ICD-10-CM Code Z88.3

Allergy status to other anti-infective agents status

Version 2020 Billable Code Unacceptable Principal Diagnosis POA Exempt

Valid for Submission

Z88.3 is a billable code used to specify a medical diagnosis of allergy status to other anti-infective agents status. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code Z88.3 might also be used to specify conditions or terms like allergy to 4-quinolones, allergy to abacavir, allergy to acetic acid, allergy to acridine derivative azo, allergy to acyclovir, allergy to adhesive agent, etc The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

The code Z88.3 describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

Short Description:Allergy status to other anti-infective agents status
Long Description:Allergy status to other anti-infective agents status

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code Z88.3 are found in the index:

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10 Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual’s health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Allergy to 4-quinolones
  • Allergy to abacavir
  • Allergy to acetic acid
  • Allergy to acridine derivative azo
  • Allergy to acyclovir
  • Allergy to adhesive agent
  • Allergy to albendazole
  • Allergy to aldehyde
  • Allergy to aldehyde
  • Allergy to aldehyde
  • Allergy to amantadine
  • Allergy to amidine disinfectant
  • Allergy to aminoquinoline antimalarial agent
  • Allergy to amodiaquine
  • Allergy to amorolfine
  • Allergy to amphotericin
  • Allergy to anthelmintic agent
  • Allergy to antibacterial drug
  • Allergy to antifungal agent
  • Allergy to antileprotic drug
  • Allergy to antimalarial agent
  • Allergy to antimony antiprotozoal
  • Allergy to antiprotozoal
  • Allergy to antiretroviral drug
  • Allergy to antituberculosis agent
  • Allergy to antiviral agent
  • Allergy to atovaquone
  • Allergy to azole antifungal agent
  • Allergy to benzimidazole anthelmintic
  • Allergy to benzoyl peroxide
  • Allergy to benzyl benzoate
  • Allergy to bephenium
  • Allergy to biguanide
  • Allergy to biguanide
  • Allergy to biguanide antimalarial agent
  • Allergy to biguanide disinfectant
  • Allergy to biocide
  • Allergy to biocide
  • Allergy to biocide
  • Allergy to bismuth subnitrate and iodoform paste impregnated gauze
  • Allergy to borate
  • Allergy to boric acid
  • Allergy to brilliant green
  • Allergy to cetrimide
  • Allergy to cetylpyridinium
  • Allergy to chlorhexidine
  • Allergy to chlorhexidine hydrochloride and neomycin sulfate
  • Allergy to chloroquine
  • Allergy to chloroxylenol
  • Allergy to Cinchona antimalarial
  • Allergy to clioquinol
  • Allergy to clotrimazole
  • Allergy to dapsone
  • Allergy to darunavir
  • Allergy to dequalinium
  • Allergy to diamidine antiprotozoal
  • Allergy to dichloroacetamide antiprotozoal
  • Allergy to didanosine
  • Allergy to diethylcarbamazine
  • Allergy to diloxanide
  • Allergy to domiphen
  • Allergy to econazole
  • Allergy to emollient
  • Allergy to ethanol
  • Allergy to famciclovir
  • Allergy to fenticonazole
  • Allergy to fluconazole
  • Allergy to flucytosine
  • Allergy to formaldehyde
  • Allergy to foscarnet
  • Allergy to ganciclovir
  • Allergy to gentian violet
  • Allergy to glutaraldehyde
  • Allergy to griseofulvin
  • Allergy to halofantrine
  • Allergy to hexachlorophene
  • Allergy to hexetidine
  • Allergy to hydrargaphen
  • Allergy to hydrogen peroxide
  • Allergy to hydroxychloroquine
  • Allergy to hydroxyquinoline antiprotozoal
  • Allergy to ichthammol
  • Allergy to idoxuridine
  • Allergy to imidazole antifungal agent
  • Allergy to industrial methylated spirit
  • Allergy to inosine pranobex
  • Allergy to interferon
  • Allergy to interferon alfa-2a
  • Allergy to interferon alfa-2b
  • Allergy to interferon alfa-n1
  • Allergy to interferon gamma-1b
  • Allergy to iodine compound
  • Allergy to iodine compound
  • Allergy to iodophore
  • Allergy to isoconazole
  • Allergy to itraconazole
  • Allergy to ketoconazole
  • Allergy to mebendazole
  • Allergy to mefloquine
  • Allergy to methenamine hippurate
  • Allergy to metronidazole
  • Allergy to miconazole
  • Allergy to monosulfiram
  • Allergy to nalidixic acid
  • Allergy to natamycin
  • Allergy to neomycin
  • Allergy to nevirapine
  • Allergy to niclosamide
  • Allergy to nimorazole
  • Allergy to nitrofurantoin
  • Allergy to nitroimidazole
  • Allergy to nitrophenol
  • Allergy to noxythiolin
  • Allergy to nystatin
  • Allergy to pentamidine
  • Allergy to phenol
  • Allergy to piperazine
  • Allergy to polynoxylin
  • Allergy to potassium permanganate
  • Allergy to povidone iodine
  • Allergy to primaquine
  • Allergy to proguanil
  • Allergy to protease inhibitor
  • Allergy to pyrantel
  • Allergy to pyrimethamine
  • Allergy to quaternary ammonium surfactant
  • Allergy to quaternary pyridinium surfactant
  • Allergy to quaternary quinolinium surfactant
  • Allergy to quinacrine
  • Allergy to quinine
  • Allergy to reverse transcriptase inhibitor
  • Allergy to ribavirin
  • Allergy to rubber
  • Allergy to silver nitrate
  • Allergy to sodium perborate
  • Allergy to sodium stibogluconate
  • Allergy to sulconazole
  • Allergy to terbinafine
  • Allergy to thiabendazole
  • Allergy to tinidazole
  • Allergy to tioconazole
  • Allergy to tolnaftate
  • Allergy to triazole antifungal agent
  • Allergy to triclosan
  • Allergy to trifluridine
  • Allergy to trimethoprim
  • Allergy to undecenoate
  • Allergy to valacyclovir
  • Allergy to vidarabine
  • Allergy to zalcitabine
  • Allergy to zidovudine
  • Nalidixic acid sensitivity

Present on Admission (POA)

Z88.3 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here .

CMS POA Indicator Options and Definitions
POA Indicator CodePOA Reason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert Z88.3 to ICD-9

  • V14.3 - Hx-anti-infect allergy

Code Classification

  • Factors influencing health status and contact with health services (Z00–Z99)
    • Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99)
      • Allergy status to drug/meds/biol subst (Z88)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

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