2026 ICD-10-CM Diagnosis Code T44.5X5AAdverse effect of predominantly beta-adrenoreceptor agonists, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T44

ICD-10-CM T44.5X5A
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

T44.5X5A is a billable ICD-10-CM diagnosis code for adverse effect of predominantly beta-adrenoreceptor agonists, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 917 through 918. The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Adverse effects of drugs and medicaments, initial encounter.

Code Identity

ICD-10-CM Code
T44.5X5A
Billable Status
Yes — Valid for Submission
Code Describes
Adverse effect of predominantly beta-adrenoreceptor agonists, initial encounter
Short Description
Adverse effect of predom beta-adrenocpt agonists, init
Parent Code
T44.5X5
Adverse effect of predominantly beta-adrenoreceptor agonists

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT44Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system
This CodeT44.5X5AAdverse effect of predominantly beta-adrenoreceptor agonists, initial encounter

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T44.5X5A.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adverse reaction to epinephrine
  • Beclomethasone adverse reaction
  • Beta-adrenoceptor agonist adverse reaction
  • Budesonide adverse reaction
  • Dobutamine adverse reaction
  • Dopexamine adverse reaction
  • Ritodrine adverse reaction
  • Selective beta-1 adrenoceptor stimulants adverse reaction
  • Selective beta-2 adrenoceptor stimulants adverse reaction
  • Topical budesonide adverse reaction
  • Xamoterol adverse reaction

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (T44). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ028
Adverse effects of drugs and medicaments, initial encounter
Default principal diagnosis: inpatient No · outpatient Yes

Clinical InformationClinical

  • Beclomethasone

    an anti-inflammatory, synthetic glucocorticoid. it is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.

  • Budesonide

    a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis.

  • Budesonide, Formoterol Fumarate Drug Combination

    a pharmaceutical preparation of budesonide and formoterol fumarate that is used as an anti-asthmatic agent and for the treatment of chronic obstructive pulmonary disease.

  • Dobutamine

    a catecholamine derivative with specificity for beta-1 adrenergic receptors. it is commonly used as a cardiotonic agent after cardiac surgery and during dobutamine stress echocardiography.

  • Echocardiography, Stress

    a method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (exercise test) or pharmacologic stress.

  • Epinephrine

    the active sympathomimetic hormone from the adrenal medulla. it stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. it is used in asthma and cardiac failure and to delay absorption of local anesthetics.

  • Racepinephrine

    a racemic mixture of d-epinephrine and l-epinephrine.

  • Receptors, Adrenergic

    cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. the two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. adrenergic receptors may also be classified according to the subtypes of g-proteins with which they bind; this scheme does not respect the alpha-beta distinction.

  • Isoetharine

    adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.

  • Prenalterol

    a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. it is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output syndrome, shock, and reducing orthostatic hypotension in the shy-rager syndrome.

  • Procaterol

    a long-acting beta-2-adrenergic receptor agonist.

  • Ritodrine

    an adrenergic beta-2 agonist used to control premature labor.

  • Xamoterol

    a phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect		Under­dosing
AdrenalineT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
AngiotensinT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
BeclomethasoneT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
BudesonideT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
DobutamineT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
EpinephrineT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
IsoetharineT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
PrenalterolT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
ProcaterolT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
RacepinefrinT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
RitodrineT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6
XamoterolT44.5X1T44.5X2T44.5X3T44.5X4T44.5X5T44.5X6

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T44.5X5A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
995.29 Adv eff med/biol NEC/NOS
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E941.2 Adv eff sympathomimetics
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About T44.5X5AOverview

Is T44.5X5A (Adverse effect of predominantly beta-adrenoreceptor agonists) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of predominantly beta-adrenoreceptor agonists, initial encounter on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What does the 7th character A in T44.5X5A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for adverse effect of predominantly beta-adrenoreceptor agonists, such as an emergency visit or first evaluation.

What MS-DRG does T44.5X5A group to?

On inpatient claims, adverse effect of predominantly beta-adrenoreceptor agonists, initial encounter maps to MS-DRG 917, 918, with relative weights from 0.8571 to 1.5684 depending on complications. Higher weights mean higher Medicare reimbursement.

Can T44.5X5A be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of predominantly beta-adrenoreceptor agonists, initial encounter describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

What is the ICD-9 equivalent of T44.5X5A?

Under the General Equivalence Mappings, adverse effect of predominantly beta-adrenoreceptor agonists, initial encounter converts to ICD-9-CM 995.29 (adv eff med/biol NEC/NOS) and E941.2 (adv eff sympathomimetics). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.