2027 ICD-10-CM Diagnosis Code T37.2X4APoisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter

ICD-10-CM Codes›S00–T88›T36-T50›T37

ICD-10-CM T37.2X4A
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T37.2X4A is a billable ICD-10-CM diagnosis code for poisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 917 through 918. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under External cause codes: intent of injury, undetermined; External cause codes: poisoning by drug; and Poisoning by drugs, initial encounter.

Code Identity

ICD-10-CM Code
T37.2X4A
Billable Status
Yes — Valid for Submission
Code Describes
Poisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter
Short Description
Poisn by antimalari/drugs acting on bld protzoa, undet, init
Parent Code
Poisoning by antimalarials and drugs acting on other blood protozoa, undetermined

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT36-T50Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
CategoryT37Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics
This CodeT37.2X4APoisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter

Coding GuidelinesGuidance

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (T37). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T37.2X4A: its own notes plus those printed at T37.2, T37, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From T37.2 Poisoning by, adverse effect of and underdosing of antimalarials and drugs acting on other blood protozoa applies to 18 codes
  • hydroxyquinoline derivatives (T37.8-)
From T37 Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics applies to 144 codes
  • anti-infectives topically used for ear, nose and throat (T49.6-)
  • anti-infectives topically used for eye (T49.5-)
  • locally applied anti-infectives NEC (T49.0-)
From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Code First

The underlying condition named in the note is sequenced before this code.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances applies to 3,186 codes
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

From T37 Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics applies to 144 codes
  • The appropriate 7th character is to be added to each code from category T37
  • Ainitial encounter this code
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T37.2X4A, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming T37.2X4A: they are not reported together with it, unless the two conditions are unrelated.

  • T37.8 Poisoning by, adverse effect of and underdosing of other specified systemic anti-infectives and antiparasitics
    antimalarial drugs (T37.2-) names T37.2-, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR EXT023
External cause codes: intent of injury, undetermined
Default principal diagnosis: inpatient No · outpatient No
CCSR EXT014
External cause codes: poisoning by drug
Default principal diagnosis: inpatient No · outpatient No
CCSR INJ022
Poisoning by drugs, initial encounter
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of Drugs and ChemicalsClinical

Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.

SubstanceAccidentalSelf-harmAssaultUndeter­minedAdverse
Effect
Under­dosing
8-Aminoquinoline drugsT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
AmodiaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Amopyroquin (e)T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Anti-infective NEC::antimalarialT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Anti-infective NEC::antiprotozoal NEC::bloodT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
AntimalarialT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Antimalarial::prophylactic NECT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Antimalarial::pyrimidine derivativeT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Antiprotozoal drug NEC::bloodT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
AralenT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
CamoquinT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ChloroguanideT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ChloroquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ChlorproguanilT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
CinchonaT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Cinchonine alkaloidsT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Cycloguanil embonateT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
DaraprimT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
EflornithineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
GuanatolT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
HalofantrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
IsopentaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
MefloquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
MepacrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PaludrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Pamaquine (naphthoute)T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PentaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PrimaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ProguanilT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PyrimethamineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Pyrimethamine::with sulfadoxineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
QuinacrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
QuinineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
QuinocideT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Schizontozide (blood) (tissue)T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Sulfadoxine::with pyrimethamineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6

Patient EducationClinical

Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert T37.2X4A to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
961.4 Poisoning-antimalarials
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
E980.4 Undet pois-med agnt NEC
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T37.2X4AOverview

Is T37.2X4A a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What does the 7th character A in T37.2X4A mean?

The final character A marks the initial encounter: use it while the patient is receiving active treatment for poisoning by antimalarials and drugs acting on other blood protozoa, undetermined, such as an emergency visit or first evaluation.

What MS-DRG does T37.2X4A group to?

When poisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 918, 917, with relative weights from 0.8716 to 1.5698 depending on complications. Higher weights mean higher Medicare reimbursement.

Can T37.2X4A be reported with a code from T37.8?

Not as a rule. The Excludes1 note at T37.2, which applies to T37.2X4A, lists "hydroxyquinoline derivatives (T37.8-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of T37.2X4A?

Under the General Equivalence Mappings, poisoning by antimalarials and drugs acting on other blood protozoa, undetermined, initial encounter converts to ICD-9-CM 961.4 (poisoning-antimalarials) and E980.4 (undet pois-med agnt NEC). The mapping is approximate, so confirm the match fits the documentation.