2027 ICD-10-CM Diagnosis Code T50.905AAdverse effect of unspecified drugs, medicaments and biological substances, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T50

ICD-10-CM T50.905A
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T50.905A is a billable ICD-10-CM diagnosis code for adverse effect of unspecified drugs, medicaments and biological substances, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 917 through 918. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code
T50.905A
Billable Status
Yes — Valid for Submission
Code Describes
Adverse effect of unspecified drugs, medicaments and biological substances, initial encounter
Short Description
Adverse effect of unsp drug/meds/biol subst, init
Parent Code
Adverse effect of unspecified drugs, medicaments and biological substances

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT50Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances
This CodeT50.905AAdverse effect of unspecified drugs, medicaments and biological substances, initial encounter

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal drug tolerance
  • Abnormal hormone secretion
  • Abnormal movement
  • Abnormality of secretion of gastrin
  • Acanthosis nigricans
  • Acneiform drug eruption
  • Acneiform eruption
  • Acquired acanthosis nigricans
  • Acquired central hypothyroidism
  • Acquired coagulation factor inhibitor disorder
  • Acquired epidermolysis bullosa
  • Acquired long QT syndrome
  • Acquired thrombotic thrombocytopenic purpura
  • Acute akathisia caused by drug
  • Acute angle closure of left eye caused by drug
  • Acute angle closure of right eye caused by drug
  • Acute drug-induced gout
  • Acute drug-induced interstitial lung disorder
  • Acute drug-induced tubulointerstitial nephritis
  • Acute drug-induced ulcer of stomach
  • Acute dystonia caused by antipsychotic medication
  • Acute edema
  • Acute eosinophilic pneumonia caused by medication
  • Acute febrile neutrophilic dermatosis
  • Acute gastric erosion associated with drug ingestion
  • Acute gout
  • Acute hepatic failure
  • Acute hepatic failure due to drugs
  • Acute pulmonary edema
  • Acute toxic cicatrizing conjunctivitis
  • Acute toxic conjunctivitis
  • Acute tubulointerstitial nephritis
  • Adverse cutaneous reaction to volatile oil
  • Adverse drug interaction
  • Adverse drug interaction with dietary supplement
  • Adverse drug interaction with herbal supplement
  • Adverse drug interaction with over-the-counter medication
  • Adverse drug interaction with prescription medication
  • Adverse drug interaction with tobacco
  • Adverse medication interaction with medication
  • Adverse reaction caused by drug following provocation test
  • Adverse reaction following injection of substance
  • Adverse reaction to biological substance
  • Adverse reaction to drug
  • Adverse reaction to lipotropic drugs
  • Adverse reaction to oil
  • Adverse reaction to pharmaceutical excipient
  • Adverse reaction to substance applied to neonatal skin
  • Akathisia
  • Akathisia caused by drug
  • Allergic contact dermatitis caused by drug in contact with skin
  • Allergic disorder monitoring status
  • Allergic hepatitis
  • Allergic reaction after allergen immunotherapy
  • Allergic reaction due to allergy skin test
  • Allergic reaction to colophony
  • Allergic reaction to drug
  • Allergic sensitization
  • Allergic sensitization by patch test
  • Allergy drug side effect
  • Alopecia due to disturbance of hair cycle
  • Alveolar macrophage pneumonia
  • Alveolar macrophage pneumonia caused by medication
  • Anagen effluvium
  • Anagen effluvium caused by drug
  • Anaphylaxis after allergen immunotherapy
  • Anastomotic ulcer of stomach caused by drug
  • Androgen excess caused by drug
  • Androgen level above reference range
  • Anemia caused by medication
  • Anetoderma
  • Angle closure of left eye caused by drug
  • Angle closure of right eye caused by drug
  • Annular erythema
  • Annular erythema caused by drug
  • Aplasia cutis congenita due to teratogenic drug
  • Aseptic meningitis caused by drug
  • Aseptic peritonitis
  • Atrophy of skin caused by drug
  • Atypical fracture of femur
