Late syphilis (A52) ICD-10-CM
The A52 code range covers late syphilis with 34 ICD-10-CM diagnosis codes. 30 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the A52 Range 34 codes · 30 billable
- A52 Late syphilisNon-billable
- A52.0 Cardiovascular and cerebrovascular syphilisNon-billable
- A52.00 Cardiovascular syphilis, unspecified
- A52.01 Syphilitic aneurysm of aorta
- A52.02 Syphilitic aortitis
- A52.03 Syphilitic endocarditis
- A52.04 Syphilitic cerebral arteritis
- A52.05 Other cerebrovascular syphilis
- A52.06 Other syphilitic heart involvement
- A52.09 Other cardiovascular syphilis
- A52.1 Symptomatic neurosyphilisNon-billable
- A52.10 Symptomatic neurosyphilis, unspecified
- A52.11 Tabes dorsalis
- A52.12 Other cerebrospinal syphilis
- A52.13 Late syphilitic meningitis
- A52.14 Late syphilitic encephalitis
- A52.15 Late syphilitic neuropathy
- A52.16 Charcot's arthropathy (tabetic)
- A52.17 General paresis
- A52.19 Other symptomatic neurosyphilis
- A52.2 Asymptomatic neurosyphilis
- A52.3 Neurosyphilis, unspecified
- A52.7 Other symptomatic late syphilisNon-billable
- A52.71 Late syphilitic oculopathy
- A52.72 Syphilis of lung and bronchus
- A52.73 Symptomatic late syphilis of other respiratory organs
- A52.74 Syphilis of liver and other viscera
- A52.75 Syphilis of kidney and ureter
- A52.76 Other genitourinary symptomatic late syphilis
- A52.77 Syphilis of bone and joint
- A52.78 Syphilis of other musculoskeletal tissue
- A52.79 Other symptomatic late syphilis
- A52.8 Late syphilis, latent
- A52.9 Late syphilis, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the A52 range.
Neurosyphilis
Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
Syphilis, Cardiovascular
Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.
Syphilitic Aortic Aneurysm
Aneurysm of the aorta secondary to syphilis.
Syphilitic Aortitis
Aortitis secondary to syphilis.
Syphilitic Endocarditis
Endocarditis secondary to syphilis.
Tabes Dorsalis
Parenchymatous NEUROSYPHILIS marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. The condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, URINARY INCONTINENCE; ATAXIA; severely impaired position and vibratory sense, abnormal gait (see GAIT DISORDERS, NEUROLOGIC), OPTIC ATROPHY; Argyll-Robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (Charcot's Joint; see ARTHROPATHY, NEUROGENIC). (From Adams et al., Principles of Neurology, 6th ed, p726)
Tertiary Syphilis
A stage of syphilis that occurs fifteen to thirty years after the initial infection; it can include gumma formation and cardiovascular or central nervous system involvement (neurosyphilis).
About the A52 Code Range
Late syphilis can involve the heart, blood vessels, nervous system, and other organs. Its subdivisions also distinguish latent and unspecified disease.
A52.0 groups heart and blood vessel involvement, with finer codes for the aorta, heart, and blood vessels in the brain. Syphilis involving the nervous system is called neurosyphilis. A52.1 identifies cases with symptoms, A52.2 identifies cases without symptoms, and A52.3 is unspecified neurosyphilis.
A52.7 separates other symptomatic late syphilis by affected site, including the eyes, lungs, liver, kidneys, bones, and joints. A52.8 is latent late syphilis; A52.9 is unspecified late syphilis.
Questions About This Page
How many billable codes are in the A52 range?
Of the 34 codes in this range, 30 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the A52 range classify?
The range classifies late syphilis. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
