2026 ICD-10-CM Diagnosis Code Z88.4Allergy status to anesthetic agent

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z88

ICD-10-CM Z88.4
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z88.4 is a billable ICD-10-CM diagnosis code for allergy status to anesthetic agent. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.

Code Identity

ICD-10-CM Code
Z88.4
Billable Status
Yes — Valid for Submission
Code Describes
Allergy status to anesthetic agent
Short Description
Allergy status to anesthetic agent
Same as the full description in the CMS dataset.
Parent Code
Z88
Allergy status to drugs, medicaments and biological substances

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ88Allergy status to drugs, medicaments and biological substances
This CodeZ88.4Allergy status to anesthetic agent

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z88.4.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z88.4 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Allergy to barbiturate
  • Allergy to benoxinate
  • Allergy to benzocaine
  • Allergy to bupivacaine
  • Allergy to chloroprocaine
  • Allergy to cocaine
  • Allergy to desflurane
  • Allergy to dibucaine
  • Allergy to diethyl ether
  • Allergy to enflurane
  • Allergy to etomidate
  • Allergy to halothane
  • Allergy to isoflurane
  • Allergy to ketamine
  • Allergy to lidocaine
  • Allergy to local anesthetic
  • Allergy to methohexital
  • Allergy to midazolam
  • Allergy to prilocaine
  • Allergy to procaine
  • Allergy to propofol
  • Allergy to proxymetacaine
  • Allergy to sevoflurane
  • Allergy to substance with ether structure
  • Allergy to tetracaine
  • Allergy to thiopental
  • History of anesthesia problem
  • History of severe nausea and vomiting following administration of anesthetic agent

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • History
      • personal (of)
        • allergy (to)
          • anesthetic
    • History
      • personal (of)
        • hyperthermia, malignant

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC025
Other specified status
Default principal diagnosis: inpatient No · outpatient Yes

Patient EducationClinical

Anesthesia

Anesthesia is the use of medicines, called anesthetics, to prevent pain during surgery and other medical procedures. Medicine may be given by injection, inhalation, topical lotion, spray, eye drops, or a skin patch.

The full article covers:

  • What is anesthesia?
  • What is anesthesia used for?
  • What are the types of anesthesia?
  • What are the risks of anesthesia?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z88.4 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V14.4 Hx-anesthetic allergy
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2020No changes
FY 2021RevisedCode revised
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z88.4Overview

Is Z88.4 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to anesthetic agent on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z88.4 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to anesthetic agent describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z88.4 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to anesthetic agent on inpatient claims.

What is the ICD-9 equivalent of Z88.4?

Under the General Equivalence Mappings, allergy status to anesthetic agent converts to ICD-9-CM V14.4 (hx-anesthetic allergy). The mapping is a direct match.