2026 ICD-10-CM Diagnosis Code T50.905AAdverse effect of unspecified drugs, medicaments and biological substances, initial encounter

AHRQ’s CCSR groups this code into broader clinical categories.

• Tardive Dyskinesia

  drug-related movement disorder characterized by uncontrollable movements in certain muscles. it is associated with a long-term exposure to certain neuroleptic medications (e.g., metoclopramide).

• Hyperkalemia

  abnormally high potassium concentration in the blood, most often due to defective renal excretion. it is characterized clinically by electrocardiographic abnormalities (elevated t waves and depressed p waves, and eventually by atrial asystole). in severe cases, weakness and flaccid paralysis may occur. (dorland, 27th ed)

• Pseudohypoaldosteronism

  a heterogeneous group of disorders characterized by renal electrolyte transport dysfunctions. congenital forms are rare autosomal disorders characterized by neonatal hypertension, hyperkalemia, increased renin activity and aldosterone concentration. the type i features hyperkalemia with sodium wasting; type ii, hyperkalemia without sodium wasting. pseudohypoaldosteronism can be the result of a defective renal electrolyte transport protein or acquired after kidney transplantation.

• Anetoderma

  benign dermatosis caused by a loss of dermal elastic tissue resulting in localized sac-like areas of flaccid skin. it can be either primary (idiopathic) or secondary to other skin conditions, penicillamine use, or premature birth.

• Pseudoxanthoma Elasticum

  an inherited disorder of connective tissue with extensive degeneration and calcification of elastic tissue primarily in the skin, eye, and vasculature. at least two forms exist, autosomal recessive and autosomal dominant. this disorder is caused by mutations of one of the atp-binding cassette transporters. patients are predisposed to myocardial infarction and gastrointestinal hemorrhage.

• Dermatomyositis

  a subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. the illness occurs with approximately equal frequency in children and adults. the skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. the disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. the childhood form of this disease tends to evolve into a systemic vasculitis. dermatomyositis may occur in association with malignant neoplasms. (from adams et al., principles of neurology, 6th ed, pp1405-6)

• Polymyositis

  diseases characterized by inflammation involving multiple muscles. this may occur as an acute or chronic condition associated with medication toxicity (drug toxicity); connective tissue diseases; infections; malignant neoplasms; and other disorders. the term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. the illness may occur at any age, but is most frequent in the fourth to sixth decade of life. weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (adams et al., principles of neurology, 6th ed, pp1404-9)

• Torsades de Pointes

  a malignant form of polymorphic ventricular tachycardia that is characterized by heart rate between 200 and 250 beats per minute, and qrs complexes with changing amplitude and twisting of the points. the term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long qt intervals exceeding 500 milliseconds or bradycardia. torsades de pointes may be self-limited or may progress to ventricular fibrillation.

• Erythromelalgia

  a peripheral arterial disease that is characterized by the triad of erythema, burning pain, and increased skin temperature of the extremities (or red, painful extremities). erythromelalgia may be classified as primary or idiopathic, familial or non-familial. secondary erythromelalgia is associated with other diseases, the most common being myeloproliferative disorders.

• Hirsutism

  a condition observed in women and children when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. it is the result of elevated androgens from the ovaries, the adrenal glands, or exogenous sources. the concept does not include hypertrichosis, which is an androgen-independent excessive hair growth.

• Acanthosis Nigricans

  a circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. it occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.

• Pellagra

  a disease due to deficiency of niacin, a b-complex vitamin, or its precursor tryptophan. it is characterized by scaly dermatitis which is often associated with diarrhea and dementia (the three d's).

• Androgen-Insensitivity Syndrome

  a disorder of sexual development transmitted as an x-linked recessive trait. these patients have a karyotype of 46,xy with end-organ resistance to androgen due to mutations in the androgen receptor (receptors, androgen) gene. severity of the defect in receptor quantity or quality correlates with their phenotypes. in these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in reifenstein syndrome, to that of a normal male with infertility.

• Feminization

  development of female secondary sex characteristics in the male. it is due to the effects of estrogenic metabolites of precursors from endogenous or exogenous sources, such as adrenal glands or therapeutic drugs.

