2027 ICD-10-CM Diagnosis Code C95.01Acute leukemia of unspecified cell type, in remission
ICD-10-CM Codes›C00–D49›C81-C96›C95
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 18
- Chronic Condition
C95.01 is a billable ICD-10-CM diagnosis code for acute leukemia of unspecified cell type, in remission. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 820 through 822, 834 through 839, 850. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 113 closely related codes. Coders also document this condition as acute leukemia in remission. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Leukemia in remission.
For Medicare Advantage risk adjustment, C95.01 maps to CMS-HCC Category 18 (Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid) under the V28 model, adding a risk factor of about 2.341 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C95.01 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acute leukemia in remission
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to C95.01: its own notes plus those printed at C95.0, C95, block C81-C96, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- acute exacerbation of unspecified chronic leukemia (C95.10)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name C95.01, its category, or a range that includes it.
Applicable To 2
These notes mention C95.01.
Excludes1 4
These codes carry an Excludes1 note naming C95.01: they are not reported together with it, unless the two conditions are unrelated.
Code First 3
These codes say to code first a condition named in the note, and C95.01 is one of the conditions named.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acute Leukemia in Remission
a finding of acute leukemia that is not growing and responds to treatment.
Patient EducationClinical
Leukemia
Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job:
The full article covers:
- What is leukemia?
- What are the types of leukemia?
- What causes leukemia?
- Who is at risk for leukemia?
- What are the symptoms of leukemia?
- How is leukemia diagnosed?
- What are the treatments for leukemia?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C95.01 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C95.01Overview
What is the ICD-10 code for acute leukemia of unspecified cell type, in remission?
The ICD-10-CM code for acute leukemia of unspecified cell type, in remission is C95.01 (sometimes written as C9501). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is C95.01 (Acute leukemia of unspecified cell type) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report acute leukemia of unspecified cell type, in remission on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does C95.01 group to?
When acute leukemia of unspecified cell type, in remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 834, 837, 821, 822, 836, 839, 838, 850, 835, 820, with relative weights from 1.1267 to 8.4076 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C95.01 a CC or MCC?
CMS lists C95.01 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 113 closely related codes in its exclusion list.
Can C95.01 be reported with C95.10?
Not as a rule. The Excludes1 note at C95.0, which applies to C95.01, lists "acute exacerbation of unspecified chronic leukemia (C95.10)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is C95.01?
C95.01 (acute leukemia of unspecified cell type, in remission) maps to CMS-HCC Category 18 (Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid), commonly written as HCC 18, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 8 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 19.
Does C95.01 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C95.01 adds a risk adjustment factor of about 2.341 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 1.110 to 2.537 depending on the payment segment). A more severe related category (HCC 17) supersedes it when both are reported. See the full factor table on the HCC 18 category page.
