ICD-10-CM Code Z88.0

Allergy status to penicillin

Version 2020 Billable Code Unacceptable Principal Diagnosis POA Exempt

Valid for Submission

Z88.0 is a billable code used to specify a medical diagnosis of allergy status to penicillin. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code Z88.0 might also be used to specify conditions or terms like allergy to amdinocillin, allergy to amdinocillin pivoxil, allergy to amoxicillin, allergy to ampicillin, allergy to ampicillin and cloxacillin, allergy to ampicillin and flucloxacillin, etc The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

The code Z88.0 describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

Short Description:Allergy status to penicillin
Long Description:Allergy status to penicillin

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code Z88.0 are found in the index:

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10 Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual’s health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Allergy to amdinocillin
  • Allergy to amdinocillin pivoxil
  • Allergy to amoxicillin
  • Allergy to ampicillin
  • Allergy to ampicillin and cloxacillin
  • Allergy to ampicillin and flucloxacillin
  • Allergy to antipseudomonal penicillin
  • Allergy to azlocillin
  • Allergy to bacampicillin
  • Allergy to benethamine penicillin
  • Allergy to broad spectrum penicillin
  • Allergy to carbenicillin
  • Allergy to carfecillin
  • Allergy to cloxacillin
  • Allergy to cyclacillin
  • Allergy to floxacillin
  • Allergy to methicillin
  • Allergy to mezlocillin
  • Allergy to penicillin
  • Allergy to penicillin G
  • Allergy to penicillin V
  • Allergy to penicillinase-resistant penicillin
  • Allergy to penicillinase-sensitive penicillin
  • Allergy to phenethicillin
  • Allergy to piperacillin
  • Allergy to piperacillin and tazobactam
  • Allergy to pivampicillin
  • Allergy to pivampicillin and pivmecillinam
  • Allergy to talampicillin
  • Allergy to temocillin
  • Allergy to ticarcillin
  • Allergy to ticarcillin and clavulanic acid

Present on Admission (POA)

Z88.0 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here .

CMS POA Indicator Options and Definitions
POA Indicator CodePOA Reason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert Z88.0 to ICD-9

  • V14.0 - Hx-penicillin allergy

Code Classification

  • Factors influencing health status and contact with health services (Z00–Z99)
    • Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99)
      • Allergy status to drug/meds/biol subst (Z88)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Antibiotics are powerful medicines that fight bacterial infections. Used properly, antibiotics can save lives. They either kill bacteria or keep them from reproducing. Your body's natural defenses can usually take it from there.

Antibiotics do not fight infections caused by viruses, such as

  • Colds
  • Flu
  • Most coughs and bronchitis
  • Sore throats, unless caused by strep

If a virus is making you sick, taking antibiotics may do more harm than good. Using antibiotics when you don't need them, or not using them properly, can add to antibiotic resistance. This happens when bacteria change and become able to resist the effects of an antibiotic.

When you take antibiotics, follow the directions carefully. It is important to finish your medicine even if you feel better. If you stop treatment too soon, some bacteria may survive and re-infect you. Do not save antibiotics for later or use someone else's prescription.

Centers for Disease Control and Prevention

[Learn More]

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

[Learn More]