  • Autoimmune bullous dermatosis due to drug
  • Autonomic neuropathy due to diabetes mellitus
  • Autonomic neuropathy due to drug induced diabetes mellitus
  • Autonomic neuropathy due to medication induced hypoglycemia
  • Azoospermia caused by drug
  • B cell lymphocyte aplasia caused by drug
  • B-cell pseudolymphoma caused by drug
  • Benign intracranial hypertension
  • Benign intracranial hypertension due to drug
  • Benign mucous membrane pemphigoid
  • Benign mucous membrane pemphigoid with ocular involvement
  • Bilateral acute angle closure
  • Bilateral acute angle closure caused by drug
  • Bilateral angle closure caused by drug
  • Bilateral cataract of eyes caused by drug
  • Bilateral drug-induced ocular hypertension
  • Bilateral keratopathy caused by drug
  • Bilateral osteonecrosis of femurs caused by drug
  • Bilateral secondary angle closure glaucoma
  • Blistering of skin due to drug-induced coma
  • Blood disorder monitoring status
  • Blood drug side effect
  • Bronchiolocentric interstitial pneumonia
  • Bronchiolocentric interstitial pneumonia caused by medication
  • Bronchospasm
  • Bronchospasm caused by drug
  • Bullae and sweat gland necrosis in drug-induced coma
  • Bullous dermatosis precipitated by drug treatment
  • Bullous pemphigoid
  • Capillaritis caused by drug
  • Cardiomyopathy caused by drug
  • Cataract due to diabetes mellitus
  • Cataract due to drug induced diabetes mellitus
  • Cataract of left eye caused by medication
  • Cataract of right eye caused by medication
  • Central hypothyroidism
  • Central nervous system depression
  • Cheilitis medicamentosa
  • Chemical peritonitis
  • Chloramphenicol adverse reaction
  • Cholangiohepatitis
  • Cholestatic hepatitis
  • Cholestatic jaundice caused by drug
  • Cholestatic jaundice syndrome
  • Chorea due to tardive dyskinesia
  • Chronic bilateral vestibulopathy caused by ototoxic agent
  • Chronic cicatrizing conjunctivitis caused by drug
  • Chronic disease - drug side effects
  • Chronic drug-induced interstitial lung disorders
  • Chronic drug-induced renal disease
  • Chronic drug-induced tubulointerstitial nephritis
  • Chronic drug-induced ulcer of stomach
  • Chronic eosinophilic pneumonia caused by medication
  • Chronic follicular conjunctivitis caused by drug
  • Chronic gout caused by drug
  • Chronic gout of ankle and/or foot without tophus caused by drug
  • Chronic gout of elbow without tophus caused by drug
  • Chronic gout of hand without tophus caused by drug
  • Chronic gout of hip without tophus caused by drug
  • Chronic gout of knee without tophus caused by drug
  • Chronic gout of multiple sites without tophus caused by drug
  • Chronic gout of shoulder without tophus caused by drug
  • Chronic gout of vertebra without tophus caused by drug
  • Chronic gout of wrist without tophus caused by drug
  • Chronic gout without tophus caused by drug
  • Chronic gouty arthritis
  • Chronic kidney disease stage 1 due to drug induced diabetes mellitus
  • Chronic kidney disease stage 2 due to drug induced diabetes mellitus
  • Chronic kidney disease stage 3 due to drug induced diabetes mellitus
  • Chronic kidney disease stage 4 due to drug induced diabetes mellitus
  • Chronic kidney disease stage 5 due to drug induced diabetes mellitus
  • Chronic tophaceous gout caused by drug
  • Chronic tophaceous gout of ankle and/or foot caused by drug
  • Chronic tophaceous gout of elbow caused by drug
  • Chronic tophaceous gout of hand
  • Chronic tophaceous gout of hand caused by drug
  • Chronic tophaceous gout of hip caused by drug
  • Chronic tophaceous gout of knee caused by drug
  • Chronic tophaceous gout of multiple sites caused by drug
  • Chronic tophaceous gout of shoulder caused by drug
  • Chronic tophaceous gout of vertebra caused by drug
  • Chronic tophaceous gout of wrist caused by drug
  • Chronic toxic cicatrizing conjunctivitis
  • Chronic toxic interstitial nephritis
  • Cicatrizing conjunctivitis
  • Coital disorder
  • Color changes during tooth formation
  • Conjugated hyperbilirubinemia
  • Conjunctival adrenochrome deposits
  • Conjunctival deposit caused by drug
  • Conjunctivitis caused by drug
  • Constricted pupil
