2027 ICD-10-CM Diagnosis Code T42.0X5SAdverse effect of hydantoin derivatives, sequela

ICD-10-CM T42.0X5S

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T42.0X5S is a billable ICD-10-CM diagnosis code for adverse effect of hydantoin derivatives, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.

Code Identity

ICD-10-CM Code

T42.0X5S

Billable Status

Yes — Valid for Submission

Code Describes

Adverse effect of hydantoin derivatives, sequela

Short Description

Adverse effect of hydantoin derivatives, sequela

Same as the full description in the CMS dataset.

Parent Code

T42.0X5

Adverse effect of hydantoin derivatives

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes

SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

CategoryT42Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs

This CodeT42.0X5SAdverse effect of hydantoin derivatives, sequela

Code EditsBilling

Medicare Code Editor checks that affect claim validity for T42.0X5S.

Unacceptable principal diagnosis

There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

T42.0X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

Adverse reaction to hydantoin and/or hydantoin derivative
Class I antiarrhythmic adverse reaction
Drug-induced erythema multiforme
Drug-induced lupus erythematosus
Drug-induced lupus erythematosus caused by diphenylhydantoin
EMPACT syndrome
Gingival disease caused by drug
Gingival hypertrophy caused by diphenylhydantoin
Hypertrophy of gingiva
Phenytoin adverse reaction
Purple glove syndrome

Coding GuidelinesGuidance

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (T42). Use the following options for the applicable episode of care:

A - initial encounter
D - subsequent encounter
S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T42.0X5S: its own notes plus those printed at T42, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.