2026 ICD-10-CM Diagnosis Code T44.0X5SAdverse effect of anticholinesterase agents, sequela
T44.0X5S is a billable ICD-10-CM diagnosis code for adverse effect of anticholinesterase agents, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as anticholinesterase parasympathomimetic adverse reaction. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T44.0X5S.
Present on Admission (POA)Billing
T44.0X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anticholinesterase parasympathomimetic adverse reaction
- Distigmine adverse reaction
- Edrophonium adverse reaction
- Neostigmine adverse reaction
- Pyridostigmine adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (T44). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Edrophonium
a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. it has also been used as an antidote to curare principles.Galantamine
a benzazepine derived from norbelladine. it is found in galanthus and other amaryllidaceae. it is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine and has been studied as a treatment for alzheimer disease and other central nervous system disorders.Isoflurophate
a di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the nervous system.Pyridostigmine Bromide
a cholinesterase inhibitor with a slightly longer duration of action than neostigmine. it is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.Tacrine
a cholinesterase inhibitor that crosses the blood-brain barrier. tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of alzheimer's disease and other central nervous system disorders.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T44.0X5S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T44.0X5SOverview
Is T44.0X5S (Adverse effect of anticholinesterase agents) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of anticholinesterase agents, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T44.0X5S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of anticholinesterase agents itself has resolved, not the original event.
What MS-DRG does T44.0X5S group to?
On inpatient claims, adverse effect of anticholinesterase agents, sequela maps to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T44.0X5S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of anticholinesterase agents, sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T44.0X5S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of anticholinesterase agents, sequela on inpatient claims.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