  • Contact dermatitis caused by medication
  • Cutaneous B-cell pseudolymphoma
  • Cutaneous inflammation due to cytotoxic therapy
  • Cutaneous T-cell pseudolymphoma
  • Cutaneous ulceration due to cytotoxic therapy
  • Cytopenia caused by drug
  • Dermatosis due to cytotoxic therapy
  • Diabetes mellitus induced by non-steroid drugs
  • Diarrhea caused by drug
  • Diffuse alopecia
  • Dilated cardiomyopathy caused by drug
  • Disorder of autonomic nervous system caused by drug
  • Disorder of ejaculation
  • Disorder of kidney due to drug induced diabetes mellitus
  • Disorder of nail color
  • Disorder of vision due to secondary diabetes mellitus
  • Disturbance of salivary secretion
  • Dizziness caused by drug
  • Dose-related drug-induced neutropenia
  • Drug exanthem
  • Drug induced acquired central hypothyroidism
  • Drug induced anal ulceration
  • Drug induced central sleep apnea
  • Drug induced dysfunction of vestibular system
  • Drug induced lacrimal canalicular stenosis
  • Drug induced pulmonary fibrosis
  • Drug induced thrombotic thrombocytopenic purpura
  • Drug induction of cytochrome p450 CYP1A2 enzyme
  • Drug induction of cytochrome p450 CYP2C19 enzyme
  • Drug induction of cytochrome p450 CYP2C9 enzyme
  • Drug induction of cytochrome p450 CYP3A enzyme
  • Drug inhibition of cytochrome p450 CYP1A2 enzyme
  • Drug inhibition of cytochrome p450 CYP2C19 enzyme
  • Drug inhibition of cytochrome p450 CYP2C9 enzyme
  • Drug inhibition of cytochrome p450 CYP2D6 enzyme
  • Drug inhibition of cytochrome p450 CYP3A enzyme
  • Drug interaction with drug
  • Drug interaction with tobacco
  • Drug pigmentation
  • Drug reaction AND/OR intoxication specific to newborn
  • Drug reaction with eosinophilia and systemic symptoms
  • Drug related visual impairment
  • Drug tolerance
  • Drug-aggravated angioedema-urticaria
  • Drug-exacerbated psoriasis
  • Drug-induced acanthosis nigricans
  • Drug-induced acute angle closure
  • Drug-induced acute cicatrizing conjunctivitis
  • Drug-induced acute dystonia
  • Drug-induced acute pancreatitis
  • Drug-induced acute pulmonary edema
  • Drug-induced adrenocortical insufficiency
  • Drug-induced adrenogenital disorder
  • Drug-induced anaphylaxis
  • Drug-induced androgenic alopecia
  • Drug-induced anetoderma
  • Drug-induced angioedema-urticaria
  • Drug-induced angle closure
  • Drug-induced angle closure glaucoma
  • Drug-induced angle closure glaucoma of bilateral eyes
  • Drug-induced angle closure glaucoma of left eye
  • Drug-induced angle closure glaucoma of right eye
  • Drug-induced apnea
  • Drug-induced asthma
  • Drug-induced autoimmune hemolytic anemia
  • Drug-induced autoimmune reaction
  • Drug-induced autonomic dysfunction
  • Drug-induced bradycardia
  • Drug-induced bronchiolitis obliterans
  • Drug-induced bullous pemphigoid
  • Drug-induced cataract
  • Drug-induced central nervous system depression
  • Drug-induced cerebellar ataxia
  • Drug-induced cholestatic hepatitis
  • Drug-induced chorea
  • Drug-induced chronic hepatitis
  • Drug-induced chronic pancreatitis
  • Drug-induced cicatricial pemphigoid
  • Drug-induced cirrhosis of liver
  • Drug-induced coagulation inhibitor disorder
  • Drug-induced colitis
  • Drug-induced coma
  • Drug-induced constipation
  • Drug-induced corneal epithelial deposit
  • Drug-induced cutis laxa
  • Drug-induced dermatomyositis
  • Drug-induced dermatosis
  • Drug-induced desquamation of skin
  • Drug-induced diabetes mellitus
  • Drug-induced disorder of cornea
  • Drug-induced disorder of liver
  • Drug-induced disorder of refraction AND/OR accommodation
  • Drug-induced dyskinesia
  • Drug-induced dyskinesia, acute onset
  • Drug-induced dystonia
  • Drug-induced embolism
  • Drug-induced encephalopathy
  • Drug-induced enteritis of intestine
  • Drug-induced enzyme deficiency anemia
  • Drug-induced eosinophilia
  • Drug-induced epidermolysis bullosa acquisita
  • Drug-induced epilepsy
  • Drug-induced erythema multiforme
  • Drug-induced erythromelalgia
  • Drug-induced feminization
  • Drug-induced fibrinolytic disorder
  • Drug-induced flushing
  • Drug-induced gingival hyperplasia
  • Drug-induced granulomatous mediastinitis