• Priapism

  a prolonged painful erection that may lasts hours and is not associated with sexual activity. it is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma; and certain drug treatments.

• Onycholysis

  separation of nail plate from the underlying nail bed. it can be a sign of skin disease, infection (such as onychomycosis) or tissue injury.

• Xerostomia

  decreased salivary flow.

• Drug Tolerance

  progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. it should be differentiated from drug resistance wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. it should also be differentiated from maximum tolerated dose and no-observed-adverse-effect level.

• Ototoxicity

  damage to the ear or its function secondary to exposure to toxic substances such as drugs used in chemotherapy; immunotherapy; or radiation.

• Metoclopramide

  a dopamine d2 antagonist that is used as an antiemetic.

• Onychomycosis

  a fungal infection of the nail, usually caused by dermatophytes; yeasts; or nondermatophyte molds.

• Grade 1 Hyperkalemia, CTCAE|Grade 1 Hyperkalemia

  >uln - 5.5 mmol/l

• Grade 2 Hyperkalemia, CTCAE|Grade 2 Hyperkalemia

  >5.5 - 6.0 mmol/l; intervention initiated

• Grade 3 Hyperkalemia, CTCAE|Grade 3 Hyperkalemia

  >6.0 - 7.0 mmol/l; hospitalization indicated

• Grade 2 Akathisia, CTCAE|Grade 2 Akathisia

  moderate restlessness or increased motor activity; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Akathisia, CTCAE|Grade 3 Akathisia

  severe restlessness or increased motor activity; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Androgen-dependent Hirsutism|Androgen-dependent hirsutism

  hirsutism that arises from an excess of male hormones.

• Bronchospasm, CTCAE|Bronchospasm|Bronchospasm

  a disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall or narrowing of the airway. may be manifested as wheezing.

• Grade 2 Bronchospasm, CTCAE|Grade 2 Bronchospasm

  symptomatic; medical intervention indicated; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Bronchospasm, CTCAE|Grade 3 Bronchospasm

  supplemental oxygen indicated; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Chronic Toxic Polyneuropathy

  neuropathy affecting multiple nerves that is caused by prolonged exposure to toxic substances.

• Anagen Effluvium

  non-scarring alopecia arising during the growth (anagen) phase of the hair cycle. it may be associated with chemotherapy, exposure to radiation or heavy metals, poor nutrition, or various autoimmune conditions.

• Grade 1 Hyperkalemia, CTCAE|Grade 1 Hyperkalemia

  >uln-5.5 mmol/l

• Grade 2 Hyperkalemia, CTCAE|Grade 2 Hyperkalemia

  >5.5-6.0 mmol/l; intervention initiated

• Grade 3 Hyperkalemia, CTCAE|Grade 3 Hyperkalemia

  >6.0-7.0 mmol/l; hospitalization indicated

• Grade 4 Hyperkalemia, CTCAE|Grade 4 Hyperkalemia

  >7.0 mmol/l; life-threatening consequences

• Grade 5 Hyperkalemia, CTCAE|Grade 5 Hyperkalemia

  death

• Hyperkalemia

  higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs.

• Hyperkalemia, CTCAE|Hyperkalemia|Hyperkalemia

  a disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.

• Hyperkalemic Mineralocorticoid Resistance|Chloride Shunt Syndrome|Familial Hyperkalemic Hypertension|Gordon Hyperkalemia|Mineralocorticoid Resistant Hyperkalemia|PHA Type 2|Pseudohypoaldosteronism, Type II|Spitzer-Weinstein Syndrome

  a genetically heterogynous condition characterized by hyperkalemia, hyperchloremic acidosis, low or suppressed renin activity, and normal to high concentrations of aldosterone. mutations in genes (for example wnk1 or wnk4), regulating na-cl cotransporters (ncc), na-k-cl cotransporters (nkcc2), or the renal outer medullary potassium (romk) channel have been identified as causative in this condition. the primary abnormality is thought to be a specific defect of the renal secretory mechanism for potassium, which limits the kaliuretic response to, but not the sodium and chloride reabsorptive effect of, mineralocorticoid.

• Chemical Peritonitis

  a non-infectious inflammation of the peritoneum.

