2027 ICD-10-CM Diagnosis Code T49.6X5AAdverse effect of otorhinolaryngological drugs and preparations, initial encounter

ICD-10-CM T49.6X5A

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T49.6X5A is a billable ICD-10-CM diagnosis code for adverse effect of otorhinolaryngological drugs and preparations, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as adverse reaction caused by mouthwash. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code

T49.6X5A

Billable Status

Yes — Valid for Submission

Code Describes

Adverse effect of otorhinolaryngological drugs and preparations, initial encounter

Short Description

Adverse effect of otorhino drugs and preparations, init

Parent Code

T49.6X5

Adverse effect of otorhinolaryngological drugs and preparations

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes

SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

CategoryT49Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs

This CodeT49.6X5AAdverse effect of otorhinolaryngological drugs and preparations, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T49.6X5A.

Unacceptable principal diagnosis

There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

Adverse reaction caused by mouthwash
Adverse reaction to inhaled corticosteroids

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs (T49). Use the following options for the applicable episode of care:

A - initial encounter
D - subsequent encounter
S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T49.6X5A: its own notes plus those printed at T49, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From T49 Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs applies to 180 codes

poisoning by, adverse effect of and underdosing of glucocorticoids, topically used