  • Drug-induced hair abnormality
  • Drug-induced hair color change
  • Drug-induced hepatic necrosis
  • Drug-induced hepatitis
  • Drug-induced hirsutism
  • Drug-induced hypergastrinemia
  • Drug-induced hyperglycemia
  • Drug-induced hyperhidrosis
  • Drug-induced hyperinsulinemia
  • Drug-induced hyperkalemia
  • Drug-induced hypermelanosis
  • Drug-induced hyperprolactinemia
  • Drug-induced hyperpyrexia
  • Drug-induced hypersomnia
  • Drug-induced hypertrichosis
  • Drug-induced hypocalcemia
  • Drug-induced hypoglycemia
  • Drug-induced hypoglycemia without coma
  • Drug-induced hypokalemia
  • Drug-induced hypomagnesemia
  • Drug-induced hypomelanosis
  • Drug-induced hyponatremia
  • Drug-induced hypoplasia of bone marrow
  • Drug-induced hypotension
  • Drug-induced ichthyosiform reaction
  • Drug-induced ileus
  • Drug-induced immune hemolytic anemia, hapten type
  • Drug-induced immune hemolytic anemia, immune complex type
  • Drug-induced immune-complex glomerulonephritis
  • Drug-induced immunodeficiency
  • Drug-induced interstitial lung disorder
  • Drug-induced intrahepatic cholestasis
  • Drug-induced keratoconjunctivitis
  • Drug-induced lesion
  • Drug-induced leukonychia
  • Drug-induced linear IgA disease
  • Drug-induced lupus erythematosus
  • Drug-induced lymphocytic vasculitis
  • Drug-induced male infertility
  • Drug-induced megacolon
  • Drug-induced melasma
  • Drug-induced membranous nephropathy
  • Drug-induced methemoglobinemia
  • Drug-induced mucositis
  • Drug-induced myasthenia
  • Drug-induced myoclonus
  • Drug-induced myopathy
  • Drug-induced nail abnormality
  • Drug-induced nail fragility
  • Drug-induced nail hypertrophy
  • Drug-induced necrotizing vasculitis
  • Drug-induced neutropenia
  • Drug-induced neutrophilia
  • Drug-induced non autoimmune hemolytic anemia
  • Drug-induced obesity
  • Drug-induced ocular hypertension
  • Drug-induced ocular hypertension of left eye
  • Drug-induced ocular hypertension of right eye
  • Drug-induced open angle glaucoma
  • Drug-induced open angle glaucoma of bilateral eyes
  • Drug-induced open angle glaucoma of left eye
  • Drug-induced open angle glaucoma of right eye
  • Drug-induced oral condition
  • Drug-induced oral lichenoid reaction
  • Drug-induced oral pigmentation
  • Drug-induced oral ulceration
  • Drug-induced orofacial dyskinesia
  • Drug-induced osteoporosis
  • Drug-induced osteoporosis with osteoporotic fracture
  • Drug-induced palmoplantar pustular psoriasis
  • Drug-induced panniculitis
  • Drug-induced pemphigus
  • Drug-induced pemphigus foliaceus
  • Drug-induced pemphigus vulgaris
  • Drug-induced peptic ulcer
  • Drug-induced pericarditis
  • Drug-induced persistent light reaction
  • Drug-induced pigmentation
  • Drug-induced pigmentation of cornea
  • Drug-induced pleural effusion
  • Drug-induced pleurisy
  • Drug-induced pneumonitis
  • Drug-induced polymyositis
  • Drug-induced porphyria
  • Drug-induced pseudoporphyria
  • Drug-induced pseudoscleroderma
  • Drug-induced pseudoxanthoma elasticum
  • Drug-induced purpura
  • Drug-induced Raynaud's phenomenon
  • Drug-induced retinopathy
  • Drug-induced sideroblastic anemia
  • Drug-induced solar urticaria
  • Drug-induced Stevens-Johnson syndrome
  • Drug-induced stricture of esophagus
  • Drug-induced systemic lupus erythematosus
  • Drug-induced tardive dystonia
  • Drug-induced telangiectasia
  • Drug-induced thyroiditis
  • Drug-induced tubulointerstitial nephritis
  • Drug-induced uveitis
  • Drug-induced virilization
  • Drug-induced xerostomia
  • Drug-related alopecia
  • Drug-related myocardial necrosis syndrome
  • Duodenal ulcer caused by drug
  • Duodenitis caused by drug
  • Dysfunction of vestibular system
  • Dysmotility of small intestine caused by drug
  • Effect of drug maladministration
  • Effects of immunotherapy
  • Emollient adverse reaction
  • Endocrine alopecia
  • Endocrine drug side effect
  • Enlargement of alveolar ridge
  • ENT disorder monitoring status
  • ENT drug side effect
  • Epidermal fragility
  • Eruption caused by drug
  • Erythema nodosum caused by drug
  • Erythroderma caused by drug
  • Erythromelalgia
