2027 ICD-10-CM Diagnosis Code T43.015SAdverse effect of tricyclic antidepressants, sequela

ICD-10-CM T43.015S

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T43.015S is a billable ICD-10-CM diagnosis code for adverse effect of tricyclic antidepressants, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.

Code Identity

ICD-10-CM Code

T43.015S

Billable Status

Yes — Valid for Submission

Code Describes

Adverse effect of tricyclic antidepressants, sequela

Short Description

Adverse effect of tricyclic antidepressants, sequela

Same as the full description in the CMS dataset.

Parent Code

T43.015

Adverse effect of tricyclic antidepressants

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes

SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

CategoryT43Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified

This CodeT43.015SAdverse effect of tricyclic antidepressants, sequela

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T43.015S.

Unacceptable principal diagnosis

There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

T43.015S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

Amitriptyline adverse reaction
Amoxapine adverse reaction
Butriptyline adverse reaction
Clomipramine adverse reaction
Desipramine adverse reaction
Dosulepin adverse reaction
Doxepin adverse reaction
Imipramine adverse reaction
Iprindole adverse reaction
Lofepramine adverse reaction
Nortriptyline adverse reaction
Protriptyline adverse reaction
Tricyclic antidepressant drug adverse reaction
Trimipramine adverse reaction

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (T43). Use the following options for the applicable episode of care:

A - initial encounter
D - subsequent encounter
S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T43.015S: its own notes plus those printed at T43, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.