2026 ICD-10-CM Diagnosis Code T50.0X2SPoisoning by mineralocorticoids and their antagonists, intentional self-harm, sequela
T50.0X2S is a billable ICD-10-CM diagnosis code for poisoning by mineralocorticoids and their antagonists, intentional self-harm, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. Coders also document this condition as intentional deoxycortone poisoning. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders; sequela; and Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T50.0X2S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Intentional deoxycortone poisoning
- Intentional poisoning caused by corticosteroid and/or corticosteroid derivative
- Poisoning caused by deoxycortone
- Poisoning caused by mineralocorticoid agent
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances (T50). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Aldosterone
a hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Cytochrome P-450 CYP11B2
a mitochondrial cytochrome p450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and nadph-specific flavoprotein. this enzyme, encoded by cyp11b2 gene, is important in the conversion of corticosterone to 18-hydroxycorticosterone and the subsequent conversion to aldosterone.Mineralocorticoid Receptor Antagonists
drugs that bind to and block the activation of mineralocorticoid receptors by mineralocorticoids such as aldosterone.Receptors, Mineralocorticoid
cytoplasmic proteins that specifically bind mineralocorticoids and mediate their cellular effects. the receptor with its bound ligand acts in the nucleus to induce transcription of specific segments of dna.Canrenoic Acid
a synthetic pregnadiene derivative with anti-aldosterone activity.Canrenone
a synthetic pregnadiene compound with anti-aldosterone activity.Fludrocortisone
a synthetic mineralocorticoid with anti-inflammatory activity.Spironolactone
a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. it is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (from martindale, the extra pharmacopoeia, 30th ed, p827)
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Poisoning
A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T50.0X2S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T50.0X2SOverview
Is T50.0X2S a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by mineralocorticoids and their antagonists, intentional self-harm, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T50.0X2S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by mineralocorticoids and their antagonists, intentional self-harm itself has resolved, not the original event.
What MS-DRG does T50.0X2S group to?
When poisoning by mineralocorticoids and their antagonists, intentional self-harm, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T50.0X2S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by mineralocorticoids and their antagonists, intentional self-harm, sequela on inpatient claims.
What is the ICD-9 equivalent of T50.0X2S?
Under the General Equivalence Mappings, poisoning by mineralocorticoids and their antagonists, intentional self-harm, sequela converts to ICD-9-CM 909.0 (late eff drug poisoning) and E959 (late eff of self-injury). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