• Neutrophilic Eccrine Hidradenitis

  painful red or pink edematous nodules most commonly found on the palmar and/or plantar regions.

• ABCC6 wt Allele|ABC34|ARA|ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 wt Allele|ATP-Binding Cassette, Subfamily C, Member 6 Gene|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|Pseudoxanthoma Elasticum Gene|URG7

  human abcc6 wild-type allele is located in the vicinity of 16p13.1 and is approximately 75 kb in length. this allele, which encodes multidrug resistance-associated protein 6, plays a role in the active transport of drugs across the plasma membrane. mutation of the gene is associated with pseudoxanthoma elasticum and generalized arterial calcification of infancy type 2.

• Pseudoxanthoma Elasticum

  a rare, progressive, autosomal recessive inherited disorder caused by mutations in the abcc6 gene. it is characterized by calcification and fragmentation of the elastic fibers of the skin, retina, and cardiovascular system. signs and symptoms include skin plaques and bumps, thickened skin, retinal hemorrhage and obstruction of the blood vessels.

• Spastic Paraplegia 56|Autosomal Recessive Spastic Paraplegia-56 with or without Pseudoxanthoma Elasticum|SPG56

  an autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the cyp2u1 gene, encoding cytochrome p450 2u1.

• Central Sleep Apnea Syndrome

  a broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to cheyne-stokes breathing pattern, central sleep apnea due to medical condition not cheyne-stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. it is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. in adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. it is more common in older males and may present as a co-morbid condition to obesity. clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health.

• Akathisia

  an uncomfortable feeling of inner restlessness and inability to stay still. it can be a side effect of psychotropic medications.

• Akathisia, CTCAE|Akathisia|Akathisia

  a disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.

• Barnes Akathisia Rating Scale Clinical Classification|BARS|BARS|BARS01

  a standardized rating scale developed by thomas r. e. barnes in 1989 to diagnose akathisia associated with use of antipsychotic agents. this instrument contains objective and subjective sections, as well as a global clinical assessment of akathisia. the first two sections contain a total of 3 items which are rated on a scale of 0 to 3 with 0 being none or normal and 3 being severe. the third section is rated on a 0 to 5 scale with 0 being none and 5 being severe.

• CDISC Clinical Classification BARS Test Code Terminology|BARS01TC|Barnes Akathisia Rating Scale Clinical Classification Test Code|QS-BARS TESTCD

  test codes of clinical classification questions associated with the barnes akathisia rating scale (bars) for the clinical data interchange standards consortium (cdisc) standard data tabulation model (sdtm).

• CDISC Clinical Classification BARS Test Name Terminology|BARS01TN|Barnes Akathisia Rating Scale Clinical Classification Test Name|QS-BARS TEST

  test names of clinical classification questions associated with the barnes akathisia rating scale (bars) for the clinical data interchange standards consortium (cdisc) standard data tabulation model (sdtm).

• Drug-Induced Akathisia|Drug induced akathisia

  evidence of drug-induced akathisia.

• ESRS-A - Akathisia: Objective|ESRSA1-Akathisia: Objective|ESRSA1-Akathisia: Objective|ESRSA124

  extrapyramidal symptom rating scale-abbreviated (esrs-a) akathisia: objective.

• ESRS-A - Akathisia: Subjective|ESRSA1-Akathisia: Subjective|ESRSA1-Akathisia: Subjective|ESRSA123

  extrapyramidal symptom rating scale-abbreviated (esrs-a) akathisia: subjective.

• ESRS-A - CGI-S Akathisia|ESRSA1-CGI-S Akathisia|ESRSA1-CGI-S Akathisia|ESRSA128

  extrapyramidal symptom rating scale-abbreviated (esrs-a) clinical global impression (cgi-s): akathisia.

• Grade 1 Akathisia, CTCAE|Grade 1 Akathisia

  mild restlessness or increased motor activity

• Grade 2 Akathisia, CTCAE|Grade 2 Akathisia

  moderate restlessness or increased motor activity; limiting instrumental adl

• Grade 3 Akathisia, CTCAE|Grade 3 Akathisia

  severe restlessness or increased motor activity; limiting self care adl

• Aseptic Meningitis

  inflammation of the membranes surrounding the brain and spinal cord without a bacterial pathogen.

