2026 ICD-10-CM Diagnosis Code C78.7Secondary malignant neoplasm of liver and intrahepatic bile duct

ICD-10-CM Codes›C00–D49›C76-C80›C78

ICD-10-CM C78.7
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C78.7 is a billable ICD-10-CM diagnosis code for secondary malignant neoplasm of liver and intrahepatic bile duct. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 435 through 437. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Secondary malignancies.

Code Identity

ICD-10-CM Code
C78.7
Billable Status
Yes — Valid for Submission
Code Describes
Secondary malignant neoplasm of liver and intrahepatic bile duct
Short Description
Secondary malig neoplasm of liver and intrahepatic bile duct
Parent Code
C78
Secondary malignant neoplasm of respiratory and digestive organs

Code Classification

ChapterC00–D49Neoplasms
SectionC76-C80Malignant neoplasms of ill-defined, other secondary and unspecified sites
CategoryC78Secondary malignant neoplasm of respiratory and digestive organs
This CodeC78.7Secondary malignant neoplasm of liver and intrahepatic bile duct

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Lymphoma finding
  • Lymphoma involves liver
  • Malignant neoplasm of intrahepatic bile duct
  • Metastatic carcinoma to biliary tract
  • Metastatic carcinoma to intrahepatic bile duct
  • Metastatic carcinoma to liver
  • Metastatic malignant neoplasm to intrahepatic bile ducts
  • Metastatic malignant neoplasm to liver
  • Metastatic Merkel cell carcinoma to liver
  • Metastatic nuclear protein in testis associated carcinoma to liver
  • Metastatic small cell neuroendocrine carcinoma
  • Metastatic small cell neuroendocrine carcinoma to liver
  • Metastatic squamous cell carcinoma to liver
  • Metastatic squamous cell carcinoma to liver and intrahepatic biliary tract
  • Metastatic undifferentiated carcinoma to liver and intrahepatic biliary tract
  • Neuroendocrine neoplasm of liver
  • NUT carcinoma
  • Squamous cell carcinoma of liver and intrahepatic biliary tract
  • Undifferentiated carcinoma of liver and intrahepatic biliary tract

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO070
Secondary malignancies
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hep G2 Cells

    a human liver tumor cell line used to study a variety of liver-specific metabolic functions.

  • Hepatoblastoma

    a malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (stedman, 25th ed)

  • Lymphoma Finding

    a term that refers to clinicopathologic findings related to lymphomas.

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
bile or biliary (tract) › canaliculi (biliferi) (intrahepatic)C22.1C78.7D01.5D13.4D37.6D49.0
bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › intrahepaticC22.1C78.7D01.5D13.4D37.6D49.0
canaliculi, biliary (biliferi) (intrahepatic)C22.1C78.7D01.5D13.4D37.6D49.0
gall duct (extrahepatic) › intrahepaticC22.1C78.7D01.5D13.4D37.6D49.0
hepatic [See Also: Index to disease, by histology]C22.9C78.7D01.5D13.4D37.6D49.0
hepatic [See Also: Index to disease, by histology] › primaryC22.8C78.7D01.5D13.4D37.6D49.0
hepatoblastomaC22.2C78.7D01.5D13.4D37.6D49.0
hepatomaC22.0C78.7D01.5D13.4D37.6D49.0
intrahepatic (bile) ductC22.1C78.7D01.5D13.4D37.6D49.0
liver [See Also: Index to disease, by histology]C22.9C78.7D01.5D13.4D37.6D49.0
liver [See Also: Index to disease, by histology] › primaryC22.8C78.7D01.5D13.4D37.6D49.0

Patient EducationClinical

Liver Cancer

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert C78.7 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
197.7 Second malig neo liver
Approximate The match is approximate rather than exact.
ICD-9-CM
197.8 Sec mal neo GI NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C78.7Overview

Is C78.7 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report secondary malignant neoplasm of liver and intrahepatic bile duct on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C78.7 group to?

When secondary malignant neoplasm of liver and intrahepatic bile duct is the principal diagnosis on an inpatient stay, it groups to MS-DRG 435, 436, 437, with relative weights from 0.8533 to 1.8367 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C78.7?

Under the General Equivalence Mappings, secondary malignant neoplasm of liver and intrahepatic bile duct converts to ICD-9-CM 197.7 (second malig neo liver) and 197.8 (sec mal neo GI NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.