  • Esophagitis medicamentosa
  • Exanthematous disorder
  • Excessive muscarinic activity
  • Exogenous pigmentation of oral mucosa
  • Extrinsic staining of teeth caused by drug
  • Factor IX inhibitor disorder
  • Factor V inhibitor disorder
  • Factor VIII inhibitor disorder
  • Falls
  • Falls caused by medication
  • Fat hypertrophy
  • Fat hypertrophy due to injection of drug or medicament
  • Feminization
  • Fixed drug eruption
  • Fixed drug reaction
  • Fixed drug reaction affecting oral mucous membranes
  • Folate deficiency anemia, drug-induced
  • Gastric erosion
  • Gastric ulcer caused by drug
  • Gastritis medicamentosa
  • Gastroenteritis caused by drug
  • Gastrointestinal disorder caused by drug
  • Generalized bullous fixed drug eruption
  • Generalized hypoplasia of enamel caused by ingestion of drug
  • Generalized rash
  • Generalized skin eruption caused by drug and medicament
  • Gingival disease caused by drug
  • Gingival enlargement exacerbated by drug
  • Gingivitis caused by drug
  • Gout of ankle and/or foot caused by drug
  • Gout of elbow caused by drug
  • Gout of hand caused by drug
  • Gout of hip caused by drug
  • Gout of knee caused by drug
  • Gout of multiple sites caused by drug
  • Gout of shoulder caused by drug
  • Gout of vertebra caused by drug
  • Gout of wrist caused by drug
  • Gout secondary to drug
  • Granulomatous mediastinitis
  • Gray syndrome from chloramphenicol administration in newborn
  • Gyne. drug side effect
  • Gynecologic disorder monitoring status
  • Hapten type high affinity hemolytic anemia
  • Hapten type low affinity hemolytic anemia
  • Headache caused by drug
  • Heart block caused by drug
  • Hemolytic anemia caused by drugs
  • Herbal medicine adverse reaction
  • High risk drug monitoring status
  • High risk drug side effect
  • Homeopathic medicine adverse reaction
  • Hot flash caused by medication
  • Hypercalcemia caused by a drug
  • Hyperkalemia
  • Hyperosmolar coma due to diabetes mellitus
  • Hyperosmolar coma due to drug induced diabetes mellitus
  • Hyperosmolar coma due to secondary diabetes mellitus
  • Hyperosmolarity due to drug induced diabetes mellitus
  • Hyperosmolarity due to secondary diabetes mellitus
  • Hyperplasia of gingiva
  • Hyperpyrexia
  • Hypersensitivity disease of liver caused by drug
  • Hypertension secondary to drug
  • Hypertrophy of nail
  • Hypocellular bone marrow
  • Hypophysectomy-induced hypopituitarism
  • Hypophysitis caused by drug
  • Hypopituitarism caused by drug
  • Hypopituitarism following procedure
  • Hyposecretion of salivary gland
  • Hypospermatogenesis
  • Hypothyroidism caused by drug
  • Iatrogenic adrenal insufficiency
  • Iatrogenic hypoglycemia
  • Iatrogenic hypopituitarism
  • Iatrogenic pituitary disorder
  • Iatrogenic thyroiditis
  • Idiosyncratic drug effect
  • Immune complex small vessel vasculitis caused by drug
  • Immune complex urticaria
  • Immune-complex glomerulonephritis
  • Immunodeficiency caused by long term therapeutic use of drug
  • Immunotherapy induced hypophysitis
  • Impaired glucose tolerance associated with drugs
  • Increased gastrin secretion
  • Induced spermatogenic arrest
  • Infertility due to drug therapy
  • Inflammatory red colored lesion of internal part of mouth caused by drug
  • Insufficiency fracture
  • Interstitial pulmonary fibrosis due to inhalation of drug
  • Interstitial pulmonary fibrosis due to inhalation of substance
  • Intolerance to drug
  • Intractable headache caused by drug
  • Intraoperative floppy iris syndrome
  • Intraoperative floppy iris syndrome of left eye
  • Intraoperative floppy iris syndrome of right eye
  • Intravenous nutrition adverse reaction
  • Intrinsic staining of tooth - drug-induced
  • Irritant contact dermatitis caused by drug in contact with skin
  • Keratopathy of left eye caused by drug
  • Keratopathy of right eye caused by drug
  • Leukopenia caused by drug
  • Lichenoid drug eruption
  • Linear IgA dermatosis
  • Localized eruption of skin
  • Localized pustular psoriasis
  • Localized skin eruption caused by drug and medicament
  • Long QT syndrome caused by drug
  • Lubricant adverse reaction
  • Lyell syndrome