• Ocular Cicatricial Pemphigoid

  a chronic autoimmune disorder that belongs to the mucous membrane pemphigoid disorders. it is characterized by bilateral scarring and opacification of the conjunctivae. it presents with pain and burning sensation in the eyes and photophobia. it leads to blindness.

• Benign Mucous Membrane Pemphigoid

  a chronic autoimmune disorder characterized by the development of blisters and ulcers in mucous membranes. it affects most often the gums, eyelids and genital mucosa sites.

• Erythromelalgia

  a rare disorder characterized by periodic inflammation and blockage of the vessels of the extremities, resulting in skin redness, swelling, and burning pain in the affected sites. it may manifest as a primary disorder caused by mutations of the scn9a gene or as a secondary disorder due to hematologic disorders or medication side effects.

• Primary Erythermalgia|PERYTHM|Primary Erythromelalgia

  an autosomal dominant condition caused by mutation(s) in the scn9a gene, encoding sodium channel protein type 9 subunit alpha. it is characterized by episodes of recurrent warmth, redness, and burning sensations in the extremities.

• Primary Erythromelalgia|PERYTHM|Primary Erythermalgia

  an autosomal dominant condition caused by mutation(s) in the scn9a gene, encoding sodium channel protein type 9 subunit alpha. it is characterized by episodes of recurrent warmth, redness, and burning sensations in the extremities.

• Telogen Effluvium

  a scalp hair loss condition characterized by excessive shedding of hair in the resting phase of growth, usually following a fever or major body stress.

• Grade 1 Hirsutism, CTCAE|Grade 1 Hirsutism

  in women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair

• Grade 2 Hirsutism, CTCAE|Grade 2 Hirsutism

  in women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact

• Hirsutism

  male-pattern hair growth on a female.

• Hirsutism, CTCAE|Hirsutism|Hirsutism

  a disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen).

• Acanthosis Nigricans

  a melanotic cutaneous lesion that develops in the axilla and other body folds. it may be idiopathic, drug-induced, or it may be associated with the presence of an endocrine disorder or malignancy.

• Hyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome|HAIR-AN Syndrome

  a condition characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans, typically associated with obesity in teenage girls. it is considered to be a subtype of polycystic ovarian syndrome, but may occur in male individuals. etiology is unclear, but some cases may be associated with mutations affecting the tyrosine kinase domain of the insulin receptor.

• Insulin Resistant Diabetes Mellitus with Acanthosis Nigricans and Hyperandrogenism|Type A Insulin Resistance Syndrome

  a syndrome of insulin resistance caused by mutation(s) in the insr gene, encoding the insulin receptor. this condition is characterized by a clinical triad of hyperinsulinemia, acanthosis nigricans, and hyperandrogenism without lipodystrophy. this is the least severe of a spectrum of disorders; the other two conditions are rabson-mendenhall syndrome and donohoe syndrome.

• Hyperpyrexia

  body temperature of 106 degrees fahrenheit (41.1 degrees celsius) or higher.

• Malignant Hyperthermia Syndrome|Malignant Hyperpyrexia|Malignant Hyperthermia|Malignant Hyperthermia

  a rare disorder characterized by rapid rise of the body temperature, accompanied by rhabdomyolysis and, if untreated, by collapse and death. it occurs in susceptible individuals who receive certain drugs for general anesthesia, gas anesthetics, or succinylcholine. it may be inherited in an autosomal dominant pattern.

• Bronchospasm

  sudden contraction of the smooth muscles of the bronchial wall.

• Bronchospasm, CTCAE|Bronchospasm|Bronchospasm

  a disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall.

• Exercise-Induced Bronchospasm|Exercise induced bronchospasm

  sudden contraction of the smooth muscles of the bronchial wall that occurs during or following exercise.

