2026 ICD-10-CM Diagnosis Code T49.3X5AAdverse effect of emollients, demulcents and protectants, initial encounter
T49.3X5A is a billable ICD-10-CM diagnosis code for adverse effect of emollients, demulcents and protectants, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T49.3X5A.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to aluminum and/or aluminum compound
- Adverse reaction to oil
- Antidotes for pesticides adverse reaction
- Arachis oil adverse reaction
- Aseptic peritonitis
- Bentonite powder adverse reaction
- Bilateral glaucoma caused by silicone oil
- Bilateral ocular hypertension caused by silicone oil
- Calamine adverse reaction
- Chemical peritonitis
- Collodion adverse reaction
- Contact dermatitis caused by hydrocarbon
- Disorder of retina caused by talc
- Emollient adverse reaction
- Emollient bath additives adverse reaction
- Fixed oil adverse reaction
- Glaucoma caused by silicone oil
- Glaucoma of left eye caused by silicone oil
- Glaucoma of right eye caused by silicone oil
- Irritant contact dermatitis caused by drug in contact with skin
- Irritant contact dermatitis caused by emollient substance
- Lanolin contact dermatitis
- Lipid granuloma of skin caused by mineral oil
- Lipogranuloma
- Ocular hypertension caused by silicone oil
- Ocular hypertension of left eye caused by silicone oil
- Ocular hypertension of right eye caused by silicone oil
- Oil contact dermatitis
- Paraffin adverse reaction
- Paraffinoma of skin
- Paraffin-white soft adverse reaction
- Paraffin-yellow soft adverse reaction
- Retinopathy of left eye caused by talc
- Retinopathy of right eye caused by talc
- Silicone adverse reaction
- Sunscreening preparations adverse reaction
- Talc peritonitis
- Wool alcohol adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs (T49). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Chemical Peritonitis
a non-infectious inflammation of the peritoneum.Erdheim-Chester Disease|ECD|Lipogranulomatosis|Polyostotic Sclerosing Histiocytosis
a very rare, multisystem non-langerhans cell histiocytosis that predominantly affects adults. it is characterized by the proliferation in the tissues of lipid-laden macrophages and the presence of multinucleated giant cells. it results in sclerosis of the long bones and failure of the affected organs. patients may present with bone pain, exophthalmos, ataxia, liver failure, kidney failure, and hypopituitarism.Farber Lipogranulomatosis
a very rare autosomal recessive metabolic disorder affecting lipid metabolism. it is caused by mutations in the asah1 gene and is characterized by fatty accumulation in the body tissues. patients develop lipogranulomas in the skin and internal organs, edema and pain in the joints and a hoarse voice. it may be associated with intellectual disability.Large Lipogranuloma Assessment|LPGNLMLG|Large Lipogranuloma|Large Lipogranuloma
an evaluation of the presence or degree of large lipogranuloma in a sample.Lipogranuloma
an inflammatory lesion comprised of lipoid material.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T49.3X5A to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T49.3X5AOverview
Is T49.3X5A (Adverse effect of emollients, demulcents and protectants) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of emollients, demulcents and protectants, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character A in T49.3X5A mean?
The final character A marks the initial encounter: use it while the patient is receiving active treatment for adverse effect of emollients, demulcents and protectants, such as an emergency visit or first evaluation.
What MS-DRG does T49.3X5A group to?
On inpatient claims, adverse effect of emollients, demulcents and protectants, initial encounter maps to MS-DRG 917, 918, with relative weights from 0.8571 to 1.5684 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T49.3X5A be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of emollients, demulcents and protectants, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
What is the ICD-9 equivalent of T49.3X5A?
Under the General Equivalence Mappings, adverse effect of emollients, demulcents and protectants, initial encounter converts to ICD-9-CM 995.29 (adv eff med/biol NEC/NOS) and E946.3 (adv eff emollient/demulc). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
