2027 ICD-10-CM Diagnosis Code Q99.89Other specified chromosome abnormalities

ICD-10-CM Codes›Q00-Q99›Q90-Q99›Q99

ICD-10-CM Q99.89
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Q99.89 is a billable ICD-10-CM diagnosis code for other specified chromosome abnormalities. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 729 through 730, 742 through 743, 760 through 761. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Chromosomal abnormalities.

Code Identity

ICD-10-CM Code
Q99.89
Billable Status
Yes — Valid for Submission
Code Describes
Other specified chromosome abnormalities
Short Description
Other specified chromosome abnormalities
Same as the full description in the CMS dataset.
Parent Code
Q99.8
Other specified chromosome abnormalities

Code Classification

ChapterQ00-Q99Congenital malformations, deformations and chromosomal abnormalities
SectionQ90-Q99Chromosomal abnormalities, not elsewhere classified
CategoryQ99Other chromosome abnormalities, not elsewhere classified
This CodeQ99.89Other specified chromosome abnormalities

Present on Admission (POA)Billing

Q99.89 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Chromosomal abnormalities, not elsewhere classified (Q90-Q99).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • 16p12.1p12.3 triplication syndrome
  • 49,XXXYY syndrome
  • Abnormal spermatogenesis
  • Acute myeloid leukemia with CEBPA somatic mutations
  • Acute myeloid leukemia with inv; RPN1-EVI1
  • Acute myeloid leukemia with myelodysplasia-related changes
  • Acute myeloid leukemia with NPM1 somatic mutation
  • Additional sex chromosome
  • Anomaly of chromosome pair
  • Anomaly of chromosome X
  • Anomaly of chromosome Y
  • Anomaly of sex chromosome
  • Ataxia-telangiectasia-like disorder
  • Atypical Norrie disease due to monosomy Xp11.3
  • Autosomal aneuploidy
  • Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation
  • Autosomal dominant congenital fiber-type disproportion myopathy due to ACTA1 mutation
  • Autosomal dominant congenital fiber-type disproportion myopathy due to TPM3 mutation
  • Autosomal dominant intellectual disability, craniofacial dysmorphism, macrocephaly, hypotonia syndrome due to H1-4 mutation
  • Autosomal dominant predisposition to severe viral infection due to TLR3 deficiency
  • Autosomal dominant severe congenital neutropenia
  • Autosomal dominant severe congenital neutropenia due to GFI1 mutation
  • Autosomal dominant thrombocytopenia due to ETV6 gene mutation
  • Autosomal recessive congenital fiber-type disproportion myopathy due to ACTA1 mutation
  • Autosomal recessive congenital fiber-type disproportion myopathy due to TPM3 mutation
  • Autosomal recessive hyper-IgE syndrome due to ZNF341 deficiency
  • Biallelic RPE65 mutation associated retinal dystrophy
  • Café au lait spots
  • Calcium release deficiency syndrome
  • Catecholaminergic polymorphic ventricular tachycardia
  • Catecholaminergic polymorphic ventricular tachycardia due to calsequestrin mutation
  • Centromeric instability of chromosomes 1,9 and 16 and immunodeficiency
  • Chimera
  • CHMP2B-related frontotemporal dementia
  • Chromosomal alterations of group A
  • Chromosomal alterations of group B
  • Chromosomal alterations of group C and X
  • Chromosomal alterations of group D
  • Chromosomal alterations of group E
  • Chromosomal alterations of group F
  • Chromosomal alterations of group G and Y
  • Chromosome 18 syndromes and antibody deficiency
  • Chromosome 22 abnormalities with hypogammaglobulinemia
  • Chromosome Xq27.3q28 duplication syndrome
  • Combined heterozygous low density lipoprotein receptor co-occurrent with low density lipoprotein receptor adaptor protein 1 mutations
  • Combined immunodeficiency due to OX40 deficiency
  • Combined immunodeficiency due to TBX1 mutation
  • Congenital cleft larynx
  • Congenital fiber-type disproportion myopathy due to ACTA1 mutation
  • Congenital fiber-type disproportion myopathy due to MYH7 mutation
  • Congenital fiber-type disproportion myopathy due to TPM3 mutation
  • Congenital hypoplasia of adrenal gland
  • Congenital hypothyroidism due to dual oxidase maturation factor 2
  • Congenital hypothyroidism due to symporter mutation
  • Congenital hypothyroidism due to thyroglobulin mutation
  • Congenital hypothyroidism due to thyroid deiodinase mutation
  • Congenital hypothyroidism due to thyroid stimulating hormone receptor mutation
  • Congenital leptin deficiency
  • Congenital neutropenia, combined immunodeficiency due to MKL1 deficiency
  • Cystic fibrosis due to heterozygous deltaF508 mutation
  • Cystic fibrosis due to homozygous deltaF508 mutation
  • Deficiency of DNA repair
  • Deficiency of glycerol kinase
  • Deletion of X-chromosome and hypogammaglobulinemia
  • Disorder of glycerol metabolism
  • DNA instability syndrome
  • DNA repair
  • Duplication of chromosome
  • Early-onset autoinflammatory syndrome due to A20 haploinsufficiency
  • Emanuel syndrome
  • Emberger syndrome
  • Epigenetic disorder
  • Extra unidentified structurally abnormal chromosome
