2026 ICD-10-CM Diagnosis Code Q99.89Other specified chromosome abnormalities

ICD-10-CM Codes›Q00-Q99›Q90-Q99›Q99

ICD-10-CM Q99.89
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Q99.89 is a billable ICD-10-CM diagnosis code for other specified chromosome abnormalities. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 729 through 730, 742 through 743, 760 through 761. The code is exempt from POA reporting.

Code Identity

ICD-10-CM Code
Q99.89
Billable Status
Yes — Valid for Submission
Code Describes
Other specified chromosome abnormalities
Short Description
Other specified chromosome abnormalities
Same as the full description in the CMS dataset.
Parent Code
Q99.8
Other specified chromosome abnormalities

Code Classification

ChapterQ00-Q99Congenital malformations, deformations and chromosomal abnormalities
SectionQ90-Q99Chromosomal abnormalities, not elsewhere classified
CategoryQ99Other chromosome abnormalities, not elsewhere classified
This CodeQ99.89Other specified chromosome abnormalities

Present on Admission (POA)Billing

Q99.89 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • 16p12.1p12.3 triplication syndrome
  • 49,XXXYY syndrome
  • Abnormal spermatogenesis
  • Acute myeloid leukemia with CEBPA somatic mutations
  • Acute myeloid leukemia with inv; RPN1-EVI1
  • Acute myeloid leukemia with myelodysplasia-related changes
  • Acute myeloid leukemia with NPM1 somatic mutation
  • Additional sex chromosome
  • Anomaly of chromosome pair
  • Anomaly of chromosome X
  • Anomaly of chromosome Y
  • Anomaly of sex chromosome
  • Ataxia-telangiectasia-like disorder
  • Atypical Norrie disease due to monosomy Xp11.3
  • Autosomal aneuploidy
  • Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation
  • Autosomal dominant congenital fiber-type disproportion myopathy due to ACTA1 mutation
  • Autosomal dominant congenital fiber-type disproportion myopathy due to TPM3 mutation
  • Autosomal dominant intellectual disability, craniofacial dysmorphism, macrocephaly, hypotonia syndrome due to H1-4 mutation
  • Autosomal recessive congenital fiber-type disproportion myopathy due to ACTA1 mutation
  • Autosomal recessive congenital fiber-type disproportion myopathy due to TPM3 mutation
  • Autosomal recessive hyper-IgE syndrome due to ZNF341 deficiency
  • Biallelic RPE65 mutation associated retinal dystrophy
  • Café au lait spots
  • Catecholaminergic polymorphic ventricular tachycardia
  • Catecholaminergic polymorphic ventricular tachycardia due to calsequestrin mutation
  • Centromeric instability of chromosomes 1,9 and 16 and immunodeficiency
  • Chimera
  • CHMP2B-related frontotemporal dementia
  • Chromosomal alterations of group A
  • Chromosomal alterations of group B
  • Chromosomal alterations of group C and X
  • Chromosomal alterations of group D
  • Chromosomal alterations of group E
  • Chromosomal alterations of group F
  • Chromosomal alterations of group G and Y
  • Chromosome 18 syndromes and antibody deficiency
  • Chromosome 22 abnormalities with hypogammaglobulinemia
  • Chromosome Xq27.3q28 duplication syndrome
  • Combined heterozygous low density lipoprotein receptor co-occurrent with low density lipoprotein receptor adaptor protein 1 mutations
  • Combined immunodeficiency due to OX40 deficiency
  • Congenital cleft larynx
  • Congenital fiber-type disproportion myopathy due to ACTA1 mutation
  • Congenital fiber-type disproportion myopathy due to MYH7 mutation
  • Congenital fiber-type disproportion myopathy due to TPM3 mutation
  • Congenital hypoplasia of adrenal gland
  • Congenital hypothyroidism due to dual oxidase maturation factor 2
  • Congenital hypothyroidism due to symporter mutation
  • Congenital hypothyroidism due to thyroglobulin mutation
  • Congenital hypothyroidism due to thyroid deiodinase mutation
  • Congenital hypothyroidism due to thyroid stimulating hormone receptor mutation
  • Congenital leptin deficiency
  • Cystic fibrosis due to heterozygous deltaF508 mutation
  • Cystic fibrosis due to homozygous deltaF508 mutation
  • Deficiency of DNA repair
  • Deficiency of glycerol kinase
  • Deletion of X-chromosome and hypogammaglobulinemia
  • Disorder of glycerol metabolism
  • DNA instability syndrome
  • DNA repair
  • Duplication of chromosome
  • Emanuel syndrome
  • Emberger syndrome
  • Epigenetic disorder
  • Extra unidentified structurally abnormal chromosome
  • Familial cardiomyopathy
  • Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
  • Familial hypercholesterolemia
  • Familial hypercholesterolemia - homozygous
  • Familial hypercholesterolemia due to heterozygous LDL receptor mutation
  • Familial hypercholesterolemia due to homozygous LDL receptor mutation
