2026 ICD-10-CM Diagnosis Code A52.15Late syphilitic neuropathy

ICD-10-CM Codes›A00–B99›A50-A64›A52

ICD-10-CM A52.15
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

A52.15 is a billable ICD-10-CM diagnosis code for late syphilitic neuropathy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Polyneuropathies and Sexually transmitted infections (excluding HIV and hepatitis).

Code Identity

ICD-10-CM Code
A52.15
Billable Status
Yes — Valid for Submission
Code Describes
Late syphilitic neuropathy
Short Description
Late syphilitic neuropathy
Same as the full description in the CMS dataset.
Parent Code
A52.1
Symptomatic neurosyphilis

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionA50-A64Infections with a predominantly sexual mode of transmission
CategoryA52Late syphilis
This CodeA52.15Late syphilitic neuropathy

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acoustic neuritis
  • Bacterial infection of peripheral nerve
  • Infection causing inflammation of optic nerve
  • Optic atrophy due to late syphilis
  • Retrobulbar neuritis
  • Retrobulbar neuritis due to late syphilis
  • Secondary neurosyphilis
  • Secondary syphilis of nervous system
  • Syphilitic acoustic neuritis
  • Syphilitic acoustic neuritis - quaternary stage
  • Syphilitic optic atrophy
  • Syphilitic polyneuropathy
  • Syphilitic retrobulbar neuritis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Late syphilitic acoustic neuritis
  • Late syphilitic optic (nerve) atrophy
  • Late syphilitic polyneuropathy
  • Late syphilitic retrobulbar neuritis

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Atrophy, atrophic(of)
      • nerve
        • optic (papillomacular bundle)
          • syphilitic (late)
    • Atrophy, atrophic(of)
      • optic (nerve)
        • syphilitic (late)
    • Deafness(acquired) (complete) (hereditary) (partial)
      • syphilitic
    • Disturbance(s)
      • neuromuscular mechanism (eye), due to syphilis
    • Neuritis(rheumatoid)
      • acoustic (nerve)
        • syphilitic
    • Neuritis(rheumatoid)
      • retrobulbar
        • in (due to)
          • late syphilis
    • Neuritis(rheumatoid)
      • retrobulbar
        • syphilitic
    • Neuritis(rheumatoid)
      • syphilitic
    • Neurosyphilis(arrested) (early) (gumma) (late) (latent) (recurrent) (relapse)
      • optic atrophy
    • Paralysis, paralytic(complete) (incomplete)
      • nerve
        • syphilitic
    • Polyneuropathy(peripheral)
      • in (due to)
        • syphilis (late)
    • Polyneuropathy(peripheral)
      • syphilitic (late)
    • Syphilis, syphilitic(acquired)
      • acoustic nerve
    • Syphilis, syphilitic(acquired)
      • cerebral
        • nerves (multiple palsies)
    • Syphilis, syphilitic(acquired)
      • cranial nerve
    • Syphilis, syphilitic(acquired)
      • cranial nerve
        • multiple palsies
    • Syphilis, syphilitic(acquired)
      • ear
        • inner
          • nerve (eighth)
    • Syphilis, syphilitic(acquired)
      • ear
        • inner
          • neurorecurrence
    • Syphilis, syphilitic(acquired)
      • eighth nerve (neuritis)
    • Syphilis, syphilitic(acquired)
      • nerve palsy (any cranial nerve)
    • Syphilis, syphilitic(acquired)
      • nerve palsy (any cranial nerve)
        • multiple
    • Syphilis, syphilitic(acquired)
      • neuritis
    • Syphilis, syphilitic(acquired)
      • neuritis
        • acoustic
    • Syphilis, syphilitic(acquired)
      • optic nerve (atrophy) (neuritis) (papilla)
    • Syphilis, syphilitic(acquired)
      • retrobulbar neuritis
    • Syphilis, syphilitic(acquired)
      • seventh nerve (paralysis)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS015
Polyneuropathies
Default principal diagnosis: inpatient No · outpatient No
CCSR INF010
Sexually transmitted infections (excluding HIV and hepatitis)
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Syphilis

Syphilis is a sexually transmitted infection (STI) caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert A52.15 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
094.84 Syphilitic optic atrophy
Approximate The match is approximate rather than exact.
ICD-9-CM
094.85 Syph retrobulb neuritis
Approximate The match is approximate rather than exact.
ICD-9-CM
094.86 Syphil acoustic neuritis
Approximate The match is approximate rather than exact.
ICD-9-CM
094.89 Neurosyphilis NEC
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
357.4 Neuropathy in other dis
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About A52.15Overview

Is A52.15 (Symptomatic neurosyphilis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report late syphilitic neuropathy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of A52.15?

Under the General Equivalence Mappings, late syphilitic neuropathy converts to ICD-9-CM 094.84 (syphilitic optic atrophy), 094.85 (syph retrobulb neuritis), and 094.86 (syphil acoustic neuritis). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.