
CategoryD21Other benign neoplasms of connective and other soft tissue
This CodeD21Other benign neoplasms of connective and other soft tissue

Specific Coding for Other benign neoplasms of connective and other soft tissueOverview

Non-specific codes like D21 require more characters. Use one of these billable codes instead:

  • Use D21.0 for Benign neoplasm of connective and other soft tissue of head, face and neck

  • D21.1 for Benign neoplasm of connective and other soft tissue of upper limb, including shoulder

  • Use D21.10 for Benign neoplasm of connective and other soft tissue of unspecified upper limb, including shoulder

  • Use D21.11 for Benign neoplasm of connective and other soft tissue of right upper limb, including shoulder

  • Use D21.12 for Benign neoplasm of connective and other soft tissue of left upper limb, including shoulder

  • D21.2 for Benign neoplasm of connective and other soft tissue of lower limb, including hip

  • Use D21.20 for Benign neoplasm of connective and other soft tissue of unspecified lower limb, including hip

  • Use D21.21 for Benign neoplasm of connective and other soft tissue of right lower limb, including hip

  • Use D21.22 for Benign neoplasm of connective and other soft tissue of left lower limb, including hip

  • Use D21.3 for Benign neoplasm of connective and other soft tissue of thorax

  • Use D21.4 for Benign neoplasm of connective and other soft tissue of abdomen

  • Use D21.5 for Benign neoplasm of connective and other soft tissue of pelvis

  • Use D21.6 for Benign neoplasm of connective and other soft tissue of trunk, unspecified

  • Use D21.9 for Benign neoplasm of connective and other soft tissue, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Includes

  • benign neoplasm of blood vessel
  • benign neoplasm of bursa
  • benign neoplasm of cartilage
  • benign neoplasm of fascia
  • benign neoplasm of fat
  • benign neoplasm of ligament, except uterine
  • benign neoplasm of lymphatic channel
  • benign neoplasm of muscle
  • benign neoplasm of synovia
  • benign neoplasm of tendon (sheath)
  • benign stromal tumors

Type 1 Excludes

  • benign neoplasm of articular cartilage D16
  • benign neoplasm of cartilage of larynx D14.1
  • benign neoplasm of cartilage of nose D14.0
  • benign neoplasm of connective tissue of breast D24
  • benign neoplasm of peripheral nerves and autonomic nervous system D36.1
  • benign neoplasm of peritoneum D20.1
  • benign neoplasm of retroperitoneum D20.0
  • benign neoplasm of uterine ligament, any D28.2
  • benign neoplasm of vascular tissue D18
  • hemangioma D18.0
  • lipomatous neoplasm D17
  • lymphangioma D18.1
  • uterine leiomyoma D25

Patient EducationClinical

Benign Tumors

Tumors are abnormal growths in your body. They can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Benign tumors grow only in one place. They cannot spread or invade other parts of your body. Even so, they can be dangerous if they press on vital organs, such as your brain.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D21Overview

Is D21 (Other benign neoplasms of connective and other soft tissue) a billable code?

No. This is a category header that groups the codes for other benign neoplasms of connective and other soft tissue, and headers cannot be submitted on claims. Claims for other benign neoplasms of connective and other soft tissue need a more specific code from this category, such as D21.0, D21.10, and D21.11.