2026 ICD-10-CM Diagnosis Code T50.7X4SPoisoning by analeptics and opioid receptor antagonists, undetermined, sequela
T50.7X4S is a billable ICD-10-CM diagnosis code for poisoning by analeptics and opioid receptor antagonists, undetermined, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T50.7X4S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Almitrine
a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. the drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. it may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.Bemegride
a cns stimulant that is used to induce convulsions in experimental animals. it has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.Cyclazocine
an analgesic with mixed narcotic agonist-antagonist properties.Doxapram
a central respiratory stimulant with a brief duration of action. (from martindale, the extra pharmocopoeia, 30th ed, p1225)Levallorphan
an opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. it should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (from martindale, the extra pharmacopoeia, 30th ed, p683)Lobeline
an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. it has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.Nalorphine
a narcotic antagonist with some agonist properties. it is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.Buprenorphine, Naloxone Drug Combination
a pharmaceutical preparation that combines buprenorphine, an opioid analgesics with naloxone, a narcotic antagonists to reduce the potential for narcotic dependence in the treatment of pain. it may also be used for opioid substitution therapy.Naloxone
a specific opiate antagonist that has no agonist activity. it is a competitive antagonist at mu, delta, and kappa opioid receptors.Naltrexone
derivative of noroxymorphone that is the n-cyclopropylmethyl congener of naloxone. it is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. the fda has approved naltrexone for the treatment of alcohol dependence.Nikethamide
a central nervous system stimulant. it was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (from martindale, the extra pharmacopoeia, 30th ed, p1229)Pemoline
a central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.Pentylenetetrazole
a pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. it is considered a non-competitive gamma-aminobutyric acid antagonist. pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.Picrotoxin
a mixture of picrotoxinin and picrotin that is a noncompetitive antagonist at gaba-a receptors acting as a convulsant. picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. although it is most often used as a research tool, it has been used as a cns stimulant and an antidote in poisoning by cns depressants, especially the barbiturates.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Poisoning
A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T50.7X4S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T50.7X4SOverview
Is T50.7X4S a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by analeptics and opioid receptor antagonists, undetermined, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T50.7X4S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by analeptics and opioid receptor antagonists, undetermined itself has resolved, not the original event.
What MS-DRG does T50.7X4S group to?
When poisoning by analeptics and opioid receptor antagonists, undetermined, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T50.7X4S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by analeptics and opioid receptor antagonists, undetermined, sequela on inpatient claims.
What is the ICD-9 equivalent of T50.7X4S?
Under the General Equivalence Mappings, poisoning by analeptics and opioid receptor antagonists, undetermined, sequela converts to ICD-9-CM 909.0 (late eff drug poisoning) and E989 (late eff inj-undet circ). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
