2026 ICD-10-CM Diagnosis Code T42.74XSPoisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined, sequela
T42.74XS is a billable ICD-10-CM diagnosis code for poisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders; sequela; and Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T42.74XS is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (T42). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
AIDS Arteritis, Central Nervous System
inflammation of arteries in the central nervous system that occurs in patients with acquired immunodeficiency syndrome or aids-related opportunistic infections.Brain Diseases
pathologic conditions affecting the brain, which is composed of the intracranial components of the central nervous system. this includes (but is not limited to) the cerebral cortex; intracranial white matter; basal ganglia; thalamus; hypothalamus; brain stem; and cerebellum.Brain Diseases, Metabolic
acquired or inborn metabolic diseases that produce brain dysfunction or damage. these include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.Brain Diseases, Metabolic, Inborn
brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. the majority of these conditions are familial, however spontaneous mutation may also occur in utero.Central Nervous System
the main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Central Nervous System Agents
a class of drugs producing both physiological and psychological effects through a variety of mechanisms. they can be divided into specific agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and nonspecific agents, those producing effects on different target cells and acting by diverse molecular mechanisms. those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. those with specific mechanisms are classed by locus of action or specific therapeutic use. (from gilman ag, et al., goodman and gilman's the pharmacological basis of therapeutics, 8th ed, p252)Central Nervous System Bacterial Infections
bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.Central Nervous System Cysts
congenital or acquired cysts of the brain, spinal cord, or meninges which may remain stable in size or undergo progressive enlargement.Central Nervous System Depressants
a very loosely defined group of drugs that tend to reduce the activity of the central nervous system. the major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).Central Nervous System Diseases
diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.Central Nervous System Fungal Infections
mycoses of the brain, spinal cord, and meninges which may result in encephalitis; meningitis, fungal; myelitis; brain abscess; and epidural abscess. certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., acquired immunodeficiency syndrome).Central Nervous System Helminthiasis
infections of the brain; spinal cord; or meninges caused by helminths (parasitic worms).Central Nervous System Infections
pathogenic infections of the brain, spinal cord, and meninges. dna virus infections; rna virus infections; bacterial infections; mycoplasma infections; spirochaetales infections; fungal infections; protozoan infections; helminthiasis; and prion diseases may involve the central nervous system as a primary or secondary process.Central Nervous System Neoplasms
benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Central Nervous System Parasitic Infections
infections of the brain, spinal cord, and meninges caused by parasites.Central Nervous System Protozoal Infections
infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. the central nervous system may be the primary or secondary site of protozoal infection. these diseases may occur as opportunistic infections or arise in immunocompetent hosts.Central Nervous System Sensitization
an increased response to stimulation that is mediated by amplification of signaling in the central nervous system (cns).Central Nervous System Stimulants
a loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. they work by a variety of mechanisms, but usually not by direct excitation of neurons. the many drugs that have such actions as side effects to their main therapeutic use are not included here.Central Nervous System Vascular Malformations
congenital, inherited, or acquired abnormalities involving arteries; veins; or venous sinuses in the brain; spinal cord; and meninges.Central Nervous System Venous Angioma
a vascular anomaly characterized by a radial or wedge-shaped arrangement of dilated veins draining into a larger vein in the brain, spinal cord, or the meninges. veins in a venous angioma are surrounded by normal nervous tissue, unlike a central nervous system cavernous hemangioma that lacks intervening nervous tissue. drainage of venous angioma is fully integrated with the body's venous system, therefore, in most cases there is no clinical signs and rare bleeding.Central Nervous System Viral Diseases
viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.Cerebral Phaeohyphomycosis
cns infections caused by neurotropic dematiaceous fungi that contain melanin in their cell walls. the infections often result in brain abscess; encephalitis; and meningitis in patients who are often immunocompetent. the common causative fungi include members cladophialophora bantiana, exophiala dermatitidis, rhinocladiella mackenziei, and ochroconis gallopavum. r. mackenziei infection is seen almost exclusively in patients from the middle east.Coccidioidal Meningitis
meningitis caused by a fungus of the genus coccidioides, endemic to the southwestern united states, south-central washington state, and parts of mexico and central and south america.Hemangioma, Cavernous, Central Nervous System
a vascular anomaly composed of a collection of large, thin walled tortuous veins that can occur in any part of the central nervous system but lack intervening nervous tissue. familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. clinical features include seizures; headache; stroke; and progressive neurological deficit.Hereditary Central Nervous System Demyelinating Diseases
inherited conditions characterized by a loss of myelin in the central nervous system.Lupus Vasculitis, Central Nervous System
central nervous system vasculitis that is associated with systemic lupus erythematosus. clinical manifestations may include dementia; seizures; cranial nerve diseases; hemiparesis; blindness; dysphasia; and other neurological disorders.Lyme Neuroborreliosis
nervous system infections caused by tick-borne spirochetes of the borrelia burgdorferi group. the disease may affect elements of the central or peripheral nervous system in isolation or in combination. common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), polyradiculopathy, and a mild loss of memory and other cognitive functions. less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. in the peripheral nervous system, b. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (from j neurol sci 1998 jan 8;153(2):182-91)Neurocysticercosis
infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus taenia (primarily t. solium in humans). lesions formed by the organism are referred to as cysticerci. the infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. seizures represent the most common clinical manifestation although focal neurologic deficits may occur. (from joynt, clinical neurology, 1998, ch27, pp46-50)Neuroschistosomiasis