  • Finding of spermatozoa morphology
  • Genetic non-syndromic childhood obesity
  • Group chromosomal alteration
  • Gynandromorphism syndrome
  • Hereditary disorder of musculoskeletal system
  • Hereditary hemoglobinopathy due to globin chain mutation
  • Hereditary retinal dystrophy primarily involving retinal pigment epithelium
  • Heritable pulmonary arterial hypertension
  • Heritable pulmonary arterial hypertension due to ALK1 or endoglin mutation
  • Heterologous chimera
  • Homologous chimera
  • Hyperimmunoglobulin E syndrome
  • Hypertension due to gain-of-function mutation in mineralocorticoid receptor
  • Imprinting error
  • Interleukin-1 receptor-associated kinase 4 deficiency
  • Intrauterine growth restriction, congenital multiple café au lait macules, increased sister chromatid exchange syndrome
  • Isochromosomy Yp
  • Isochromosomy Yq
  • Isologous chimera
  • Lissencephaly due to TUBA1A mutation
  • Low density lipoprotein receptor adaptor protein 1 mutation
  • Low density lipoprotein receptor mutation
  • Lung disease, immunodeficiency, chromosome breakage syndrome
  • Male infertility of genetic origin
  • Male infertility with azoospermia due to single gene mutation
  • Male infertility with oligozoospermia due to single gene mutation
  • Male infertility with teratozoospermia due to single gene mutation
  • Maternal imprinting error
  • Maternal uniparental disomy of chromosome 1
  • Maternal uniparental disomy of chromosome 11
  • Maternal uniparental disomy of chromosome 13
  • Maternal uniparental disomy of chromosome 14
  • Maternal uniparental disomy of chromosome 15
  • Maternal uniparental disomy of chromosome 16
  • Maternal uniparental disomy of chromosome 2
  • Maternal uniparental disomy of chromosome 20
  • Maternal uniparental disomy of chromosome 21
  • Maternal uniparental disomy of chromosome 22
  • Maternal uniparental disomy of chromosome 4
  • Maternal uniparental disomy of chromosome 6
  • Maternal uniparental disomy of chromosome 7
  • Maternal uniparental disomy of chromosome 9
  • Maternal uniparental disomy of chromosome X
  • MECP2 related disorder
  • Megakaryoblastic acute myeloid leukemia with t
  • Mendelian disorders
  • Microduplication Xp11.22p11.23 syndrome
  • Mosaic genome-wide paternal uniparental disomy
  • Mosaic variegated aneuploidy syndrome
  • Multiple malformation syndrome, moderate short stature, facial
  • Oligozoospermia
  • Opitz-Frias syndrome
  • Partial chromosome Y deletion
  • Partial tetrasomy of chromosome 9
  • Paternal imprinting error
  • Paternal uniparental disomy of chromosome 1
  • Paternal uniparental disomy of chromosome 11
  • Paternal uniparental disomy of chromosome 13
  • Paternal uniparental disomy of chromosome 14
  • Paternal uniparental disomy of chromosome 15
  • Paternal uniparental disomy of chromosome 20
  • Paternal uniparental disomy of chromosome 21
  • Paternal uniparental disomy of chromosome 4
  • Paternal uniparental disomy of chromosome 5
  • Paternal uniparental disomy of chromosome 6
  • Paternal uniparental disomy of chromosome 7
  • Paternal uniparental disomy of chromosome X
  • Pelizaeus Merzbacher like disease
  • Pelizaeus Merzbacher like disease due to AIMP1 mutation
  • Pelizaeus Merzbacher like disease due to GJC2 mutation
  • Pelizaeus Merzbacher like disease due to HSPD1 mutation
  • Pelizaeus Merzbacher like disease due to SLC16A2 mutation
  • Penile hypospadias
  • Poly Y syndrome
  • Polygenic hereditary disorder
  • Polymicrogyria due to TUBB2B mutation
  • Recombinant chromosome 8 syndrome
  • Retinal pigment epithelial dystrophy
  • Sex chromosome aneuploidy
  • Sex chromosome mosaicism
  • Sex-linked hereditary disorder
  • Susceptibility to respiratory infection associated with CD8alpha chain mutation
  • Symptomatic form of Coffin-Lowry syndrome in female carrier
  • Syndromic X-linked intellectual disability due to JARID1C mutation
  • Teratozoospermia
  • Tetrasomy 11q24.1
  • Tetrasomy 12p syndrome
  • Tetrasomy 15q
  • Tetrasomy 18p
  • Tetrasomy 21
  • Tetrasomy 5p mosaicism
  • Tetrasomy 5p syndrome
  • Tetrasomy of short arm of chromosome 9
  • Trinucleotide repeat disorder
  • Unbalanced translocation and insertion
  • Unbalanced translocation of chromosome
  • Uniparental disomy
  • Uniparental disomy of maternal origin
  • Uniparental disomy of paternal origin
  • Ventricular tachycardia, polymorphic
  • X small rings
  • X-linked hereditary disease
  • Xp21 deletion syndrome
  • Xp22.13p22.2 duplication syndrome
  • Xq12-q13.3 duplication syndrome
  • Xq25 microduplication syndrome

Clinical InformationClinical

  • Chimera

    an individual that contains cell populations derived from different zygotes.