• Grade 1 Bronchospasm, CTCAE|Grade 1 Bronchospasm

  mild symptoms; intervention not indicated

• Grade 2 Bronchospasm, CTCAE|Grade 2 Bronchospasm

  symptomatic; medical intervention indicated; limiting instrumental adl

• Grade 3 Bronchospasm, CTCAE|Grade 3 Bronchospasm

  limiting self care adl; supplemental oxygen indicated

• Grade 4 Bronchospasm, CTCAE|Grade 4 Bronchospasm

  life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated

• Grade 5 Bronchospasm, CTCAE|Grade 5 Bronchospasm

  death

• Toxic Polyneuropathy

  polyneuropathy that is caused by exposure to toxins.

• Desmoglein-3|130 kDa Pemphigus Vulgaris Antigen|Cadherin Family Member 6|DESMOGLEIN 3|DSG3|Desmoglein 3|PVA

  desmoglein-3 (999 aa, ~108 kda) is encoded by the human dsg3 gene. this protein plays a role in desmosome-mediated cell-cell adhesion.

• DSG3 Antibody Positive|Anti-DSG3 Antibody Positive|Anti-Desmoglein 3 Antibody Positive|Anti-Desmoglein-3 Antibody Positive|Anti-PVA Antibody Positive|CDHF6 Antibody Positive|Cadherin Family Member 6 Antibody Positive|Desmoglein 3 Antibody Positive|Desmoglein-3 Antibody Positive|PVA Antibody Positive|Pemphigus Vulgaris Antigen Antibody Positive

  an indication that antibodies that recognize desmoglein-3 (dsg3) have been detected in a sample.

• DSG3 wt Allele|ABOLM|CDHF6|Desmoglein 3 (Pemphigus Vulgaris Antigen) Gene|Desmoglein 3 wt Allele|PVA|Pemphigus Vulgaris Antigen Gene

  human dsg3 wild-type allele is located in the vicinity of 18q12.1 and is approximately 31 kb in length. this allele, which encodes desmoglein-3 protein, is involved in the modulation of cell-cell adhesion.

• Mucosal-Dominant Pemphigus Vulgaris|Mucosal Dominant Pemphigus Vulgaris|mPV

  a subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.

• Pemphigus Vulgaris

  an autoimmune blistering disorder. it is characterized by the presence of painful blisters and erosions in the skin and mucous membranes.

• Priapism

  persistent and usually painful erection that lasts for at least four hours in the absence of physical or psychological stimulation, which can be caused by hematologic disorders, including sickle cell disease and leukemia, spinal cord injuries, and medications.

• Acquired Central Hypothyroidism

  central hypothyroidism, the cause of which is not present at birth.

• Fixed Drug Eruption

  round areas of red-purple reaction in the skin that result after drug exposure; these recur in the same location when the medication is readministered.

• Onycholysis

  a nail condition characterized by spontaneous separation of a fingernail or toenail from its nail bed.

• Bullous Pemphigoid

  an autoimmune chronic skin disorder characterized by the presence of large blisters. it usually affects elderly people and tends to subside spontaneously.

• COL17A1 wt Allele|BA16H23.2|BA16H23.2 (Collagen, Type XVII, Alpha 1 (BP180)) Gene|BP180|BPA-2|BPAG2|Bullous Pemphigoid Antigen 2 (180kD) Gene|Collagen Type XVII Alpha 1 Chain wt Allele|Collagen, Type XVII, Alpha 1 Gene|Collagen, Type XVII, Alpha-1 Gene|ERED|LAD-1

  human col17a1 wild-type allele is located in the vicinity of 10q25.1 and is approximately 55 kb in length. this allele, which encodes collagen alpha-1(xvii) chain protein, is involved in hemidesmosome formation and keratinocyte adhesion. mutation of the gene and immunoreactivity during revertant mosaicism is associated with both generalized atrophic benign and junctional epidermolysis bullosa. mutations in the gene are also associated with epithelial recurrent erosion dystrophy.

• Collagen Alpha-1(XVII) Chain|180 kDa Bullous Pemphigoid Antigen 2|Alpha 1 Type XVII Collagen|Bullous Pemphigoid Antigen 2|COL17A1|Collagen Type XVII Alpha 1 Chain|Collagen Type XVII Alpha 1 Polypeptide|Type XVII Collagen Alpha-1

  collagen alpha-1(xvii) chain (1497 aa, ~150 kda) is encoded by the human col17a1 gene. this protein plays a role in the attachment of keratinocytes to the basement membrane.

