2027 ICD-10-CM Diagnosis Code Z88Allergy status to drugs, medicaments and biological substances

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z88

ICD-10-CM Z88
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Z88 is a non-billable ICD-10-CM category code for allergy status to drugs, medicaments and biological substances, so it cannot be submitted on claims. Use a more specific code from this category instead, such as Z88.0, Z88.1, Z88.2, and Z88.3.

Code Identity

ICD-10-CM Code
Z88
Billable Status
No — Non-Billable Category
Code Describes
Allergy status to drugs, medicaments and biological substances
Short Description
Allergy status to drug/meds/biol subst
Chapter
Z77-Z99
Persons with potential health hazards related to family and personal history and certain conditions influencing health status

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ88Allergy status to drugs, medicaments and biological substances
This CodeZ88Allergy status to drugs, medicaments and biological substances

Specific Coding for Allergy status to drug/meds/biol substOverview

Non-specific codes like Z88 require more characters. Use one of these billable codes instead:

  • Use Z88.0 for Allergy status to penicillin

  • Use Z88.1 for Allergy status to other antibiotic agents

  • Use Z88.2 for Allergy status to sulfonamides

  • Use Z88.3 for Allergy status to other anti-infective agents

  • Use Z88.4 for Allergy status to anesthetic agent

  • Use Z88.5 for Allergy status to narcotic agent

  • Use Z88.6 for Allergy status to analgesic agent

  • Use Z88.7 for Allergy status to serum and vaccine

  • Use Z88.8 for Allergy status to other drugs, medicaments and biological substances

  • Use Z88.9 for Allergy status to unspecified drugs, medicaments and biological substances

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Z88: its own notes plus those printed at block Z77-Z99 and Chapter 21. A note printed at a category, block or chapter applies to every code under it.

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

  • Allergy status, other than to drugs and biological substances (Z91.0-)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

From Block Z77-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status applies to 567 codes
  • any follow-up examination (Z08-Z09)

Notes

General instructions on how these codes are used.

From Chapter 21 (Z00-Z99) Factors influencing health status and contact with health services applies to 1,425 codes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Z88, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming Z88: its condition is not part of those codes, and both may be reported when the patient has both.

  • Z91.0 Allergy status, other than to drugs and biological substances
    Allergy status to drugs, medicaments, and biological substances (Z88.-)

Code Also 1

These codes say Z88 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • Z87.892 Personal history of anaphylaxis
    allergy status to drugs, medicaments and biological substances (Z88.-)

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Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Z88Overview

What is the ICD-10 code for allergy status to drugs, medicaments and biological substances?

Z88 is the ICD-10-CM category for allergy status to drugs, medicaments and biological substances, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is Z88 a billable code?

No. This is a category header that groups the codes for allergy status to drugs, medicaments and biological substances, and headers cannot be submitted on claims. Claims for allergy status to drugs, medicaments and biological substances need a more specific code from this category, such as Z88.0, Z88.1, and Z88.2.