  • Lymphocyte count below reference range
  • Lymphocytic vasculitis of skin
  • Maculopapular drug eruption
  • Maculopapular eruption
  • Malabsorption caused by drug
  • Male coital disorder
  • Male pattern alopecia
  • Medication bezoar
  • Medication overuse headache
  • Medication side effects present
  • Medication-induced ejaculation disorder
  • Medication-induced movement disorder
  • Medication-induced postural tremor
  • Megaloblastic anemia caused by drugs
  • Motility disorder of small intestine
  • Multiple drug intolerant hypertension
  • Myelofibrosis
  • Myelofibrosis caused by drug
  • Myocarditis caused by drug
  • Myotonia caused by drug
  • Nail color change due to ingested drug
  • Nail dystrophy due to cytotoxic therapy
  • Nail fragility
  • Nausea and vomiting
  • Nausea and vomiting caused by drug
  • Neonatal drug reaction and intoxication
  • Neonatal perforation of intestine caused by drug
  • Nephritis caused by drug
  • Nephropathy due to secondary diabetes mellitus
  • Neurological disorder monitoring status
  • Neurological drug side effects
  • Neuropathy associated with hypoglycemia
  • Neutrophilia disorder
  • Neutrophilic eccrine hidradenitis
  • Neutrophilic eccrine hidradenitis due to cytotoxic therapy
  • Newborn drug intoxication
  • Newborn drug reaction
  • Niacin deficiency
  • Non dose-related adverse reaction to medication
  • Non dose-related drug-induced neutropenia
  • Non-allergic anaphylaxis caused by drug
  • Non-autoimmune hemolytic anemia
  • Non-diabetic hypoglycemia
  • Non-melanin pigmentation caused by drug
  • Non-pigmenting fixed drug eruption
  • Nonspecific interstitial pneumonia
  • Nonspecific interstitial pneumonia caused by medication
  • Obstructive hyperbilirubinemia
  • Ocular cicatricial pemphigoid
  • Oligozoospermia
  • Oligozoospermia due to drug therapy
  • Onycholysis
  • Oral lichenoid reaction
  • Organic sleep disorder
  • Organic sleep related movement disorder
  • Organized pneumonia
  • Organizing pneumonia caused by medication
  • Orofacial dyskinesia
  • Osteomalacia secondary to drug
  • Osteonecrosis caused by drug
  • Osteonecrosis of ankle caused by drug
  • Osteonecrosis of carpus caused by drug
  • Osteonecrosis of femur caused by drug
  • Osteonecrosis of fibula
  • Osteonecrosis of fibula caused by drug
  • Osteonecrosis of finger caused by drug
  • Osteonecrosis of hand caused by drug
  • Osteonecrosis of jaw
  • Osteonecrosis of jaw caused by drug
  • Osteonecrosis of pelvis
  • Osteonecrosis of pelvis caused by drug
  • Osteonecrosis of radius
  • Osteonecrosis of radius caused by drug
  • Osteonecrosis of shoulder caused by drug
  • Osteonecrosis of tibia
  • Osteonecrosis of tibia caused by drug
  • Osteonecrosis of toe caused by drug
  • Osteopenia caused by drug
  • Ototoxicity
  • Ototoxicity - labyrinthine
  • Pain following administration of agent
  • Palpation thyroiditis
  • Parkinsonism caused by drug
  • Pellagra
  • Pellagra caused by drug
  • Pemphigus foliaceus
  • Pemphigus vulgaris
  • Persistent miosis
  • Pharmaceutical fluid or solution adverse reaction
  • Pharmacologic parasympathicotonic pupil
  • Pharmacological paralysis of accommodation
  • Photoonycholysis
  • Photoonycholysis caused by drug
  • Photosensitivity caused by drug
  • Phototoxic drug eruption
  • Pityriasis rosea-like drug eruption
  • Pleuroparenchymal fibroelastosis
  • Pleuroparenchymal fibroelastosis caused by medication
  • Pleurothotonus
  • Polymyositis
  • Polyneuropathy caused by drug
  • Polyneuropathy due to diabetes mellitus
  • Polyneuropathy due to drug induced diabetes mellitus
  • Polyneuropathy due to secondary diabetes mellitus
  • Porphyrin within reference range
  • Posteruptive color change of tooth
  • Posteruptive teeth staining
  • Posteruptive tooth staining caused by drug
  • Pre-eruptive color change of tooth
  • Priapism
  • Priapism caused by drug
  • Pruritus caused by drug
  • Pseudolymphomatous eruption caused by drug
  • Pseudoporphyria
  • Pseudoscleroderma due to cytotoxic therapy
  • Pseudoxanthoma elasticum
  • Psoriasiform drug eruption
  • Pulmonary arterial hypertension induced by drug
  • Pulmonary toxicity
