2027 ICD-10-CM Diagnosis Code T50.Z16AUnderdosing of immunoglobulin, initial encounter
T50.Z16A is a billable ICD-10-CM diagnosis code for underdosing of immunoglobulin, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Underdosing of drugs and medicaments, initial encounter.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T50.Z16A.
Coding GuidelinesGuidance
Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to T50.Z16A: its own notes plus those printed at T50, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify any retained foreign body, if applicable (Z18.-)
Notes
General instructions on how these codes are used.
- Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
- The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.
7th Character
Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.
- The appropriate 7th character is to be added to each code from category T50
- Ainitial encounter this code
- Dsubsequent encounter
- Ssequela
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name T50.Z16A, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming T50.Z16A: its condition is not part of those codes, and both may be reported when the patient has both.
Use Additional Code 3
These codes say to use an additional code from the note, and T50.Z16A is one of the codes named.
- G04.02 Postimmunization acute disseminated encephalitis, myelitis and encephalomyelitiscode to identify the vaccine (T50.A-, T50.B-, T50.Z-) names T50.Z-, which includes this code
- G04.32 Postimmunization acute necrotizing hemorrhagic encephalopathycode to identify the vaccine (T50.A-, T50.B-, T50.Z-) names T50.Z-, which includes this code
- G61.1 Serum neuropathycode for adverse effect, if applicable, to identify serum (T50.-) names T50.-, which includes this code
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Antitoxins
antisera from immunized animals that is purified and used as a passive immunizing agent against specific bacterial toxins.gamma-Globulins
serum globulins that migrate to the gamma region (most positively charged) upon electrophoresis. at one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. but since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.Rho(D) Immune Globulin
immunizing agent containing immunoglobulin g anti-rho(d) used for preventing rh immunization in rh-negative individuals exposed to rh-positive red blood cells.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Medication Errors
Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T50.Z16A to ICD-9-CMHistory
Code HistoryHistory
Questions About T50.Z16AOverview
What is the ICD-10 code for underdosing of immunoglobulin, initial encounter?
The ICD-10-CM code for underdosing of immunoglobulin, initial encounter is T50.Z16A (sometimes written as T50Z16A). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is T50.Z16A (Underdosing of immunoglobulin) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report underdosing of immunoglobulin, initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What does the 7th character A in T50.Z16A mean?
The final character A marks the initial encounter: use it while the patient is receiving active treatment for underdosing of immunoglobulin, such as an emergency visit or first evaluation.
What MS-DRG does T50.Z16A group to?
On inpatient claims, underdosing of immunoglobulin, initial encounter maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.
Can T50.Z16A be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because underdosing of immunoglobulin, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
