2027 ICD-10-CM Diagnosis Code T48.1X5SAdverse effect of skeletal muscle relaxants [neuromuscular blocking agents], sequela
T48.1X5S is a billable ICD-10-CM diagnosis code for adverse effect of skeletal muscle relaxants [neuromuscular blocking agents], sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T48.1X5S.
Present on Admission (POA)Billing
T48.1X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50).
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to central nervous system muscle-tone depressants
- Adverse reaction to ganglion blocking drug
- Adverse reaction to neuromuscular blocking agent
- Adverse reaction to skeletal muscle relaxants
- Alcuronium adverse reaction
- Atracurium adverse reaction
- Complication due to and following neuromuscular block
- Depolarizing muscle relaxant adverse reaction
- Drug-induced apnea
- Gallamine adverse reaction
- Methocarbamol adverse reaction
- Mivacurium adverse reaction
- Mivacurium apnea
- Muscle paresis due to and following neuromuscular blockade
- Non-depolarizing muscle relaxant adverse reaction
- Pain following administration of agent
- Pancuronium adverse reaction
- Rocuronium adverse reaction
- Suxamethonium adverse reaction
- Suxamethonium apnea
- Suxamethonium pains
- Tubocurarine adverse reaction
- Vecuronium adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (T48). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to T48.1X5S: its own notes plus those printed at T48, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify any retained foreign body, if applicable (Z18.-)
Notes
General instructions on how these codes are used.
- Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
- The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.
7th Character
Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.
- The appropriate 7th character is to be added to each code from category T48
- Ainitial encounter
- Dsubsequent encounter
- Ssequela this code
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Alcuronium
a non-depolarizing skeletal muscle relaxant similar to tubocurarine. it is used as an anesthesia adjuvant.Pancuronium
a bis-quaternary steroid that is a competitive nicotinic antagonist. as a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.Succinylcholine
a quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. it is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.Tubocurarine
a neuromuscular blocker and active ingredient in curare; plant based alkaloid of menispermaceae.Vecuronium Bromide
monoquaternary homolog of pancuronium. a non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T48.1X5S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T48.1X5SOverview
Is T48.1X5S a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of skeletal muscle relaxants [neuromuscular blocking agents], sequela on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What does the 7th character S in T48.1X5S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of skeletal muscle relaxants [neuromuscular blocking agents] itself has resolved, not the original event.
What MS-DRG does T48.1X5S group to?
On inpatient claims, adverse effect of skeletal muscle relaxants [neuromuscular blocking agents], sequela maps to MS-DRG 923, 922, with relative weights from 0.9980 to 1.6248 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T48.1X5S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of skeletal muscle relaxants [neuromuscular blocking agents], sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T48.1X5S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of skeletal muscle relaxants [neuromuscular blocking agents], sequela on inpatient claims. The code appears in the Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50) range of the CMS exempt list.