• Dystonin|230 kDa Bullous Pemphigoid Antigen|230/240 kDa Bullous Pemphigoid Antigen|Bullous Pemphigoid Antigen|Bullous Pemphigoid Antigen 1|Bullous Pemphigoid Antigen 1, 230/240kDa|DST|Dystonia Musculorum Protein|Hemidesmosomal Plaque Protein|Trabeculin-Beta

  dystonin (7570 aa, ~860 kda) is encoded by the human dst gene. this protein plays a structural role in cytoskeleton networks.

• Pulmonary Toxicity

  toxicity that impairs or damages the lung(s). this condition is often caused by the administration of a pharmaceutical agent that causes damage to the lungs.

• Ototoxicity

  damage to the inner ear as a result of exposure to drugs or chemicals.

• Phototoxicity Study|PHOTOTOXICITY

  a study of the effect of an agent on the skin or eyes, such that it induces a sensitivity to sunlight or other forms of light.

• Phototoxicity|phototoxicity

  a nonimmunologic, chemically induced type of photosensitivity.

• Drug Induced Gingival Hyperplasia

  overgrowth of the gingival tissue caused by phenytoin, cyclosporine a, and calcium channel blockers.

• Pseudoporphyria

  a drug-induced photodermatosis characterized by skin fragility, erythema, and the appearance of tense bullae, erosions and scarring in the absence of abnormalities in porphyrin metabolism.

• Hyperkalemic Mineralocorticoid Resistance|Chloride Shunt Syndrome|Familial Hyperkalemic Hypertension|Gordon Hyperkalemia|Mineralocorticoid Resistant Hyperkalemia|PHA Type 2|Pseudohypoaldosteronism, Type II|Spitzer-Weinstein Syndrome

  a genetically heterogenous condition characterized by hyperkalemia, hyperchloremic acidosis, low or suppressed renin activity, and normal to high concentrations of aldosterone. mutations in genes (for example wnk1 or wnk4), regulating na-cl cotransporters (ncc), na-k-cl cotransporters (nkcc2), or the renal outer medullary potassium (romk) channel have been identified as causative in this condition. the primary abnormality is thought to be a specific defect of the renal secretory mechanism for potassium, which limits the kaliuretic response to, but not the sodium and chloride reabsorptive effect of, mineralocorticoid.

• Anetoderma

  a dermatologic condition characterized by focal loss of elastic tissue. clinically it presents with atrophic depressions or saccular outpouchings of the skin.

• Nail Loss, PRO-CTCAE|Nail loss|Onycholysis, PRO-CTCAE|PRO-CTCAE, Nail Loss

  onycholysis as recorded on the pro-ctcae questionnaire.

• Collagen Alpha-1(XVII) Chain|180 kDa Bullous Pemphigoid Antigen 2|Alpha 1 Type XVII Collagen|BASEMENT MEMBRANE ZONE BP180|BMZ BP180|BP180|BPAG2|Bullous Pemphigoid Antigen 2|Bullous Pemphigoid Antigen 2|COL17A1|Collagen Type XVII Alpha 1 Chain|Collagen Type XVII Alpha 1 Chain|Collagen Type XVII Alpha 1 Polypeptide|Type XVII Collagen Alpha-1

  collagen alpha-1(xvii) chain (1497 aa, ~150 kda) is encoded by the human col17a1 gene. this protein plays a role in the attachment of keratinocytes to the basement membrane.

• Dystonin|230 kDa Bullous Pemphigoid Antigen|230/240 kDa Bullous Pemphigoid Antigen|BASEMENT MEMBRANE ZONE BP230|BMZ BP230|BP230|BPAG1|Bullous Pemphigoid Antigen|Bullous Pemphigoid Antigen 1|Bullous Pemphigoid Antigen 1|Bullous Pemphigoid Antigen 1, 230/240kDa|DST|Dystonia Musculorum Protein|Hemidesmosomal Plaque Protein|Trabeculin-Beta

  dystonin (7570 aa, ~860 kda) is encoded by the human dst gene. this protein plays a structural role in cytoskeleton networks.

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Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

• What is a drug interaction?
• What are side effects?
• What are drug allergies?
• How can I stay safe when taking medicines?

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