2026 ICD-10-CM Diagnosis Code C25.9Malignant neoplasm of pancreas, unspecified

AHRQ’s CCSR groups this code into broader clinical categories.

• Carcinoma, Pancreatic Ductal

  carcinoma that arises from the pancreatic ducts. it accounts for the majority of cancers derived from the pancreas.

• Cystic Fibrosis

  an autosomal recessive genetic disease of the exocrine glands. it is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator expressed in several organs including the lung, the pancreas, the biliary system, and the sweat glands. cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in airway obstruction; chronic respiratory infections; pancreatic insufficiency; maldigestion; salt depletion; and heat prostration.

• Insulin Infusion Systems

  portable or implantable devices for infusion of insulin. includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor.

• Islets of Langerhans

  irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the pancreas among the exocrine acini. each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. there are four major cell types. the most abundant beta cells (50-80%) secrete insulin. alpha cells (5-20%) secrete glucagon. pp cells (10-35%) secrete pancreatic polypeptide. delta cells (~5%) secrete somatostatin.

• Nesidioblastosis

  an inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the pancreas and congenital hyperinsulinism. it is due to focal hyperplasia of pancreatic islet cells budding off from the ductal structures and forming new islets of langerhans. mutations in the islet cells involve the potassium channel gene kcnj11 or the atp-binding cassette transporter gene abcc8, both on chromosome 11.

• Pancreas

  a nodular organ in the abdomen that contains a mixture of endocrine glands and exocrine glands. the small endocrine portion consists of the islets of langerhans secreting a number of hormones into the blood stream. the large exocrine portion (exocrine pancreas) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the duodenum.

• Pancreas Divisum

  anatomic variants in pancreatic ducts characterized by failure of fusion of the ventral and dorsal endodermal buds. pancreas divisum results in inadequate or no communication between dorsal and ventral ducts. while most cases are asymptomatic, it may be associated with recurrent pancreatitis.

• Pancreas Transplantation

  the transference of a pancreas from one human or animal to another.

• Pancreas, Artificial

  devices for simulating the activity of the pancreas. they can be either electromechanical, consisting of a glucose sensor, computer, and insulin pump or bioartificial, consisting of isolated islets of langerhans in an artificial membrane.

• Pancreas, Exocrine

  the major component (about 80%) of the pancreas composed of acinar functional units of tubular and spherical cells. the acinar cells synthesize and secrete several digestive enzymes such as trypsinogen; lipase; amylase; and ribonuclease. secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the duodenum.

• Pancreatic Neoplasms

  tumors or cancer of the pancreas. depending on the types of islet cells present in the tumors, various hormones can be secreted: glucagon from pancreatic alpha cells; insulin from pancreatic beta cells; and somatostatin from the somatostatin-secreting cells. most are malignant except the insulin-producing tumors (insulinoma).

• Pancrelipase

  a preparation of hog pancreatic enzymes standardized for lipase content.

• Shwachman-Diamond Syndrome

  an inherited syndrome characterized by exocrine pancreatic insufficiency; hematologic abnormalities (e.g., bone marrow hypoplasia), and skeletal abnormalities (e.g., metaphyseal chondroplasia). germline mutations in the sbds gene are associated with shwachman-diamond syndrome.

• Childhood Pancreatoblastoma|Pediatric Pancreatoblastoma

  a pancreatoblastoma that occurs during childhood. it is the most common malignant pancreatic neoplasm in children younger than ten years of age.

• Pancreatoblastoma

  a rare malignant epithelial neoplasm arising from the pancreas. the vast majority of cases occur during childhood. it is characterized by acinar differentiation, the formation of squamoid corpuscles, and the formation of stromal bands. patients may present with an abdominal mass. symptoms include pain, weight loss, and diarrhea. it may metastasize to lymph nodes, liver, and distant anatomic sites. children who do not have metastatic disease at the time of diagnosis usually have a favorable clinical outcome when treated with a combination of surgery and chemotherapy. however, children with metastatic disease at presentation or adult patients usually have a poor prognosis.

Anatomical sites in the Table of Neoplasms that reference this code family.

Pancreatic Cancer

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include:

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