  • Familial cardiomyopathy
  • Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
  • Familial hypercholesterolemia
  • Familial hypercholesterolemia - homozygous
  • Familial hypercholesterolemia due to heterozygous LDL receptor mutation
  • Familial hypercholesterolemia due to homozygous LDL receptor mutation
  • Finding of spermatozoa morphology
  • Genetic non-syndromic childhood obesity
  • Greig cephalopolysyndactyly, contiguous gene syndrome
  • Group chromosomal alteration
  • Gynandromorphism syndrome
  • Haploinsufficiency of A20
  • Hereditary disorder of musculoskeletal system
  • Hereditary hemoglobinopathy due to globin chain mutation
  • Hereditary retinal dystrophy primarily involving retinal pigment epithelium
  • Heritable pulmonary arterial hypertension
  • Heritable pulmonary arterial hypertension due to ALK1 or endoglin mutation
  • Heterologous chimera
  • Homologous chimera
  • Hyperimmunoglobulin E syndrome
  • Hypertension due to gain-of-function mutation in mineralocorticoid receptor
  • Imprinting error
  • Interleukin-1 receptor-associated kinase 4 deficiency
  • Intrauterine growth restriction, congenital multiple café au lait macules, increased sister chromatid exchange syndrome
  • Isochromosomy Yp
  • Isochromosomy Yq
  • Isologous chimera
  • Lissencephaly due to TUBA1A mutation
  • Low density lipoprotein receptor adaptor protein 1 mutation
  • Low density lipoprotein receptor mutation
  • Lung disease, immunodeficiency, chromosome breakage syndrome
  • Male infertility of genetic origin
  • Male infertility with azoospermia due to single gene mutation
  • Male infertility with oligozoospermia due to single gene mutation
  • Male infertility with teratozoospermia due to single gene mutation
  • Mandibuloacral dysplasia associated to MTX2
  • Maternal imprinting error
  • Maternal uniparental disomy of chromosome 1
  • Maternal uniparental disomy of chromosome 11
  • Maternal uniparental disomy of chromosome 13
  • Maternal uniparental disomy of chromosome 14
  • Maternal uniparental disomy of chromosome 15
  • Maternal uniparental disomy of chromosome 16
  • Maternal uniparental disomy of chromosome 2
  • Maternal uniparental disomy of chromosome 20
  • Maternal uniparental disomy of chromosome 21
  • Maternal uniparental disomy of chromosome 22
  • Maternal uniparental disomy of chromosome 4
  • Maternal uniparental disomy of chromosome 6
  • Maternal uniparental disomy of chromosome 7
  • Maternal uniparental disomy of chromosome 9
  • Maternal uniparental disomy of chromosome X
  • MECP2 related disorder
  • Megakaryoblastic acute myeloid leukemia with t
  • Mendelian disorders
  • Microduplication Xp11.22p11.23 syndrome
  • Mosaic genome-wide paternal uniparental disomy
  • Mosaic variegated aneuploidy syndrome
  • Multiple malformation syndrome, moderate short stature, facial
  • Oligozoospermia
  • Opitz-Frias syndrome
  • Partial chromosome Y deletion
  • Partial tetrasomy of chromosome 9
  • Paternal imprinting error
  • Paternal uniparental disomy of chromosome 1
  • Paternal uniparental disomy of chromosome 11
  • Paternal uniparental disomy of chromosome 13
  • Paternal uniparental disomy of chromosome 14
  • Paternal uniparental disomy of chromosome 15
  • Paternal uniparental disomy of chromosome 20
  • Paternal uniparental disomy of chromosome 21
  • Paternal uniparental disomy of chromosome 4
  • Paternal uniparental disomy of chromosome 5
  • Paternal uniparental disomy of chromosome 6
  • Paternal uniparental disomy of chromosome 7
  • Paternal uniparental disomy of chromosome X
  • Pelizaeus Merzbacher like disease
  • Pelizaeus Merzbacher like disease due to AIMP1 mutation
  • Pelizaeus Merzbacher like disease due to GJC2 mutation
  • Pelizaeus Merzbacher like disease due to HSPD1 mutation
  • Pelizaeus Merzbacher like disease due to SLC16A2 mutation
  • Penile hypospadias
  • Poly Y syndrome
  • Polygenic hereditary disorder
  • Polymicrogyria due to TUBB2B mutation
  • Recombinant chromosome 8 syndrome
  • Retinal pigment epithelial dystrophy
  • Sex chromosome aneuploidy
  • Sex chromosome mosaicism
  • Sex-linked hereditary disorder
  • Susceptibility to respiratory infection associated with CD8alpha chain mutation
  • Symptomatic form of Coffin-Lowry syndrome in female carrier
  • Syndromic X-linked intellectual disability due to JARID1C mutation
  • Teratozoospermia
  • Tetrasomy 11q24.1
  • Tetrasomy 12p syndrome
  • Tetrasomy 15q
  • Tetrasomy 18p
  • Tetrasomy 21
  • Tetrasomy 5p mosaicism
  • Tetrasomy 5p syndrome
  • Tetrasomy of short arm of chromosome 9
  • Trinucleotide repeat disorder
  • Unbalanced translocation and insertion
  • Unbalanced translocation of chromosome
  • Uniparental disomy
  • Uniparental disomy of maternal origin
  • Uniparental disomy of paternal origin
  • Ventricular tachycardia, polymorphic
  • X small rings
  • X-linked hereditary disease
  • Xp21 deletion syndrome
  • Xp22.13p22.2 duplication syndrome
  • Xq12-q13.3 duplication syndrome
  • Xq25 microduplication syndrome

