2026 ICD-10-CM Diagnosis Code Z88.6Allergy status to analgesic agent

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z88

ICD-10-CM Z88.6
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z88.6 is a billable ICD-10-CM diagnosis code for allergy status to analgesic agent. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.

Code Identity

ICD-10-CM Code
Z88.6
Billable Status
Yes — Valid for Submission
Code Describes
Allergy status to analgesic agent
Short Description
Allergy status to analgesic agent
Same as the full description in the CMS dataset.
Parent Code
Z88
Allergy status to drugs, medicaments and biological substances

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ88Allergy status to drugs, medicaments and biological substances
This CodeZ88.6Allergy status to analgesic agent

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z88.6.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z88.6 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Allergy to acemetacin
  • Allergy to acetaminophen
  • Allergy to acetaminophen and/or dextropropoxyphene
  • Allergy to alfentanil
  • Allergy to apazone
  • Allergy to buprenorphine
  • Allergy to codeine
  • Allergy to dextromoramide
  • Allergy to diamorphine
  • Allergy to diclofenac
  • Allergy to dihydrocodeine
  • Allergy to dipipanone
  • Allergy to etodolac
  • Allergy to felbinac
  • Allergy to fenbufen
  • Allergy to fentanyl
  • Allergy to flurbiprofen
  • Allergy to ibuprofen
  • Allergy to indomethacin
  • Allergy to ketoprofen
  • Allergy to ketorolac
  • Allergy to levorphanol
  • Allergy to mefenamic acid
  • Allergy to meperidine
  • Allergy to meptazinol
  • Allergy to metamizole
  • Allergy to methadone
  • Allergy to methotrimeprazine
  • Allergy to morphinan opioid
  • Allergy to morphine
  • Allergy to nabumetone
  • Allergy to nalbuphine
  • Allergy to naproxen
  • Allergy to nefopam
  • Allergy to non-steroidal anti-inflammatory agent
  • Allergy to noscapine
  • Allergy to opium alkaloid
  • Allergy to oxyphenbutazone
  • Allergy to pentazocine
  • Allergy to pethidine analog
  • Allergy to phenazocine
  • Allergy to phenoperidine
  • Allergy to phenylbutazone
  • Allergy to pholcodine
  • Allergy to piroxicam
  • Allergy to propoxyphene
  • Allergy to remifentanil
  • Allergy to salicylate
  • Allergy to sufentanil
  • Allergy to sulindac
  • Allergy to tenoxicam
  • Allergy to tiaprofenic acid
  • Allergy to tolmetin
  • Allergy to tramadol

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • History
      • personal (of)
        • allergy (to)
          • analgesic agent NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC025
Other specified status
Default principal diagnosis: inpatient No · outpatient Yes

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z88.6 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V14.6 Hx-analgesic allergy
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2020No changes
FY 2021RevisedCode revised
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z88.6Overview

Is Z88.6 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to analgesic agent on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z88.6 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to analgesic agent describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z88.6 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to analgesic agent on inpatient claims.

What is the ICD-9 equivalent of Z88.6?

Under the General Equivalence Mappings, allergy status to analgesic agent converts to ICD-9-CM V14.6 (hx-analgesic allergy). The mapping is a direct match.