2027 ICD-10-CM Diagnosis Code Z88.1Allergy status to other antibiotic agents
Z88.1 is a billable ICD-10-CM diagnosis code for allergy status to other antibiotic agents. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for Z88.1.
Present on Admission (POA)Billing
Z88.1 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99).
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Allergy to aclarubicin
- Allergy to amikacin
- Allergy to aminoglycoside
- Allergy to amoxicillin and/or clavulanic acid
- Allergy to azithromycin
- Allergy to aztreonam
- Allergy to bleomycin
- Allergy to capreomycin
- Allergy to carbamate
- Allergy to carbapenem
- Allergy to cefaclor
- Allergy to cefadroxil
- Allergy to cefamandole
- Allergy to cefazolin
- Allergy to cefixime
- Allergy to cefodizime
- Allergy to cefotaxime
- Allergy to cefoxitin
- Allergy to cefpirome
- Allergy to cefpodoxime
- Allergy to cefsulodin
- Allergy to ceftazidime
- Allergy to ceftibuten
- Allergy to ceftizoxime
- Allergy to ceftriaxone
- Allergy to cefuroxime
- Allergy to cephalexin
- Allergy to cephalosporin
- Allergy to cephalothin
- Allergy to cephamycin
- Allergy to cephradine
- Allergy to chloramphenicol
- Allergy to chlorhexidine and/or neomycin
- Allergy to chlortetracycline
- Allergy to cinoxacin
- Allergy to ciprofloxacin
- Allergy to clarithromycin
- Allergy to clavulanic acid and/or ticarcillin
- Allergy to clindamycin
- Allergy to clofazimine
- Allergy to clomocycline
- Allergy to colistin
- Allergy to cycloserine
- Allergy to dactinomycin
- Allergy to demeclocycline
- Allergy to doxorubicin
- Allergy to doxycycline
- Allergy to enoxacin
- Allergy to epirubicin
- Allergy to ertapenem
- Allergy to erythromycin
- Allergy to ethambutol
- Allergy to fluoroquinolone
- Allergy to fosfomycin
- Allergy to framycetin
- Allergy to fusidic acid
- Allergy to gentamicin
- Allergy to idarubicin
- Allergy to imipenem
- Allergy to isoniazid
- Allergy to kanamycin
- Allergy to levofloxacin
- Allergy to lincomycin
- Allergy to lymecycline
- Allergy to macrolide
- Allergy to mandelic acid
- Allergy to meropenem
- Allergy to methenamine
- Allergy to minocycline
- Allergy to mitomycin
- Allergy to mitoxantrone
- Allergy to monobactam
- Allergy to moxalactam
- Allergy to mupirocin
- Allergy to neomycin
- Allergy to netilmicin
- Allergy to nitrofurazone
- Allergy to norfloxacin
- Allergy to ofloxacin
- Allergy to oxytetracycline
- Allergy to piperacillin and/or tazobactam
- Allergy to plicamycin
- Allergy to polymyxin
- Allergy to polymyxin B
- Allergy to pyrazinamide
- Allergy to rifabutin
- Allergy to rifampin
- Allergy to rosoxacin
- Allergy to rubber
- Allergy to spectinomycin
- Allergy to streptomycin
- Allergy to sulfamethoxazole and/or trimethoprim
- Allergy to teicoplanin
- Allergy to temafloxacin
- Allergy to tetracycline
- Allergy to tobramycin
- Allergy to vancomycin
- Hypersensitivity to erythromycin
- Hypersensitivity to gentamicin
- Hypersensitivity to minocycline
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to Z88.1: its own notes plus those printed at Z88, block Z77-Z99, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code Also
A second code may be needed to fully describe the condition; the note gives no sequencing direction.
Notes
General instructions on how these codes are used.
- Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
- (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
- (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name Z88.1, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming Z88.1: its condition is not part of those codes, and both may be reported when the patient has both.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
personal (of) See Also: History, family (of);
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Antibiotics
Antibiotics are medicines that fight bacterial infections in people and animals. They work by killing the bacteria or by making it hard for the bacteria to grow and multiply.
The full article covers:
- What are antibiotics?
- What do antibiotics treat?
- Do antibiotics treat viral infections?
- What are the side effects of antibiotics?
- Why is it important to take antibiotics only when they're needed?
- How do I use antibiotics correctly?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert Z88.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About Z88.1Overview
What is the ICD-10 code for allergy status to other antibiotic agents?
The ICD-10-CM code for allergy status to other antibiotic agents is Z88.1 (sometimes written as Z881). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is Z88.1 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to other antibiotic agents on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does Z88.1 group to?
On inpatient claims, allergy status to other antibiotic agents maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.
Can Z88.1 be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to other antibiotic agents describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is Z88.1 exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to other antibiotic agents on inpatient claims. The code appears in the Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99) range of the CMS exempt list.