  • Purpura due to drug-induced capillary damage
  • Purpura due to drug-induced coagulation abnormality
  • Pustular psoriasis of palm of hand
  • Pustular psoriasis of palms and soles
  • Pustular psoriasis of sole of foot
  • Radiation recall reaction due to cytotoxic therapy
  • Raynaud's phenomenon
  • Rectal hemorrhage caused by drug
  • Renal hypersensitivity caused by drug
  • Renal tubular defect
  • Renal tubular dysgenesis caused by drug
  • Respiratory bronchiolitis interstitial lung disease
  • Respiratory bronchiolitis interstitial lung disease caused by medication
  • Respiratory disorder caused by drug
  • Restlessness
  • Retention of urine
  • Retention of urine caused by drug
  • Salivary dysfunction caries secondary to medication
  • Salivary dysfunction dental caries
  • Scleroderma-like secondary cutaneous sclerosis
  • Secondary acquired sideroblastic anemia
  • Secondary acute eosinophilic pneumonia
  • Secondary alveolar macrophage pneumonia
  • Secondary bronchiolocentric interstitial pneumonia
  • Secondary cerebellar degeneration
  • Secondary chronic eosinophilic pneumonia
  • Secondary cutaneous vasculitis
  • Secondary eosinophilia
  • Secondary erythromelalgia
  • Secondary hyperprolactinemia
  • Secondary hypomagnesemia
  • Secondary nonspecific interstitial pneumonia
  • Secondary organizing pneumonia
  • Secondary pleuroparenchymal fibroelastosis
  • Secondary respiratory bronchiolitis interstitial lung disease
  • Secondary systemic vasculitis
  • Secondary thrombocytopenia
  • Secondary usual interstitial pneumonia
  • Serum sickness caused by drug
  • Sinus bradycardia
  • Sinus bradycardia caused by drug
  • Sleep-related movement disorder caused by drug
  • Small vessel pulmonary hypertension
  • Small vessel vasculitis caused by immune complex
  • Solar urticaria
  • Solitary pulmonary hypertension
  • Spermatogenic arrest
  • Staining of teeth
  • Starch peritonitis
  • Stenosis of lacrimal canaliculi
  • Stevens Johnson syndrome AND toxic epidermal necrolysis overlap
  • Stevens-Johnson and toxic epidermal necrolysis overlap syndrome caused by drug
  • Stevens-Johnson syndrome
  • Stevens-Johnson syndrome, toxic epidermal necrolysis spectrum
  • Stomatitis medicamentosa
  • Strength of nails - finding
  • Stricture of esophagus
  • Subacute dyskinesia caused by drug
  • Substance induction of cytochrome p450 CYP1A2 enzyme
  • Substance induction of cytochrome p450 CYP3A enzyme
  • Substance induction of cytochrome p450 enzyme
  • Substance inhibition of cytochrome p450 CYP3A enzyme
  • Substance inhibition of cytochrome p450 enzyme
  • Substance-induced ataxia
  • Sweet's disease caused by drug
  • Swelling of gingival and edentulous alveolar ridge caused by drug
  • Swelling of oral cavity structure
  • Swollen gums
  • Sympathoparetic pupil caused by drug
  • Syringosquamous metaplasia due to cytotoxic therapy
  • Tardive dyskinesia
  • T-cell pseudolymphoma caused by drug
  • Teeth staining caused by drugs
  • Telogen effluvium
  • Telogen hair loss caused by drug
  • Thrombocytopenia caused by drugs
  • Thrombotic thrombocytopenic purpura
  • Tic caused by drug
  • Torsades de pointe caused by drug
  • Torsades de pointes
  • Toxic adverse drug interaction with drug
  • Toxic anagen effluvium
  • Toxic cardiomyopathy
  • Toxic cataract
  • Toxic chorea
  • Toxic dilated cardiomyopathy
  • Toxic disorder of refraction AND/OR accommodation
  • Toxic dystonia
  • Toxic enteritis of small intestine caused by drug
  • Toxic epidermal necrolysis caused by drug
  • Toxic keratoconjunctivitis
  • Toxic neuromuscular junction disorder
  • Toxic polyneuropathy
  • Toxic pulmonary edema
  • Tremor due to harmful pattern of substance use
  • Ulcer caused by drug
  • Ulcer of anus
  • Ulcer of esophagus caused by ingestion of medicine
  • Ulcer of foot due to drug induced diabetes mellitus
  • Ultraviolet recall reaction due to cytotoxic therapy
  • Urticaria medicamentosa
  • Usual interstitial pneumonia
  • Usual interstitial pneumonia caused by medication
  • Vasculitis caused by drug
  • Ventricular tachycardia, polymorphic
  • Vertigo caused by drug
  • Vitamin B12 deficiency anemia caused by drug
  • Xerostomia

