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  6. 2025 ICD-10-CM Code E23.3

2025 ICD-10-CM Diagnosis Code E23.3

Hypothalamic dysfunction, not elsewhere classified

ICD-10-CM Code:
E23.3
ICD-10 Code for:
Hypothalamic dysfunction, not elsewhere classified
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

E23.3 is a billable diagnosis code used to specify a medical diagnosis of hypothalamic dysfunction, not elsewhere classified. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2024 through September 30, 2025.

Code Classification

  • Endocrine, nutritional and metabolic diseases
    E00–E89
    • Disorders of other endocrine glands
      E20-E35
      • Hypofunction and other disorders of the pituitary gland
        E23

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Absent osmoregulation
  • Adipsia
  • Amenorrhea due to hypothalamic disorder
  • Amenorrhea due to pituitary dysfunction
  • Central alveolar hypoventilation syndrome
  • Childhood obesity
  • Chronic hypernatremia
  • Defective osmoregulation
  • Defective osmoregulation
  • Endocrine axis dysfunction
  • Endocrine menstrual disturbance
  • Exercise induced hypothalamic insufficiency
  • Hypernatremia
  • Hypernatremic dehydration
  • Hypoplasia of hypothalamus
  • Hypothalamic adipsic hypernatremia syndrome
  • Hypothalamic amenorrhea
  • Hypothalamic disorder of appetite
  • Hypothalamic overactivity
  • Hypothalamic syndrome
  • Hypothalamic-pituitary-gonadal axis dysfunction
  • Late-onset central hypoventilation co-occurrent and due to hypothalamic dysfunction
  • Loss of hypothalamic inhibition
  • Osmoregulation defect - absent thirst
  • Primary hypothalamic insufficiency
  • Rapid-onset childhood obesity, hypothalamic dysfunction, hypoventilation, autonomic dysregulation syndrome
  • Secondary amenorrhea
  • Secondary hypothalamic insufficiency

Clinical Classification

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

Pituitary disorders

CCSR Code: END013

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Clinical Information

  • Hypernatremia

    excessive amount of sodium in the blood. (dorland, 27th ed)

  • Secondary Amenorrhea

    the cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal.

  • Hypernatremic Dehydration

    dehydration resulting from abnormally high levels of sodium in the blood. infants and individuals that are intubated are at highest risk.

  • Grade 1 Hypernatremia, CTCAE|Grade 1 Hypernatremia

    >uln-150 mmol/l

  • Grade 2 Hypernatremia, CTCAE|Grade 2 Hypernatremia

    >150-155 mmol/l; intervention initiated

  • Grade 3 Hypernatremia, CTCAE|Grade 3 Hypernatremia

    >155-160 mmol/l; hospitalization indicated

  • Grade 4 Hypernatremia, CTCAE|Grade 4 Hypernatremia

    >160 mmol/l; life-threatening consequences

  • Grade 5 Hypernatremia, CTCAE|Grade 5 Hypernatremia

    death

  • Hypernatremia

    higher than normal levels of sodium in the circulating blood.

  • Hypernatremia, CTCAE|Hypernatremia|Hypernatremia

    a disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Prader-Willi syndrome Q87.11
  • Russell-Silver syndrome Q87.19

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert E23.3 to ICD-9-CM

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

Pituitary disorder NOS

ICD-9-CM: 253.9

Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent. The matched code is the closest available option, but it may not fully capture the original diagnosis or clinical intent.

View Conversion

Patient Education


Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.