schistosomiasis of the brain, spinal cord, or meninges caused by infections with trematodes of the genus schistosoma (primarily schistosoma japonicum; schistosoma mansoni; and schistosoma haematobium in humans). s. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. s. mansoni and s. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (from joynt, clinical neurology, 1998, ch27, pp61-2)Neurosyphilis
infections of the central nervous system caused by treponema pallidum which present with a variety of clinical syndromes. the initial phase of infection usually causes a mild or asymptomatic meningeal reaction. the meningovascular form may present acutely as brain infarction. the infection may also remain subclinical for several years. late syndromes include general paresis; tabes dorsalis; meningeal syphilis; syphilitic optic atrophy; and spinal syphilis. general paresis is characterized by progressive dementia; dysarthria; tremor; myoclonus; seizures; and argyll-robertson pupils. (adams et al., principles of neurology, 6th ed, pp722-8)Toxoplasmosis, Cerebral
infections of the brain caused by the protozoan toxoplasma gondii that primarily arise in individuals with immunologic deficiency syndromes (see also aids-related opportunistic infections). the infection may involve the brain diffusely or form discrete abscesses. clinical manifestations include seizures, altered mentation, headache, focal neurologic deficits, and intracranial hypertension. (from joynt, clinical neurology, 1998, ch27, pp41-3)Tuberculosis, Central Nervous System
tuberculosis of the brain, spinal cord, or meninges (tuberculosis, meningeal), most often caused by mycobacterium tuberculosis and rarely by mycobacterium bovis. the infection may be limited to the nervous system or coexist in other organs (e.g., tuberculosis, pulmonary). the organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of tuberculoma, which may occur within the brain, spinal cord, or perimeningeal spaces. tuberculous involvement of the vertebral column (tuberculosis, spinal) may result in nerve root or spinal cord compression. (from adams et al., principles of neurology, 6th ed, pp717-20)Vasculitis, Central Nervous System
inflammation of blood vessels within the central nervous system. primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. clinical manifestations are highly variable but include headache; seizures; behavioral alterations; intracranial hemorrhages; transient ischemic attack; and brain infarction. (from adams et al., principles of neurology, 6th ed, pp856-61)Vertigo
an illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. vertigo may be associated with disorders of the inner ear (ear, inner); vestibular nerve; brainstem; or cerebral cortex. lesions in the temporal lobe and parietal lobe may be associated with focal seizures that may feature vertigo as an ictal manifestation. (from adams et al., principles of neurology, 6th ed, pp300-1)
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
| Substance | Accidental | Self-harm | Assault | Undetermined | Adverse Effect | Underdosing |
|---|---|---|---|---|---|---|
| Anticonvulsant | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::barbiturate | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::combination (with barbiturate) | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::hydantoin | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::hypnotic NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::oxazolidinedione | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::pyrimidinedione | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::specified NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Anticonvulsant::succinimide | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Antiepilepsy agent | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Antiepilepsy agent::combination | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Antiepilepsy agent::mixed | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Antiepilepsy agent::specified, NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::anesthetic (general) NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::anesthetic (general) NEC::gases NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::anesthetic (general) NEC::intravenous | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::barbiturates | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::benzodiazepines | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::bromides | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::cannabis sativa | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::chloral hydrate | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::ethanol | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::hallucinogenics | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::hypnotics | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::hypnotics::specified NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::muscle relaxants | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::paraldehyde | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::sedatives; sedative-hypnotics | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::sedatives; sedative-hypnotics::mixed NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::depressants::sedatives; sedative-hypnotics::specified NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::muscle-tone depressants | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::stimulants | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::stimulants::amphetamines | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::stimulants::analeptics | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::stimulants::antidepressants | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::stimulants::opiate antagonists | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Central nervous system::stimulants::specified NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Hypnotic | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Hypnotic::anticonvulsant | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Hypnotic::specified NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Sedative NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Sedative NEC::mixed NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Sleeping draught, pill | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Soporific | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Soporific drug | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
| Soporific drug::specified type NEC | T42.71 | T42.72 | T42.73 | T42.74 | T42.75 | T42.76 |
Patient EducationClinical
Poisoning
A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T42.74XS to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T42.74XSOverview
Is T42.74XS a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T42.74XS mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined itself has resolved, not the original event.
What MS-DRG does T42.74XS group to?
When poisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T42.74XS exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined, sequela on inpatient claims.
What is the ICD-9 equivalent of T42.74XS?
Under the General Equivalence Mappings, poisoning by unspecified antiepileptic and sedative-hypnotic drugs, undetermined, sequela converts to ICD-9-CM 909.0 (late eff drug poisoning) and E989 (late eff inj-undet circ). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