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Q99.89: its own notes plus those printed at block Q90-Q99 and Chapter 17. A note printed at a category, block or chapter applies to every code under it.

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block Q90-Q99 Chromosomal abnormalities, not elsewhere classified applies to 74 codes
  • mitochondrial metabolic disorders (E88.4-)
From Chapter 17 (Q00-QA1) Congenital malformations, deformations and chromosomal abnormalities applies to 900 codes
  • inborn errors of metabolism (E70-E88)

Notes

General instructions on how these codes are used.

From Chapter 17 (Q00-QA1) Congenital malformations, deformations and chromosomal abnormalities applies to 900 codes
  • Codes from this chapter are not for use on maternal records

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Q99.89, its category, or a range that includes it.

Excludes1 4

These codes carry an Excludes1 note naming Q99.89: they are not reported together with it, unless the two conditions are unrelated.

  • E25 Adrenogenital disorders
    chromosomal abnormalities (Q90-Q99) names Q90-Q99, which includes this code
  • Block Q50-Q56 Congenital malformations of genital organs
    syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99) names Q90-Q99, which includes this code
  • Q56 Indeterminate sex and pseudohermaphroditism
    pseudohermaphroditism with specified chromosomal anomaly (Q96-Q99) names Q96-Q99, which includes this code
  • Z15 Genetic susceptibility to disease
    chromosomal anomalies (Q90-Q99) names Q90-Q99, which includes this code

Code First 1

These codes say to code first a condition named in the note, and Q99.89 is one of the conditions named.

  • D84.81 Immunodeficiency due to conditions classified elsewhere
    chromosomal abnormalities (Q90-Q99) names Q90-Q99, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MAL009
Chromosomal abnormalities
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement Q99.89 replaces the following previously assigned code(s):

  • Q99.8 - Other specified chromosome abnormalities
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Q99.89Overview

What is the ICD-10 code for other specified chromosome abnormalities?

The ICD-10-CM code for other specified chromosome abnormalities is Q99.89 (sometimes written as Q9989). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is Q99.89 (Other specified chromosome abnormalities) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified chromosome abnormalities on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Q99.89 group to?

When other specified chromosome abnormalities is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 729, 743, 760, 761, 730, with relative weights from 0.6595 to 1.8448 depending on complications. Higher weights mean higher Medicare reimbursement.

Is Q99.89 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for other specified chromosome abnormalities on inpatient claims. The code appears in the Chromosomal abnormalities, not elsewhere classified (Q90-Q99) range of the CMS exempt list.