2026 ICD-10-CM Diagnosis Code T41.3X5SAdverse effect of local anesthetics, sequela
T41.3X5S is a billable ICD-10-CM diagnosis code for adverse effect of local anesthetics, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Poisoning/toxic effect/adverse effects/underdosing, sequela.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for T41.3X5S.
Present on Admission (POA)Billing
T41.3X5S is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adverse reaction to peripheral nerve and plexus blocking anesthetic
- Adverse reaction to spinal anesthetic
- Adverse reaction to surface and infiltration anesthetic
- Adverse reaction to tetracaine
- Benzocaine adverse reaction
- Bupivacaine adverse reaction
- Cinchocaine adverse reaction
- Class I antiarrhythmic adverse reaction
- Lidocaine adverse reaction
- Local anesthetic drug adverse reaction
- Mechanical strabismus due to disorder of skeletal muscle caused by local anesthetic
- Myopathy caused by local anesthetic
- Oxybuprocaine adverse reaction
- Prilocaine adverse reaction
- Procaine adverse reaction
- Proxymetacaine adverse reaction
Coding GuidelinesGuidance
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (T41). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acupuncture Analgesia
analgesia produced by the insertion of acupuncture needles at certain acupuncture points on the body. this activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.Adjuvants, Anesthesia
agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.Anesthesia
a state characterized by loss of feeling or sensation. this depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.Anesthesia and Analgesia
medical methods of either relieving pain caused by a particular condition or removing the sensation of pain during a surgery or other medical procedure.Anesthesia Department, Hospital
hospital department responsible for the administration of functions and activities pertaining to the delivery of anesthetics.Anesthesia Recovery Period
the period of emergence from general anesthesia, where different elements of consciousness return at different rates.Anesthesia, Cardiac Procedures
a range of methods used to induce unconsciousness; analgesia; and muscle relaxation during cardiac procedures.Anesthesia, Caudal
epidural anesthesia administered via the sacral canal.Anesthesia, Closed-Circuit
inhalation anesthesia where the gases exhaled by the patient are rebreathed as some carbon dioxide is simultaneously removed and anesthetic gas and oxygen are added so that no anesthetic escapes into the room. closed-circuit anesthesia is used especially with explosive anesthetics to prevent fires where electrical sparking from instruments is possible.Anesthesia, Conduction
injection of an anesthetic to inhibit nerve transmission in a specific part of the body.Anesthesia, Dental
a range of methods used to reduce pain and anxiety during dental procedures.Anesthesia, Endotracheal
procedure in which an anesthetic such as a gas or mixture of gases is inhaled through a tube into the lungs.Anesthesia, Epidural
procedure in which an anesthetic is injected into the epidural space.Anesthesia, General
procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.Anesthesia, Inhalation
anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.Anesthesia, Intravenous
process of administering an anesthetic through injection directly into the bloodstream.Anesthesia, Local
a blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Anesthesia, Obstetrical
a variety of anesthetic methods such as epidural anesthesia used to control the pain of childbirth.Anesthesia, Rectal
procedure involving the instillation of an anesthetic into the rectum.Anesthesia, Spinal
procedure in which an anesthetic is injected directly into the spinal cord.Anesthetists
persons trained and certified to administer anesthetics.Balanced Anesthesia
the use of several anesthetics together in small amounts, as opposed to a larger amount of one drug, to induce loss of sensation and loss of consciousness.Brachial Plexus Block
a blocking of neural conduction in the network of nerve fibers innervating the upper extremity.Cervical Plexus Block
a blocking of neural conduction in the network of nerve fibers innervating the neck and shoulder.Cryoanesthesia
anesthesia achieved by lowering either body temperature (core cooling) or skin temperature (external cooling).Electronarcosis
profound stupor produced by passing an electric current through the brain.Emergence Delirium
a form of delirium which occurs after general anesthesia.Geriatric Anesthesia
conducting anesthesia procedures in aged adults, typically those aged 65 years and older.Intraoperative Awareness
occurence of a patient becoming conscious during a procedure performed under general anesthesia and subsequently having recall of these events. (from anesthesiology 2006, 104(4): 847-64.)Malignant Hyperthermia
rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.Neuroanesthesia
anesthesia method that deals with the complexities of the physiology and pharmacology of the nervous system when providing anesthesia for patients undergoing neurological procedures.Onco-anesthesia
methods used by specialized onco-anesthesiologists in the perioperative care of patients undergoing cancer-related diagnostic and therapeutic procedures. the aim is to minimize preoperative complications, expedite recovery, and facilitate early return to intended oncological treatment.Pediatric Anesthesia
conducting anesthesia procedures in infants, children, and adolescents.Treatment Refusal
patient or client refusal of or resistance to medical, psychological, or psychiatric treatment. (apa, thesaurus of psychological index terms, 8th ed.)Benzocaine
a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.Bupivacaine
a widely used local anesthetic agent.Dibucaine
a local anesthetic of the amide type now generally used for surface anesthesia. it is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (from martindale, the extra pharmacopoeia, 30th ed, p1006)Etidocaine
a local anesthetic with rapid onset and long action, similar to bupivacaine.Lidocaine
a local anesthetic and cardiac depressant used as an antiarrhythmia agent. its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.Lidocaine, Prilocaine Drug Combination
a topical local anesthetic preparation that is composed of a mixture of lidocaine and prilocaine. it is used to provide anesthesia during minor surgery and for the treatment of premature ejaculation.Mepivacaine
a local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. it is indicated for infiltration, nerve block, and epidural anesthesia. mepivacaine is effective topically only in large doses and therefore should not be used by this route. (from ama drug evaluations, 1994, p168)Prilocaine
a local anesthetic that is similar pharmacologically to lidocaine. currently, it is used most often for infiltration anesthesia in dentistry.Carboxylesterase
carboxylesterase is a serine-dependent esterase with wide substrate specificity. the enzyme is involved in the detoxification of xenobiotics and the activation of ester and of amide prodrugs.Penicillin G Procaine
semisynthetic antibiotic prepared by combining penicillin g with procaine.Procainamide
a class ia antiarrhythmic drug that is structurally-related to procaine.Procaine
a local anesthetic of the ester type that has a slow onset and a short duration of action. it is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (from martindale, the extra pharmacopoeia, 30th ed, p1016).Propoxycaine
a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (from martindale, the extra pharmacopoeia, 30th ed, p1017)Tetracaine
a potent local anesthetic of the ester type used for surface and spinal anesthesia.Trimecaine
acetanilide derivative used as a local anesthetic.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Drug Reactions
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Convert T41.3X5S to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T41.3X5SOverview
Is T41.3X5S (Adverse effect of local anesthetics) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report adverse effect of local anesthetics, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T41.3X5S mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the adverse effect of local anesthetics itself has resolved, not the original event.
What MS-DRG does T41.3X5S group to?
On inpatient claims, adverse effect of local anesthetics, sequela maps to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T41.3X5S be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because adverse effect of local anesthetics, sequela describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is T41.3X5S exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for adverse effect of local anesthetics, sequela on inpatient claims.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