  • Proteolysis Targeting Chimera

    bifunctional molecules that are designed to recruit e3 ubiquitin ligase to a specific target protein. proteolysis targeting chimera consist of a target protein ligand connected via a linker to an e3 ligand. they promote association of e3 with specific target proteins tagged for degradation via the proteasome.

  • Radiation Chimera

    an organism whose body contains cell populations of different genotypes as a result of the transplantation of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.

  • Transplantation Chimera

    an organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. this state may result in the induction of donor-specific transplantation tolerance.

  • Asthenozoospermia

    a condition in which the percentage of motile sperm is abnormally low.

  • Teratozoospermia

    conditions in which sperm show abnormal morphology.

  • DNA End-Joining Repair

    the repair of double-strand dna breaks by rejoining the broken ends of dna to each other directly.

  • DNA Repair

    the removal of dna lesions and/or restoration of intact dna strands without base pair mismatches, intrastrand or interstrand crosslinks, or discontinuities in the dna sugar-phosphate backbones.

  • DNA Repair Enzymes

    enzymes that are involved in the reconstruction of a continuous two-stranded dna molecule without mismatch from a molecule, which contained damaged regions.

  • DNA Repair-Deficiency Disorders

    disorders resulting from defective dna repair processes or the associated cellular responses to dna damage.

  • O(6)-Methylguanine-DNA Methyltransferase

    an enzyme that transfers methyl groups from o(6)-methylguanine, and other methylated moieties of dna, to a cysteine residue in itself, thus repairing alkylated dna in a single-step reaction. ec 2.1.1.63.

  • Rad52 DNA Repair and Recombination Protein

    a dna-binding protein that mediates dna repair of double strand breaks, and homologous recombination.

  • Recombinational DNA Repair

    repair of dna damage by exchange of dna between matching sequences, usually between the allelic dna (alleles) of sister chromatids.

  • Uniparental Disomy

    the presence in a cell of two paired chromosomes from the same parent, with no chromosome of that pair from the other parent. this chromosome composition stems from non-disjunction (nondisjunction, genetic) events during meiosis. the disomy may be composed of both homologous chromosomes from one parent (heterodisomy) or a duplicate of one chromosome (isodisomy).

  • Transplantation

    transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.

  • Transplantation Tolerance

    an induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.

  • DNA

    a deoxyribonucleotide polymer that is the primary genetic material of all cells. eukaryotic and prokaryotic organisms normally contain dna in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. dna, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

  • Xq25 Microduplication Syndrome

    an x-linked genetic condition caused by duplication of a small segment of xq25, which may encompass the gria3 and stag2 genes, encoding glutamate receptor 3 and cohesin subunit sa-2. it is characterized by intellectual disability and distinctive facial dysmorphisms.

  • Maternal Uniparental Disomy Chromosome 14 Syndrome|Temple Syndrome|Temple Syndrome|mUPD14 Syndrome|mUPD14 Syndrome

    a cause of obesity that results from inheritance of two copies of chromosome 14 from the mother, and no copy of chromosome 14 from the father.

  • Uniparental Disomy

    a condition characterized by the inheritance of a chromosome pair from one parent and no chromosomal copies from the other parent. it results in developmental abnormalities or rare recessive disorders. examples of uniparental disomy include the prader-willi syndrome and angelman syndrome.

Code History & ChangesHistory

New Code Q99.89 was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.

Replacement Q99.89 replaces the following previously assigned code(s):

  • Q99.8 - Other specified chromosome abnormalities
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2026CurrentRevised in the current code setEffective October 1, 2025 through September 30, 2026.

Questions About Q99.89Overview

Is Q99.89 (Other specified chromosome abnormalities) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified chromosome abnormalities on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does Q99.89 group to?

When other specified chromosome abnormalities is the principal diagnosis on an inpatient stay, it groups to MS-DRG 729, 730, 742, 743, 760, 761, with relative weights from 0.5696 to 1.8348 depending on complications. Higher weights mean higher Medicare reimbursement.

Is Q99.89 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for other specified chromosome abnormalities on inpatient claims.