2026 ICD-10-CM Diagnosis Code Z88.0Allergy status to penicillin

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z88

ICD-10-CM Z88.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z88.0 is a billable ICD-10-CM diagnosis code for allergy status to penicillin. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.

Code Identity

ICD-10-CM Code
Z88.0
Billable Status
Yes — Valid for Submission
Code Describes
Allergy status to penicillin
Short Description
Allergy status to penicillin
Same as the full description in the CMS dataset.
Parent Code
Z88
Allergy status to drugs, medicaments and biological substances

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ88Allergy status to drugs, medicaments and biological substances
This CodeZ88.0Allergy status to penicillin

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z88.0.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z88.0 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Allergy to amdinocillin
  • Allergy to amdinocillin pivoxil
  • Allergy to amoxicillin
  • Allergy to amoxicillin and/or clavulanic acid
  • Allergy to ampicillin
  • Allergy to ampicillin and/or cloxacillin
  • Allergy to ampicillin and/or floxacillin
  • Allergy to azlocillin
  • Allergy to bacampicillin
  • Allergy to benethamine penicillin
  • Allergy to carbenicillin
  • Allergy to carfecillin
  • Allergy to clavulanic acid and/or ticarcillin
  • Allergy to cloxacillin
  • Allergy to cyclacillin
  • Allergy to floxacillin
  • Allergy to methicillin
  • Allergy to mezlocillin
  • Allergy to penicillin
  • Allergy to penicillin G
  • Allergy to penicillin V
  • Allergy to phenethicillin
  • Allergy to piperacillin
  • Allergy to piperacillin and/or tazobactam
  • Allergy to pivampicillin
  • Allergy to pivampicillin and/or pivmecillinam
  • Allergy to talampicillin
  • Allergy to temocillin
  • Allergy to ticarcillin

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • History
      • personal (of)
        • allergy (to)
          • penicillin

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC025
Other specified status
Default principal diagnosis: inpatient No · outpatient Yes

Patient EducationClinical

Antibiotics

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The full article covers:

  • What are antibiotics?
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  • Do antibiotics treat viral infections?
  • What are the side effects of antibiotics?
  • Why is it important to take antibiotics only when they're needed?
  • How do I use antibiotics correctly?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z88.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V14.0 Hx-penicillin allergy
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z88.0Overview

Is Z88.0 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to penicillin on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z88.0 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to penicillin describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z88.0 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to penicillin on inpatient claims.

What is the ICD-9 equivalent of Z88.0?

Under the General Equivalence Mappings, allergy status to penicillin converts to ICD-9-CM V14.0 (hx-penicillin allergy). The mapping is a direct match.