2027 ICD-10-CM Diagnosis Code T47.6X5AAdverse effect of antidiarrheal drugs, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T47

ICD-10-CM T47.6X5A
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T47.6X5A is a billable ICD-10-CM diagnosis code for adverse effect of antidiarrheal drugs, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 791, 793, 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code
T47.6X5A
Billable Status
Yes — Valid for Submission
Code Describes
Adverse effect of antidiarrheal drugs, initial encounter
Short Description
Adverse effect of antidiarrheal drugs, initial encounter
Same as the full description in the CMS dataset.
Parent Code
Adverse effect of antidiarrheal drugs

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT47Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system
This CodeT47.6X5AAdverse effect of antidiarrheal drugs, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T47.6X5A.

There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adverse reaction to aluminum and/or aluminum compound
  • Adverse reaction to bismuth and/or bismuth compound
  • Adverse reaction to bismuth subnitrate and/or iodoform
  • Adverse reaction to diphenoxylate
  • Adverse reaction to pectin
  • Antidiarrheal drug adverse reaction
  • Charcoal activated adverse reaction
  • Kaolin adverse reaction
  • Loperamide adverse reaction
  • Non-melanin pigmentation caused by exogenous substance
  • Pigmentation caused by bismuth

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (T47). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T47.6X5A: its own notes plus those printed at T47.6, T47, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From T47.6 Poisoning by, adverse effect of and underdosing of antidiarrheal drugs applies to 18 codes
  • poisoning by, adverse effect of and underdosing of systemic antibiotics and other anti-infectives (T36-T37)
From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Code First

The underlying condition named in the note is sequenced before this code.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T47 Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system applies to 180 codes
  • The appropriate 7th character is to be added to each code from category T47
  • Ainitial encounter this code
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ028
Adverse effects of drugs and medicaments, initial encounter
Default principal diagnosis: inpatient No · outpatient Yes

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
Activated charcoal [See Also: Charcoal, medicinal]T47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Aluminium, aluminum::tannateT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
AmylopectinT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Antidiarrheal drug NECT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Antidiarrheal drug NEC::absorbentT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
AttapulgiteT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Bacillus::subtilisT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Bismuth saltsT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Bismuth salts::subcarbonateT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Carbo medicinalisT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
CharcoalT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Charcoal::activated [See Also: Charcoal, medicinal]T47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Charcoal::medicinal (activated)T47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Charcoal::medicinal (activated)::antidiarrhealT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
DifenoxinT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
DiphenoxylateT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
FetoxilateT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Intestinal motility control drugT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
KaolinT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Kaolin::lightT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Lactobacillus::acidophilusT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Lactobacillus::acidophilus::compoundT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Lactobacillus::bifidus, lyophilizedT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Lactobacillus::bulgaricusT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Lactobacillus::sporogenesT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Lignin hemicelluloseT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
LomotilT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
LoperamideT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Miyari bacteriaT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
PectinT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6
Saccharomyces boulardiiT47.6X1T47.6X2T47.6X3T47.6X4T47.6X5T47.6X6

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T47.6X5A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
995.29 Adv eff med/biol NEC/NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E943.5 Adv eff antidiarrhea agt
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T47.6X5AOverview

What is the ICD-10 code for adverse effect of antidiarrheal drugs, initial encounter?

The ICD-10-CM code for adverse effect of antidiarrheal drugs, initial encounter is T47.6X5A (sometimes written as T476X5A). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is T47.6X5A (Adverse effect of antidiarrheal drugs) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of antidiarrheal drugs, initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character A in T47.6X5A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for adverse effect of antidiarrheal drugs, such as an emergency visit or first evaluation.

What MS-DRG does T47.6X5A group to?

On inpatient claims, adverse effect of antidiarrheal drugs, initial encounter maps to MS-DRG 793, 791, 918, 917, with relative weights from 0.8716 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.

Can T47.6X5A be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of antidiarrheal drugs, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.