2027 ICD-10-CM Diagnosis Code Z88.6Allergy status to analgesic agent
Z88.6 is a billable ICD-10-CM diagnosis code for allergy status to analgesic agent. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for Z88.6.
Present on Admission (POA)Billing
Z88.6 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99).
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Allergy to acemetacin
- Allergy to acetaminophen
- Allergy to acetaminophen and/or dextropropoxyphene
- Allergy to alfentanil
- Allergy to apazone
- Allergy to buprenorphine
- Allergy to codeine
- Allergy to dextromoramide
- Allergy to diamorphine
- Allergy to diclofenac
- Allergy to dihydrocodeine
- Allergy to dipipanone
- Allergy to etodolac
- Allergy to felbinac
- Allergy to fenbufen
- Allergy to fentanyl
- Allergy to flurbiprofen
- Allergy to ibuprofen
- Allergy to indomethacin
- Allergy to ketoprofen
- Allergy to ketorolac
- Allergy to levorphanol
- Allergy to mefenamic acid
- Allergy to meperidine
- Allergy to meptazinol
- Allergy to metamizole
- Allergy to methadone
- Allergy to methotrimeprazine
- Allergy to morphinan opioid
- Allergy to morphine
- Allergy to nabumetone
- Allergy to nalbuphine
- Allergy to naproxen
- Allergy to nefopam
- Allergy to non-steroidal anti-inflammatory agent
- Allergy to noscapine
- Allergy to opium alkaloid
- Allergy to oxyphenbutazone
- Allergy to pentazocine
- Allergy to pethidine analog
- Allergy to phenazocine
- Allergy to phenoperidine
- Allergy to phenylbutazone
- Allergy to pholcodine
- Allergy to piroxicam
- Allergy to propoxyphene
- Allergy to remifentanil
- Allergy to salicylate
- Allergy to sufentanil
- Allergy to sulindac
- Allergy to tenoxicam
- Allergy to tiaprofenic acid
- Allergy to tolmetin
- Allergy to tramadol
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to Z88.6: its own notes plus those printed at Z88, block Z77-Z99, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code Also
A second code may be needed to fully describe the condition; the note gives no sequencing direction.
Notes
General instructions on how these codes are used.
- Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
- (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
- (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name Z88.6, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming Z88.6: its condition is not part of those codes, and both may be reported when the patient has both.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
personal (of) See Also: History, family (of);
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert Z88.6 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About Z88.6Overview
What is the ICD-10 code for allergy status to analgesic agent?
The ICD-10-CM code for allergy status to analgesic agent is Z88.6 (sometimes written as Z886). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is Z88.6 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to analgesic agent on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does Z88.6 group to?
On inpatient claims, allergy status to analgesic agent maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.
Can Z88.6 be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to analgesic agent describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is Z88.6 exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to analgesic agent on inpatient claims. The code appears in the Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99) range of the CMS exempt list.
