2026 ICD-10-CM Diagnosis Code Z88.9Allergy status to unspecified drugs, medicaments and biological substances
Z88.9 is a billable ICD-10-CM diagnosis code for allergy status to unspecified drugs, medicaments and biological substances. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for Z88.9.
Present on Admission (POA)Billing
Z88.9 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Allergy to drug
- Atopy
- Cross sensitivity reaction
- H/O: biological substance allergy
- H/O: multiple allergies
- History of anaphylaxis
- History of atopy
- History of drug-induced anaphylaxis
- Hypersensitivity to endogenous antigen
- Hypersensitivity to foreign antigen
- Non-immunoglobulin E-mediated drug sensitivity
- Propensity to adverse reactions to drug
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- History
- personal (of) - See Also: History, family (of);
- allergy (to) - Z88.9
- medicinal agents - Z88.9
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- History
- personal (of)
- allergy (to)
- History
- personal (of)
- allergy (to)
- drugs, medicaments and biological substances
- History
- personal (of)
- allergy (to)
- medicinal agents
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert Z88.9 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About Z88.9Overview
Is Z88.9 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to unspecified drugs, medicaments and biological substances on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Can Z88.9 be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to unspecified drugs, medicaments and biological substances describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is Z88.9 exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to unspecified drugs, medicaments and biological substances on inpatient claims.
What is the ICD-9 equivalent of Z88.9?
Under the General Equivalence Mappings, allergy status to unspecified drugs, medicaments and biological substances converts to ICD-9-CM V14.9 (hx-drug allergy NOS). The mapping is a direct match.