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T50.905A: its own notes plus those printed at T50, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Code First

The underlying condition named in the note is sequenced before this code.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T50 Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances applies to 342 codes
  • The appropriate 7th character is to be added to each code from category T50
  • Ainitial encounter this code
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T50.905A, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming T50.905A: they are not reported together with it, unless the two conditions are unrelated.

  • T38 Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified
    parathyroid hormones and derivatives (T50.9-) names T50.9-, which includes this code

Use Additional Code 1

These codes say to use an additional code from the note, and T50.905A is one of the codes named.

  • G61.1 Serum neuropathy
    code for adverse effect, if applicable, to identify serum (T50.-) names T50.-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ028
Adverse effects of drugs and medicaments, initial encounter
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
Acidifying agent NECT50.901T50.902T50.903T50.904T50.905T50.906
Adjunct, pharmaceuticalT50.901T50.902T50.903T50.904T50.905T50.906
Alkalinizing agents (medicinal)T50.901T50.902T50.903T50.904T50.905T50.906
Alkalizing agent NECT50.901T50.902T50.903T50.904T50.905T50.906
Biological substance NECT50.901T50.902T50.903T50.904T50.905T50.906
Dietetic drug NECT50.901T50.902T50.903T50.904T50.905T50.906
Drug NECT50.901T50.902T50.903T50.904T50.905T50.906
Dye NEC::pharmaceutical NECT50.901T50.902T50.903T50.904T50.905T50.906
Elemental dietT50.901T50.902T50.903T50.904T50.905T50.906
Excipients, pharmaceuticalT50.901T50.902T50.903T50.904T50.905T50.906
Headache cures, drugs, powders NECT50.901T50.902T50.903T50.904T50.905T50.906
Lactose (as excipient)T50.901T50.902T50.903T50.904T50.905T50.906
Lipotropic drug NECT50.901T50.902T50.903T50.904T50.905T50.906
Medicament NECT50.901T50.902T50.903T50.904T50.905T50.906
Nutritional supplementT50.901T50.902T50.903T50.904T50.905T50.906
Pharmaceutical::adjunct NECT50.901T50.902T50.903T50.904T50.905T50.906
Pharmaceutical::excipient NECT50.901T50.902T50.903T50.904T50.905T50.906
Pharmaceutical::sweetenerT50.901T50.902T50.903T50.904T50.905T50.906
Pharmaceutical::viscous agentT50.901T50.902T50.903T50.904T50.905T50.906
Preservative (nonmedicinal)::medicinalT50.901T50.902T50.903T50.904T50.905T50.906
SaccharinT50.901T50.902T50.903T50.904T50.905T50.906
Salt substituteT50.901T50.902T50.903T50.904T50.905T50.906
Salt-replacing drugT50.901T50.902T50.903T50.904T50.905T50.906
Sodium-free saltT50.901T50.902T50.903T50.904T50.905T50.906
Soothing syrupT50.901T50.902T50.903T50.904T50.905T50.906
Spray (aerosol)::medicinal NECT50.901T50.902T50.903T50.904T50.905T50.906
StarchT50.901T50.902T50.903T50.904T50.905T50.906
Stone-dissolving drugT50.901T50.902T50.903T50.904T50.905T50.906
SweetenerT50.901T50.902T50.903T50.904T50.905T50.906
Tablets [See Also: specified substance]T50.901T50.902T50.903T50.904T50.905T50.906
Tonic NECT50.901T50.902T50.903T50.904T50.905T50.906
Viscous agentT50.901T50.902T50.903T50.904T50.905T50.906

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T50.905A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
995.20 Adv eff med/biol sub NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E947.9 Adv eff medicinal NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T50.905AOverview

Is T50.905A a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of unspecified drugs, medicaments and biological substances, initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character A in T50.905A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for adverse effect of unspecified drugs, medicaments and biological substances, such as an emergency visit or first evaluation.

What MS-DRG does T50.905A group to?

When adverse effect of unspecified drugs, medicaments and biological substances, initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 918, 917, with relative weights from 0.8716 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.

Can T50.905A be reported with a code from O29.3?

Not as a rule. The Excludes1 note at block T36-T50, which applies to T50.905A, lists "toxic reaction to local anesthesia in pregnancy (O29.3-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of T50.905A?

Under the General Equivalence Mappings, adverse effect of unspecified drugs, medicaments and biological substances, initial encounter converts to ICD-9-CM 995.20 (adv eff med/biol sub NOS) and E947.9 (adv eff medicinal NOS). The mapping is approximate, so confirm the match fits the documentation.