2026 ICD-10-CM Diagnosis Code T43.4X1SPoisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional), sequela
T43.4X1S is a billable ICD-10-CM diagnosis code for poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional), sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T43.4X1S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Accidental benperidol overdose
- Accidental benperidol poisoning
- Accidental chlorprothixene overdose
- Accidental chlorprothixene poisoning
- Accidental flupenthixol decanoate overdose
- Accidental flupenthixol decanoate poisoning
- Accidental flupenthixol overdose
- Accidental flupenthixol poisoning
- Accidental haloperidol overdose
- Accidental poisoning by butyrophenone-based tranquilizer
- Accidental poisoning by haloperidol
- Accidental poisoning by spiperone
- Accidental poisoning by trifluperidol
- Accidental trifluperidol overdose
- Accidental zuclopenthixol decanoate overdose
- Accidental zuclopenthixol decanoate poisoning
- Accidental zuclopenthixol poisoning
- Benperidol overdose
- Benperidol poisoning
- Butyrophenone overdose
- Chlorprothixene overdose
- Chlorprothixene poisoning
- Flupenthixol decanoate overdose
- Flupenthixol decanoate poisoning
- Flupenthixol overdose
- Flupenthixol poisoning
- Haloperidol overdose
- Poisoning by butyrophenone-based tranquilizer
- Poisoning by haloperidol
- Poisoning by trifluperidol
- Spiperone poisoning
- Trifluperidol overdose
- Zuclopenthixol decanoate overdose
- Zuclopenthixol decanoate poisoning
- Zuclopenthixol poisoning
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (T43). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Benperidol
a butyrophenone with general properties similar to those of haloperidol. it has been used in the treatment of aberrant sexual behavior. (from martindale, the extra pharmacopoeia, 30th ed, p567)Chlorprothixene
a thioxanthine with effects similar to the phenothiazine antipsychotics.Clopenthixol
a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. it is an antagonist at d1 and d2 dopamine receptors.Flupenthixol
a thioxanthene neuroleptic that, unlike chlorpromazine, is claimed to have cns-activating properties. it is used in the treatment of psychoses although not in excited or manic patients. (from martindale, the extra pharmacopoeia, 30th ed, p595)Haloperidol
a phenyl-piperidinyl-butyrophenone that is used primarily to treat schizophrenia and other psychoses. it is also used in schizoaffective disorder, delusional disorders, ballism, and tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in intellectual disability and the chorea of huntington disease. it is a potent antiemetic and is used in the treatment of intractable hiccups. (from ama drug evaluations annual, 1994, p279)Spiperone
a spiro butyrophenone analog similar to haloperidol and other related compounds. it has been recommended in the treatment of schizophrenia.Thiothixene
a thioxanthine used as an antipsychotic agent. its effects are similar to the phenothiazine antipsychotics.Trifluperidol
a butyrophenone with general properties similar to those of haloperidol. it is used in the treatment of psychoses including mania and schizophrenia. (from martindale, the extra pharmacopoeia, 30th ed, p621)
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Medication Errors
Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T43.4X1S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T43.4X1SOverview
Is T43.4X1S a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional), sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T43.4X1S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional) itself has resolved, not the original event.
What MS-DRG does T43.4X1S group to?
When poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional), sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T43.4X1S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional), sequela on inpatient claims.
What is the ICD-9 equivalent of T43.4X1S?
Under the General Equivalence Mappings, poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional), sequela converts to ICD-9-CM 909.0 (late eff drug poisoning) and E929.2 (late eff acc poisoning). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
