2026 ICD-10-CM Diagnosis Code C96.5Multifocal and unisystemic Langerhans-cell histiocytosis
ICD-10-CM Codes›C00–D49›C81-C96›C96
- Billable — Valid for Submission
- Chronic Condition
C96.5 is a billable ICD-10-CM diagnosis code for multifocal and unisystemic Langerhans-cell histiocytosis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as bone xanthoma. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Non-Hodgkin lymphoma.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Bone xanthoma
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Hand-Schüller-Christian disease
- Histiocytosis X, multifocal
Type 1 Excludes
- multifocal and multisystemic disseminated Langerhans-cell histiocytosis C96.0
- unifocal Langerhans-cell histiocytosis C96.6
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Histiocytosis - D76.3
- Langerhans' cell NEC - C96.6
- unisystemic - C96.5
- multifocal - C96.5
- Schüller-Christian disease or syndrome - C96.5
- Syndrome - See Also: Disease;
- Schüller-Christian - C96.5
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Hand-Schüller-Christian disease or syndrome
- Histiocytosis
- Langerhans' cell NEC
- multifocal X
- unisystemic
- Histiocytosis
- X NEC
- multifocal
- Schüller-Christian disease or syndrome
- Syndrome
- Schüller-Christian
- Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
- bone (generalisata)
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Langerhans cell histiocytosis
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C96.5 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C96.5Overview
Is C96.5 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report multifocal and unisystemic Langerhans-cell histiocytosis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What is the ICD-9 equivalent of C96.5?
Under the General Equivalence Mappings, multifocal and unisystemic Langerhans-cell histiocytosis converts to ICD-9-CM 277.89 (metabolism disorder NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
