2027 ICD-10-CM Diagnosis Code T42.0X2SPoisoning by hydantoin derivatives, intentional self-harm, sequela

ICD-10-CM Codes›S00–T88›T36-T50›T42

ICD-10-CM T42.0X2S
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T42.0X2S is a billable ICD-10-CM diagnosis code for poisoning by hydantoin derivatives, intentional self-harm, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. Coders also document this condition as hydantoin derivative poisoning. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders; sequela; and Poisoning/toxic effect/adverse effects/underdosing, sequela.

T42.0X2S no longer risk-adjusts for Medicare Advantage: it mapped to HCC 59 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 58, ESRD (V21) category 58, and ESRD (V24) category 59 for payment year 2027.

Code Identity

ICD-10-CM Code
T42.0X2S
Billable Status
Yes — Valid for Submission
Code Describes
Poisoning by hydantoin derivatives, intentional self-harm, sequela
Short Description
Poisoning by hydantoin derivatives, self-harm, sequela
Parent Code
Poisoning by hydantoin derivatives, intentional self-harm

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT42Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs
This CodeT42.0X2SPoisoning by hydantoin derivatives, intentional self-harm, sequela

Present on Admission (POA)Billing

Medicare Risk Adjustment (HCC)Billing

T42.0X2S no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 59
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 58 · ESRD (V21): HCC 58 · ESRD (V24): HCC 59
ESRD V21 weights: 0.091 dialysis, 0.217–0.260 functioning graft · ESRD V24 weights: 0.066 dialysis, 0.129–0.259 functioning graft
Part D (RxHCC)
Not mapped
T42.0X2S does not risk-adjust in the RxHCC prescription drug model

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hydantoin derivative poisoning
  • Intentional phenytoin overdose
  • Intentional phenytoin poisoning
  • Phenytoin overdose
  • Poisoning by phenytoin

Coding GuidelinesGuidance

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (T42). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T42.0X2S: its own notes plus those printed at T42, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From T42 Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs applies to 162 codes
  • drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.--F19.-)
From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Code First

The underlying condition named in the note is sequenced before this code.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T42 Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs applies to 162 codes
  • The appropriate 7th character is to be added to each code from category T42
  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela this code

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T42.0X2S, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming T42.0X2S: its condition is not part of those codes, and both may be reported when the patient has both.

  • F13.2 Sedative, hypnotic or anxiolytic-related dependence
    sedative, hypnotic, or anxiolytic poisoning (T42.-) names T42.-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD034
Mental and substance use disorders; sequela
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR INJ075
Poisoning/toxic effect/adverse effects/underdosing, sequela
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Mephenytoin

    an anticonvulsant effective in tonic-clonic epilepsy (epilepsy, tonic-clonic). it may cause blood dyscrasias.
  • Phenytoin

    an anticonvulsant that is used to treat a wide variety of seizures. it is also an anti-arrhythmic and a muscle relaxant. the mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. the mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
AlbutoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
Anticonvulsant::hydantoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
DilantinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
DiphenylhydantoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
EpanutinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
EthotoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
Hydantoin derivative NECT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
MephenytoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
MetetoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
MethetoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
MethoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
PhenantoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6
PhenytoinT42.0X1T42.0X2T42.0X3T42.0X4T42.0X5T42.0X6

Patient EducationClinical

Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T42.0X2S to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
909.0 Late eff drug poisoning
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E959 Late eff of self-injury
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T42.0X2SOverview

What is the ICD-10 code for poisoning by hydantoin derivatives, intentional self-harm, sequela?

The ICD-10-CM code for poisoning by hydantoin derivatives, intentional self-harm, sequela is T42.0X2S (sometimes written as T420X2S). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is T42.0X2S (Poisoning by hydantoin derivatives, intentional self-harm) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by hydantoin derivatives, intentional self-harm, sequela on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character S in T42.0X2S mean?

The final character S makes this a sequela code: it reports a lingering problem that remains after the poisoning by hydantoin derivatives, intentional self-harm itself has resolved, not the original event.

What MS-DRG does T42.0X2S group to?

When poisoning by hydantoin derivatives, intentional self-harm, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 923, 922, with relative weights from 0.9980 to 1.6248 depending on complications. Higher weights mean higher Medicare reimbursement.

Is T42.0X2S exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for poisoning by hydantoin derivatives, intentional self-harm, sequela on inpatient claims. The code appears in the Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50) range of the CMS exempt list.

Does T42.0X2S risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. T42.0X2S mapped to HCC 59 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 58 (Major Depressive/Bipolar/and Paranoid Disorders), ESRD (V21) category 58 (Major Depressive/Bipolar/and Paranoid Disorders), and ESRD (V24) category 59 (Major Depressive/Bipolar/and Paranoid Disorders).